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Volumn 13, Issue 12, 2006, Pages 1633-1644

Immunohistochemical expression of p16INK4A, Ki-67, and Mcm2 proteins in gastrointestinal stromal tumors: Prognostic implications and correlations with risk stratification of NIH consensus criteria

Author keywords

GIST; Ki 67; Mcm2; NIH consensus criteria; p16INK4A

Indexed keywords

KI 67 ANTIGEN; MINICHROMOSOME MAINTENANCE PROTEIN 2; PROTEIN P16INK4A; CELL CYCLE PROTEIN; MCM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; TUMOR MARKER;

EID: 33845717325     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-006-9188-4     Document Type: Article
Times cited : (48)

References (49)
  • 1
    • 0036301722 scopus 로고    scopus 로고
    • Diagnosis of gastrointestinal stromal tumors: A consensus approach
    • Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 2002; 33(5):459-65.
    • (2002) Hum Pathol , vol.33 , Issue.5 , pp. 459-465
    • Fletcher, C.D.1    Berman, J.J.2    Corless, C.3
  • 2
    • 0036301863 scopus 로고    scopus 로고
    • Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: A review
    • Miettinen M, El-Rifai W, L HLS, Lasota J. Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol 2002; 33(5):478-83.
    • (2002) Hum Pathol , vol.33 , Issue.5 , pp. 478-483
    • Miettinen, M.1    El-Rifai, W.2    Lasota, J.3
  • 3
    • 4644312266 scopus 로고    scopus 로고
    • Biology of gastrointestinal stromal tumors
    • Corless CL, Fletcher JA, Heinrich MC. Biology of gastrointestinal stromal tumors. J Clin Oncol 2004; 22(18):3813-25.
    • (2004) J Clin Oncol , vol.22 , Issue.18 , pp. 3813-3825
    • Corless, C.L.1    Fletcher, J.A.2    Heinrich, M.C.3
  • 4
    • 23944476156 scopus 로고    scopus 로고
    • PDGFRA mutations in gastrointestinal stromal tumors: Frequency, spectrum and in vitro sensitivity to imatinib
    • Corless CL, Schroeder A, Griffith D, et al. PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol 2005; 23(23):5357-64.
    • (2005) J Clin Oncol , vol.23 , Issue.23 , pp. 5357-5364
    • Corless, C.L.1    Schroeder, A.2    Griffith, D.3
  • 5
    • 3442881363 scopus 로고    scopus 로고
    • Protein kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs)
    • Duensing A, Joseph NE, Medeiros F, et al. Protein kinase C theta (PKCtheta) expression and constitutive activation in gastrointestinal stromal tumors (GISTs). Cancer Res 2004; 64(15):5127-131.
    • (2004) Cancer Res , vol.64 , Issue.15 , pp. 5127-5131
    • Duensing, A.1    Joseph, N.E.2    Medeiros, F.3
  • 6
    • 3042538269 scopus 로고    scopus 로고
    • Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias
    • Blay P, Astudillo A, Buesa JM, et al. Protein kinase C theta is highly expressed in gastrointestinal stromal tumors but not in other mesenchymal neoplasias. Clin Cancer Res 2004; 10(12 Pt 1):4089-95.
    • (2004) Clin Cancer Res , vol.10 , Issue.12 PART 1 , pp. 4089-4095
    • Blay, P.1    Astudillo, A.2    Buesa, J.M.3
  • 7
    • 10744225271 scopus 로고    scopus 로고
    • Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors
    • Antonescu CR, Sommer G, Sarran L, et al. Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors. Clin Cancer Res 2003; 9(9):3329-37.
    • (2003) Clin Cancer Res , vol.9 , Issue.9 , pp. 3329-3337
    • Antonescu, C.R.1    Sommer, G.2    Sarran, L.3
  • 8
    • 0036303804 scopus 로고    scopus 로고
    • Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    • Heinrich MC, Rubin BP, Longley BJ, Fletcher JA. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol 2002; 33(5):484-95.
    • (2002) Hum Pathol , vol.33 , Issue.5 , pp. 484-495
    • Heinrich, M.C.1    Rubin, B.P.2    Longley, B.J.3    Fletcher, J.A.4
  • 9
    • 24944536236 scopus 로고    scopus 로고
    • Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: A study by the Spanish Group for Sarcoma Research (GEIS)
    • Martin J, Poveda A, Llombart-Bosch A, et al. Deletions affecting codons 557-558 of the c-KIT gene indicate a poor prognosis in patients with completely resected gastrointestinal stromal tumors: a study by the Spanish Group for Sarcoma Research (GEIS). J Clin Oncol 2005; 23(25):6190-8.
