The effect of L-Carnitine on insulin resistance in hemodialysed patients with chronic renal failure

Journal of Nephrology

Volumn 12, Issue 1, 1999, Pages 38-40

  Günal, Ali Ihsan ^a,b   Celiker, Hüseyin ^a   Dönder, Emir ^a   Günal, Servin Yeşil ^a  

^a FIRAT UNIVERSITY   (Turkey)

^b EGE UNIVERSITY   (Turkey)

Author keywords

Chronic renal failure; Insulin resistance; L carnitine

Indexed keywords

CARNITINE; PLACEBO;

ADULT; ARTICLE; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HEMODIALYSIS; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTRAVENOUS DRUG ADMINISTRATION; MALE; UREMIA;

ADULT; CARNITINE; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; INSULIN RESISTANCE; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; RENAL DIALYSIS;

EID: 2442766181     PISSN: 11218428     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Mak RHK. Carbohydrate metabolism in uremia. Pediatr Nephrol 1989; 3: 201-8.
2. DeFronzo RA, Tobin JD, Rowe JW, Andres R. Glucose intolerance in uremia: quantification of pancreatic beta cell to glucose and tissue sensitivity to insulin. J Clin Invest 1978; 62: 425-35.
3. Goldberg AP, Hagberg JM, Delmez JA, Haynes ME, Harter HR. Metabolic effects of training in hemodialysis patients. Kidney Int 1980; 18: 754-61.
4. Allegra V, Mengozzi G, Martimbianco L, Vasile A. Glucose-induced insulin secretion in uremia: relation with acid-base balance and effects of bicarbonate administration. Nephron 1993; 63: 43-8.
5. Mak RHK: Intravenous 1,25 dihydroxycholecalciferol corrects glucose intolerance in hemodialysis patients. Kidney Int 1992; 41: 1049-54.
6. Mak RHK. Amelioration of hypertension and insulin resistance by 1,25 dihydroxycholecalciferol in hemodialysis patients. Pediatr Nephrol 1992; 6: 345-8.
7. Gunal AI, C, eliker H, Celebi H, Ustundag B, Gunal SY. Intravenous alfacalcidol improves insulin resistance in hemodialysis patients. Clin Nephrol 1997; 48: 109-13.
8. Mak RHK. Reversal of glucose intolerance and insulin resistance following correction of anemia by human recombinant erythropoietin in hemodialysis patients. Pediatr Res 1992; 31: 337A.
9. Hager SR. Insulin resistance of uremia. Am J Kidney Dis 1989; 14: 272-6.
10. Folli F, Sinha MK, Brancaccio D, et al. Insulin resistance in uremia: In vitro model in the rat liver using human serum to study mechanism. Metabolism 1986; 35: 989-98.
11. Karpati G, Carpenter S, Engel AG, et al. The syndrome of systemic carnitine deficiency. Neurology 1975; 25: 16-24.
12. Golper TA, Wolfson M, Ahmad S, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients. I. Carnitine concentrations and lipid effects. Kidney Int 1990; 38: 904-11.
13. Rodriguez-Segade S, Alonso de la Pena C, Paz JM, Novoa D, Arcocha V, Romero R, Del Rio R. Carnitine deficiency in hemodialysed patients. Clin Chim Acta 1986; 159: 249-56.
14. Bonoro E, Moghetti P, Zancanaro C, Cigolini M, Querene M, Cacciatiori V. Estimates of in vivo insulin action in man: Comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab 1989; 68: 374-8.
15. Gelding SV, Robinson S, Lowe S, Niththyananthan R, Jonston DG. Validation of the low dose short insulin tolerance test for evaluation of insulin sensitivity. Clin Endocrinol 1994; 40: 611-5.
16. Ferrari R, Diamuro S, Sherwood G. L-carnitine and its role in medicine: From function to therapy. London, Academic Press, 1992.
17. Borum PR, Taggard EM. Carnitine nutriture of dialysis patients. J Am Diet Assoc 1986; 86 (5): 644-7.
18. Susuki Y, Narita M, Yamazaki N: Effects of L-carnitine on arrhythmias during hemodialysis. Jap Heart J 1982; 23: 349-59.
19. Bouffard Y, Tissot S, Delafosse B, et al. Metabolic effects of hemodialysis with and without glucose in the dialysate. Kidney Int 1993; 43: 1086-90.
20. Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 1996; 97 (12): 2859-65.
21. Boden G, Chen X, Rosner J, Barton M. Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 1995; 44(10): 1239-42.
22. Maeda K, Shinzato T, Kobayakawa H. Effects of L-carnitine administration on short chain fatty acids (acetic acid) and long-chain fatty acid metabolism during hemodialysis. Nephron 1989; 51 (3): 355-61.
23. Porte D. Beta-cells in Type II diabetes mellitus. Diabetes 1991; 40: 166-80.
24. Kautzky-Willer A, Pacini C, Barnas U, et al. Intravenous calcitriol normalizes insulin sensitivity in uremic patients. Kidney Int 1995; 47: 200-6.