Acyclic, orally bioavailable ketone-based cathepsin K inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 1, 2007, Pages 22-27

  Barrett, David G ^a   Catalano, John G ^a   Deaton, David N ^a   Long, Stacey T ^a   McFadyen, Robert B ^a   Miller, Aaron B ^a   Miller, Larry R ^a   Samano, Vicente ^a   Tavares, Francis X ^a   Wells Knecht, Kevin J ^a   Wright, Lois L ^a   Zhou, Hui Qiang Q ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Cathepsin K; Cysteine protease inhibitor; Electrophilic warhead; Osteoporosis

Indexed keywords

AMIDE; CATHEPSIN K INHIBITOR; KETONE;

ARTICLE; CHEMICAL MODIFICATION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HYBRIDIZATION; IC 50; INHIBITION KINETICS; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY ANALYSIS;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CATHEPSINS; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; HUMANS; KETONES; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845743014     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.102     Document Type: Article

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