Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)- en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-asparate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral α-amino acid bioisostere

Journal of Medicinal Chemistry

Volumn 41, Issue 2, 1998, Pages 236-246

  Kinney, William A ^a,b   Abou Gharbia, Magid ^a   Garrison, Deanna T ^a   Schmid, Jean ^a   Kowal, Dianne M ^a   Bramlett, Donna R ^a   Miller, Tracy L ^a   Tasse, Rene P ^a   Zaleska, Margaret M ^a   Moyer, John A ^a  

^a PFIZER INC   (United States)

^b Genaera Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; [2 (8,9 DIOXO 2,6 DIAZABICYCLO[5.2.0]NON 1(7) EN 2 YL)ETHYL]PHOSPHONIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG SYNTHESIS; HYDROGEN BOND; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN STRUCTURE; RECEPTOR BINDING; STROKE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CYCLOBUTANES; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY AMINO ACIDS; ISCHEMIC ATTACK, TRANSIENT; MICE; MODELS, CHEMICAL; N-METHYLASPARTATE; PIPECOLIC ACIDS; PIPERAZINES; RATS;

EID: 15144339410     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970504g     Document Type: Article

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