Advances in Carnitine in Chronic Uremia

Journal of Renal Nutrition

Volumn 17, Issue 1, 2007, Pages 23-29

  Guarnieri, Gianfranco ^a   Biolo, Gianni ^a   Vinci, Pierandrea ^a   Massolino, Benedetta ^a   Barazzoni, Rocco ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE; VITAMIN B COMPLEX;

ARTICLE; CHRONIC DISEASE; CHRONIC KIDNEY FAILURE; ENERGY METABOLISM; HOMEOSTASIS; HUMAN; METABOLISM; PHYSIOLOGY; RENAL REPLACEMENT THERAPY; UREMIA;

CARNITINE; CHRONIC DISEASE; ENERGY METABOLISM; HOMEOSTASIS; HUMANS; KIDNEY FAILURE, CHRONIC; RENAL DIALYSIS; UREMIA; VITAMIN B COMPLEX;

EID: 33845765725     PISSN: 10512276     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jrn.2006.10.006     Document Type: Article

References (56)

1. DiLisa F., Barbato R., Menabò R., et al. Carnitine and carnitine esters in mitochondial metabolism and function. In: DeJong J., and Ferrari R. (Eds). The Carnitine System (2005), Kluwer Academic Publishers, Norwell, Massachusetts 21-38
2. Guarnieri G., Situlin R., and Biolo G. Carnitine metabolism in uremia. Am J Kidney Dis 38 (2001) S63-S67
3. Guarnieri G., Biolo G., Toigo G., et al. Carnitine in renal failure. In: Kopple J., and Massry S. (Eds). Nutritional Management of Renal Disease (2001), Lippincott Williams & Wilkins, Baltimore, Maryland 357-368
4. Ramsay R.R., and Zammit V.A. Carnitine acyltransferases and their influence on CoA pools in health and disease. Mol Aspects Med 25 (2004) 475-493
5. Foster D.W. The role of the carnitine system in human metabolism. Ann N Y Acad Sci 1033 (2004) 1-16
6. Steiber A., Kerner J., and Hoppel C.L. Carnitine: A nutritional, biosynthetic, and functional perspective. Mol Aspects Med 25 (2004) 455-473
7. Schreiber B. Levocarnitine and dialysis: A review. Nutr Clin Practice 20 (2005) 218-243
8. Lohninger A., Pittner G., and Pittner F. L-carnitine: New aspects of a known compound-A brief survey. Monatshefte Chemie 136 (2005) 1255-1368
9. Zammit V.A., Price N.T., Jackson V.N., et al. The role of carnitine acyltransferases in the maintenance of cell function. Monatshefte Chemie 136 (2005) 1299-1309
10. Guarnieri G., Toigo G., Crapesi L., et al. Carnitine metabolism in chronic renal failure. Kidney Int 32 (1987) S116-S127
11. Guarnieri G., Toigo G., Crapesi L., et al. Metabolic effects of supplementation of L-carnitine in the dialysate of patients treated with acetate hemodialysis. Kidney Int 36 (1989) S247-S255
12. Golper T.A., and Ahmad S. L-carnitine administration to hemodialysis patients: Has its time come?. Semin Dial 5 (1992) 94-98
13. Evans A.M., Faull R., Fornasini G., et al. Pharmacokinetics of L-carnitine in patients with end-stage renal disease undergoing long-term hemodialysis. Clin Pharmacol Ther 68 (2000) 238-249
14. Evans A.M., Faull R.J., Nation R.L., et al. Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease. Kidney Int 66 (2004) 1527-1534
15. Reuter S.E., Evans A.M., Faull R.J., et al. Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal disease. Ann Clin Biochem 42 (2005) 387-393
16. Calvani M., Benatti P., Mancinelli A., et al. Carnitine replacement in end-stage renal disease and hemodialysis. Ann N Y Acad Sci 1033 (2004) 52-66
17. Hurot J.M., Cucherat M., Haugh M., et al. Effects of L-carnitine supplementation in maintenance hemodialysis patients: A systematic review. J Am Soc Nephrol 13 (2002) 708-714
18. Golper T.A., Goral S., Becker B.N., et al. L-carnitine treatment of anemia. Am J Kidney Dis 41 (2003) S27-S34
19. Brass E.P., Adler S., Sietsema K.E., et al. Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients. Am J Kidney Dis 37 (2001) 1018-1028
20. Ahmad S., Robertson H.T., Golper T.A., et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kideny Int 38 (1990) 912-918
21. Ferrannini E., Buzzigoli G., Bevilacqua S., et al. Interaction of carnitine with insulin-stimulated glucose metabolism in humans. Am J Physiol 255 (1988) E946-E952
22. Gunal A.I., Celiker H., Donder E., et al. The effect of L-carnitine on insulin resistance in hemodialysed patients with chronic renal failure. J Nephrol 12 (1999) 38-40
23. Kelley D.E., He J., Menshikova E.V., et al. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51 (2002) 2944-2950
24. Adey D., Kumar R., McCarthy J.T., et al. Reduced synthesis of muscle proteins in chronic renal failure. Am J Physiol Endocrinol Metab 278 (2000) E219-E225
25. Smogorzewski M., Piskorska G., Borum P.R., et al. Chronic renal failure, parathyroid hormone and fatty acids oxidation in skeletal muscle. Kidney Int 33 (1988) 555-560
26. Pertosa G., Grandaliano G., Simone S., et al. Inflammation and carnitine in hemodialysis patients. J Ren Nutr 15 (2005) 8-12
27. Savica V., Santoro D., Mazzaglia G., et al. L-carnitine infusions may suppress serum C-reactive protein and improve nutritional status in maintenance hemodialysis patients. J Ren Nutr 15 (2005) 225-230