    • (2005) J Clin Oncol , vol.23 , Issue.25 , pp. 6190-6198
    • Martin, J.1    Poveda, A.2    Llombart-Bosch, A.3
  • 10
    • 9144241089 scopus 로고    scopus 로고
    • KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin
    • Lasota J, Kopczynski J, Sarlomo-Rikala M, et al. KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin. Hum Pathol 2003; 34(12):1306-12.
    • (2003) Hum Pathol , vol.34 , Issue.12 , pp. 1306-1312
    • Lasota, J.1    Kopczynski, J.2    Sarlomo-Rikala, M.3
  • 11
    • 11144284051 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors of the stomach: A clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up
    • Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am J Surg Pathol 2005; 29(1):52-68.
    • (2005) Am J Surg Pathol , vol.29 , Issue.1 , pp. 52-68
    • Miettinen, M.1    Sobin, L.H.2    Lasota, J.3
  • 12
    • 0028795581 scopus 로고
    • Differentiation and risk assessment of gastrointestinal stromal tumors
    • Franquemont DW. Differentiation and risk assessment of gastrointestinal stromal tumors. Am J Clin Pathol 1995; 103(1):41-7.
    • (1995) Am J Clin Pathol , vol.103 , Issue.1 , pp. 41-47
    • Franquemont, D.W.1
  • 13
    • 10744227336 scopus 로고    scopus 로고
    • Soft tissue sarcomas of adults: State of the translational science
    • Borden EC, Baker LH, Bell RS, et al. Soft tissue sarcomas of adults: state of the translational science. Clin Cancer Res 2003; 9(6):1941-56.
    • (2003) Clin Cancer Res , vol.9 , Issue.6 , pp. 1941-1956
    • Borden, E.C.1    Baker, L.H.2    Bell, R.S.3
  • 14
    • 0032517341 scopus 로고    scopus 로고
    • The p16INK4a/CDKN2A tumor suppressor and its relatives
    • Ruas M, Peters G. The p16INK4a/CDKN2A tumor suppressor and its relatives. Biochim Biophys Acta 1998; 1378(2):F115-77.
    • (1998) Biochim Biophys Acta , vol.1378 , Issue.2
    • Ruas, M.1    Peters, G.2
  • 15
    • 20044367805 scopus 로고    scopus 로고
    • Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: A highly lethal subset associated with poor chemoresponse
    • Huang HY, Illei PB, Zhao Z, et al. Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse. J Clin Oncol 2005; 23(3):548-58.
    • (2005) J Clin Oncol , vol.23 , Issue.3 , pp. 548-558
    • Huang, H.Y.1    Illei, P.B.2    Zhao, Z.3
  • 16
    • 0034660868 scopus 로고    scopus 로고
    • DNA sequence copy number changes in gastrointestinal stromal tumors: Tumor progression and prognostic significance
    • El-Rifai W, Sarlomo-Rikala M, Andersson LC, Knuutila S, Miettinen M. DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance. Cancer Res 2000; 60(14):3899-903.
    • (2000) Cancer Res , vol.60 , Issue.14 , pp. 3899-3903
    • El-Rifai, W.1    Sarlomo-Rikala, M.2    Andersson, L.C.3    Knuutila, S.4    Miettinen, M.5
  • 17
    • 8144222050 scopus 로고    scopus 로고
    • Loss of heterozygosity of chromosome 9p and loss of p16INK4A expression are associated with malignant gastrointestinal stromal tumors
    • Sabah M, Cummins R, Leader M, Kay E. Loss of heterozygosity of chromosome 9p and loss of p16INK4A expression are associated with malignant gastrointestinal stromal tumors. Mod Pathol 2004; 17(11):1364-71.
    • (2004) Mod Pathol , vol.17 , Issue.11 , pp. 1364-1371
    • Sabah, M.1    Cummins, R.2    Leader, M.3    Kay, E.4
  • 18
    • 3042723785 scopus 로고    scopus 로고
    • Role of p16/INK4a in gastrointestinal stromal tumor progression
    • Ricci R, Arena V, Castri F, et al. Role of p16/INK4a in gastrointestinal stromal tumor progression. Am J Clin Pathol 2004; 122(1):35-43.
    • (2004) Am J Clin Pathol , vol.122 , Issue.1 , pp. 35-43
    • Ricci, R.1    Arena, V.2    Castri, F.3
  • 19
    • 19944427609 scopus 로고    scopus 로고
    • Loss of p16 protein defines high-risk patients with gastrointestinal stromal tumors: A tissue microarray study
    • Schneider-Stock R, Boltze C, Lasota J, et al. Loss of p16 protein defines high-risk patients with gastrointestinal stromal tumors: a tissue microarray study. Clin Cancer Res 2005; 11(2 Pt 1):638-45.
    • (2005) Clin Cancer Res , vol.11 , Issue.2 PART 1 , pp. 638-645
    • Schneider-Stock, R.1    Boltze, C.2    Lasota, J.3
  • 21
    • 23444443877 scopus 로고    scopus 로고
    • Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade
    • Nakamura N, Yamamoto H, Yao T, et al. Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade. Hum Pathol 2005; 36(7):828-37.
    • (2005) Hum Pathol , vol.36 , Issue.7 , pp. 828-837
    • Nakamura, N.1    Yamamoto, H.2    Yao, T.3
  • 22
    • 0031015032 scopus 로고    scopus 로고
    • Prognostic significance of DNA ploidy and proliferative index (MIB-1 index) in gastrointestinal stromal tumors
    • Carrillo R, Candia A, Rodriguez-Peralto JL, Caz V. Prognostic significance of DNA ploidy and proliferative index (MIB-1 index) in gastrointestinal stromal tumors. Hum Pathol 1997; 28(2):160-5.
    • (1997) Hum Pathol , vol.28 , Issue.2 , pp. 160-165
    • Carrillo, R.1    Candia, A.2    Rodriguez-Peralto, J.L.3    Caz, V.4
  • 23
    • 0036329780 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumor: Consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade
    • Hasegawa T, Matsuno Y, Shimoda T, Hirohashi S. Gastrointestinal stromal tumor: consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade. Hum Pathol 2002; 33(6):669-76.
    • (2002) Hum Pathol , vol.33 , Issue.6 , pp. 669-676
    • Hasegawa, T.1    Matsuno, Y.2    Shimoda, T.3    Hirohashi, S.4
  • 24
    • 0031904592 scopus 로고    scopus 로고
    • Immunophenotype, proliferation, DNA ploidy, and biological behavior of gastrointestinal stromal tumors: A multivariate clinicopathologic study
    • Rudolph P, Gloeckner K, Parwaresch R, Harms D, Schmidt D. Immunophenotype, proliferation, DNA ploidy, and biological behavior of gastrointestinal stromal tumors: a multivariate clinicopathologic study. Hum Pathol 1998; 29(8):791-800.
    • (1998) Hum Pathol , vol.29 , Issue.8 , pp. 791-800
    • Rudolph, P.1    Gloeckner, K.2    Parwaresch, R.3    Harms, D.4    Schmidt, D.5
  • 25
    • 10744233692 scopus 로고    scopus 로고
    • Prognostic indicators for gastrointestinal stromal tumours: A clinicopathological and immunohistochemical study of 108 resected cases of the stomach
    • Wong NA, Young R, Malcomson RD, et al. Prognostic indicators for gastrointestinal stromal tumours: a clinicopathological and immunohistochemical study of 108 resected cases of the stomach. Histopathology 2003; 43(2):118-26.
    • (2003) Histopathology , vol.43 , Issue.2 , pp. 118-126
    • Wong, N.A.1    Young, R.2    Malcomson, R.D.3
  • 27
    • 0642276749 scopus 로고    scopus 로고
    • Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer
    • Gonzalez MA, Pinder SE, Callagy G, et al. Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer. J Clin Oncol 2003; 21(23):4306-13.
    • (2003) J Clin Oncol , vol.21 , Issue.23 , pp. 4306-4313
    • Gonzalez, M.A.1    Pinder, S.E.2    Callagy, G.3
  • 28
    • 13644268795 scopus 로고    scopus 로고
    • Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathology
    • Tachibana KE, Gonzalez MA, Coleman N. Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathology. J Pathol 2005; 205(2):123-9.
    • (2005) J Pathol , vol.205 , Issue.2 , pp. 123-129
    • Tachibana, K.E.1    Gonzalez, M.A.2    Coleman, N.3
  • 29
    • 0034024982 scopus 로고    scopus 로고
    • The location of pKi67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle
    • MacCallum DE, Hall PA. The location of pKi67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle. J Pathol 2000; 190(5):537-44.