28. Famularo G., DeSimone C., Trinchieri V., et al. Carnitines and its congeners: A metabolic pathway to the regulation of immune response and inflammation. Ann N Y Acad Sci 1033 (2004) 132-138
29. DeSimone C., Tzantzoglu S., Famularo G., et al. High dose L-carnitine improves immunologic and metabolic parameters in AIDS patients. Immunopharmacol Immunotoxicol 15 (1993) 1-12
30. Saghizadeh M., Ong J.M., Garvey W.T., et al. The expression of TNF alpha by human muscle: Relationship to insulin resistance. J Clin Invest 97 (1996) 1111-1116
31. Eaton S., and Pierro A. Carnitine and fatty acid oxidation in sepsis. Monats Chemie 136 (2005) 1483-1492
32. Alesci S., DeMartino M.U., Mirani M., et al. L-carnitine: A nutritional modulator of glucocorticoid receptor functions. FASEB J 17 (2003) 1553-1555
33. Manoli I., De Martino M.U., Kino T., et al. Modulatory effects of L-carnitine on glucocorticoid receptor activity. Ann N Y Acad Sci 1033 (2004) 147-157
34. Winter B.K., Fiskum G., Gallo L.L., et al. Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock. Br J Cancer 72 (1995) 1173-1179
35. Vesela E., Racek J., Trefil L., et al. Effect of L-carnitine supplementation in hemodialysis patients. Nephron 88 (2001) 218-223
36. Evans J.L., Goldfine I.D., Maddux B.A., et al. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?. Diabetes 52 (2003) 1-8
37. Pignatelli P., Lenti L., Sanguigni V., et al. Carnitine inhibits arachidonic acid turnover, platelet function, and oxidative stress. Am J Physiol Heart Circ Physiol 284 (2003) H41-H48
38. Sener G., Paskaloglu K., Satiroglu H., et al. L-carnitine ameliorates oxidative damage due to chronic renal failure in rats. J Cardiovasc Pharmacol 43 (2004) 698-705
39. Calò L.A., Pagnin E., Davis P.A., et al. Antioxidant effect of L-carnitine and its short chain esters: Relevance for the protection from oxidative stress related cardiovascular damage. Int J Cardiol 107 (2006) 54-60
40. Trovato G.M., Iannetti E., Murgo A.M., et al. Body composition and long-term levo-carnitine supplementation. Clin Ter 149 (1998) 209-214
41. Owen K.Q., Jit H., Maxwell C.V., et al. Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine. J Anim Sci 79 (2001) 3104-3112
42. Ji H., Bradley T.M., and Tremblay G.C. Atlantic salmon (Salmo salar) fed L-carnitine exhibit altered intermediary metabolism and reduced tissue lipid, but no change in growth rate. J Nutr 126 (1996) 1937-1950
43. Mantovani G., Madeddu C., Maccio A., et al. Cancer-related anorexia-cachexia syndrome and oxidative stress: An innovative approach beyond current treatment. Cancer Epidemiol Biomarkers Prev 13 (2004) 1651-1659
44. Giovenali P., Fenocchio D., Montanari G., et al. Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers. Kidney Int 46 (1994) 1616-1619
45. Ahmad S., Robertson H.T., Golper T.A., et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 38 (1990) 912-918
46. Heller W., Musil H.E., Gaebel G., et al. Effect of L-carnitine on post-stress metabolism in surgical patients. Infusionsther Klin Ernahr 13 (1986) 268-276
47. Pichard C., Roulet M., Schutz Y., et al. Clinical relevance of L-carnitine-supplemented total parenteral nutrition in postoperative trauma: Metabolic effects of continuous or acute carnitine administration with special reference to fat oxidation and nitrogen utilization. Am J Clin Nutr 49 (1989) 283-289
48. Wutzke K.D., and Lorenz H. The effect of L-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects. Metabolism 53 (2004) 1002-1006
49. Biolo G., Stulle M., Piccoli A., et al. Carnitine depletion impairs the protein anabolic response to insulin in hemodialysis patients (2006) 41 Merida, Mexico, XIII International Congress on Nutrition and Metabolism in Renal Disease
50. Pons R., and DeVivo D.C. Primary and secondary carnitine deficiency syndromes. J Child Neurol 10 suppl 2 (1995) S8-S24
51. Kazmi W.H., Obrador G.T., Sternberg M., et al. Carnitine therapy is associated with decreased hospital utilization among hemodialysis patients. Am J Nephrol 25 (2005) 106-115
52. Steiber A.L., Davis A.T., Spry L., et al. Carnitine treatment improved quality-of-life measure in a sample of midwestern hemodialysis patients. JPEN J Parenter Enteral Nutr 30 (2006) 10-15
53. Steiber A.L., Weatherspoon L.J., Spry L., et al. Serum carnitine concentrations correlated to clinical outcome parameters in chronic hemodialysis patients. Clin Nutr 23 (2004) 27-34
54. Vaux E.C., Taylor D.J., Altmann P., et al. Effects of carnitine supplementation on muscle metabolism by the use of magnetic resonance spectroscopy and near-infrared spectroscopy in end-stage renal disease. Nephron Clin Pract 97 (2004) c41-c48
55. Chazot C., Blanc C., Hurot J.M., et al. Nutritional effects of carnitine supplementation in hemodialysis patients. Clin Nephrol 59 (2003) 24-30
56. Schreiber B. Common misconceptions about levocarnitine and dialysis. Semin Dial 18 (2005) 349-351