    • (2000) J Pathol , vol.190 , Issue.5 , pp. 537-544
    • MacCallum, D.E.1    Hall, P.A.2
  • 30
    • 20344396122 scopus 로고    scopus 로고
    • Preventing re-replication of chromosomal DNA
    • Blow JJ, Dutta A. Preventing re-replication of chromosomal DNA. Nat Rev Mol Cell Biol 2005; 6(6):476-486.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.6 , pp. 476-486
    • Blow, J.J.1    Dutta, A.2
  • 31
    • 0042191801 scopus 로고    scopus 로고
    • A new proliferation marker, minichromosome maintenance protein 2, is associated with tumor aggressiveness in esophageal squamous cell carcinoma
    • Kato H, Miyazaki T, Fukai Y, et al. A new proliferation marker, minichromosome maintenance protein 2, is associated with tumor aggressiveness in esophageal squamous cell carcinoma. J Surg Oncol 2003; 84(1):24-30.
    • (2003) J Surg Oncol , vol.84 , Issue.1 , pp. 24-30
    • Kato, H.1    Miyazaki, T.2    Fukai, Y.3
  • 32
    • 31544465982 scopus 로고    scopus 로고
    • Skp2 overexpression is highly representative of intrinsic biological aggressiveness and independently associated with poor prognosis in primary localized myxofibrosarcomas
    • Huang HY, Kang HY, Li CF, Eng HL, Chou SC, Lin CN, Hsiung CY. Skp2 overexpression is highly representative of intrinsic biological aggressiveness and independently associated with poor prognosis in primary localized myxofibrosarcomas. Clin Cancer Res 2006; 12(2):487-98.
    • (2006) Clin Cancer Res , vol.12 , Issue.2 , pp. 487-498
    • Huang, H.Y.1    Kang, H.Y.2    Li, C.F.3    Eng, H.L.4    Chou, S.C.5    Lin, C.N.6    Hsiung, C.Y.7
  • 33
    • 27244449307 scopus 로고    scopus 로고
    • Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: Evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications
    • Powell EL, Leoni LM, Canto MI, et al. Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications. Am J Surg Pathol 2005; 29(11):1497-504.
    • (2005) Am J Surg Pathol , vol.29 , Issue.11 , pp. 1497-1504
    • Powell, E.L.1    Leoni, L.M.2    Canto, M.I.3
  • 35
    • 0032955439 scopus 로고    scopus 로고
    • Prognosis of gastrointestinal smooth-muscle (stromal) tumors: Dependence on anatomic site
    • Emory TS, Sobin LH, Lukes L, Lee DH, O'Leary TJ. Prognosis of gastrointestinal smooth-muscle (stromal) tumors: dependence on anatomic site. Am J Surg Pathol 1999; 23(1):82-7.
    • (1999) Am J Surg Pathol , vol.23 , Issue.1 , pp. 82-87
    • Emory, T.S.1    Sobin, L.H.2    Lukes, L.3    Lee, D.H.4    O'Leary, T.J.5
  • 36
    • 33646685694 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors of the jejunum and ileum: A clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up
    • Miettinen M, Makhlouf H, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up. Am J Surg Pathol 2006; 30(4):477-89.
    • (2006) Am J Surg Pathol , vol.30 , Issue.4 , pp. 477-489
    • Miettinen, M.1    Makhlouf, H.2    Sobin, L.H.3    Lasota, J.4
  • 37
    • 13444270334 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era - A population-based study in western Sweden
    • Nilsson B, Bumming P, Meis-Kindblom JM, et al. Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era - a population-based study in western Sweden. Cancer 2005; 103(4):821-9.
    • (2005) Cancer , vol.103 , Issue.4 , pp. 821-829
    • Nilsson, B.1    Bumming, P.2    Meis-Kindblom, J.M.3
  • 38
    • 0033984319 scopus 로고    scopus 로고
    • Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival
    • DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg 2000; 231(1):51-8.
    • (2000) Ann Surg , vol.231 , Issue.1 , pp. 51-58
    • DeMatteo, R.P.1    Lewis, J.J.2    Leung, D.3    Mudan, S.S.4    Woodruff, J.M.5    Brennan, M.F.6
  • 39
    • 0026504486 scopus 로고
    • A flow cytometric, clinical, and histological study of stromal neoplasms of the gastrointestinal tract
    • Cooper PN, Quirke P, Hardy GJ, Dixon MF. A flow cytometric, clinical, and histological study of stromal neoplasms of the gastrointestinal tract. Am J Surg Pathol 1992; 16(2):163-70.
    • (1992) Am J Surg Pathol , vol.16 , Issue.2 , pp. 163-170
    • Cooper, P.N.1    Quirke, P.2    Hardy, G.J.3    Dixon, M.F.4
  • 40
    • 14844314779 scopus 로고    scopus 로고
    • The expression of p53 and bcl-2 in gastrointestinal stromal tumours is associated with anatomical site, and p53 expression is associated with grade and clinical outcome
    • Feakins RM. The expression of p53 and bcl-2 in gastrointestinal stromal tumours is associated with anatomical site, and p53 expression is associated with grade and clinical outcome. Histopathology 2005; 46(3):270-9.
    • (2005) Histopathology , vol.46 , Issue.3 , pp. 270-279
    • Feakins, R.M.1
  • 41
    • 0037106370 scopus 로고    scopus 로고
    • Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors
    • Singer S, Rubin BP, Lux ML, Chen CJ, Demetri GD, Fletcher CD, Fletcher JA. Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors. J Clin Oncol 2002; 20(18):3898-905.
    • (2002) J Clin Oncol , vol.20 , Issue.18 , pp. 3898-3905
    • Singer, S.1    Rubin, B.P.2    Lux, M.L.3    Chen, C.J.4    Demetri, G.D.5    Fletcher, C.D.6    Fletcher, J.A.7
  • 42
    • 20544445201 scopus 로고    scopus 로고
    • 9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations
    • Perrone F, Tamborini E, Dagrada GP, et al. 9p21 locus analysis in high-risk gastrointestinal stromal tumors characterized for c-kit and platelet-derived growth factor receptor alpha gene alterations. Cancer 2005; 104(1):159-69.
    • (2005) Cancer , vol.104 , Issue.1 , pp. 159-169
    • Perrone, F.1    Tamborini, E.2    Dagrada, G.P.3
  • 43
    • 0034103810 scopus 로고    scopus 로고
    • Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma
    • Straume O, Sviland L, Akslen LA. Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma. Clin Cancer Res 2000; 6(5):1845-53.
    • (2000) Clin Cancer Res , vol.6 , Issue.5 , pp. 1845-1853
    • Straume, O.1    Sviland, L.2    Akslen, L.A.3
  • 44
    • 0030610586 scopus 로고    scopus 로고
    • Loss of expression of the p16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stage
    • Talve L, Sauroja I, Collan Y, Punnonen K, Ekfors T. Loss of expression of the p16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stage. Int J Cancer 1997; 74(3):255-9.
    • (1997) Int J Cancer , vol.74 , Issue.3 , pp. 255-259
    • Talve, L.1    Sauroja, I.2    Collan, Y.3    Punnonen, K.4    Ekfors, T.5
  • 45
    • 0033979559 scopus 로고    scopus 로고
    • Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis
    • Salvesen HB, Das S, Akslen LA. Loss of nuclear p16 protein expression is not associated with promoter methylation but defines a subgroup of aggressive endometrial carcinomas with poor prognosis. Clin Cancer Res 2000; 6(1):153-9.
    • (2000) Clin Cancer Res , vol.6 , Issue.1 , pp. 153-159
    • Salvesen, H.B.1    Das, S.2    Akslen, L.A.3
  • 46
    • 0036230171 scopus 로고    scopus 로고
    • Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): Additional evidence for a recently proposed model of progression
    • Klein WM, Hruban RH, Klein-Szanto AJ, Wilentz RE. Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia (PanIN): additional evidence for a recently proposed model of progression. Mod Pathol 2002; 15(4):441-7.
    • (2002) Mod Pathol , vol.15 , Issue.4 , pp. 441-447
    • Klein, W.M.1    Hruban, R.H.2    Klein-Szanto, A.J.3    Wilentz, R.E.4
  • 47
    • 0032578509 scopus 로고    scopus 로고
    • Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
    • Belinsky SA, Nikula KJ, Palmisano WA, et al. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci USA 1998; 95(20):11891-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.20 , pp. 11891-11896
    • Belinsky, S.A.1    Nikula, K.J.2    Palmisano, W.A.3
  • 48
    • 3042679657 scopus 로고    scopus 로고
    • Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas
    • Lee JH, Park SJ, Abraham SC, et al. Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas. Oncogene 2004; 23(26):4646-54.
    • (2004) Oncogene , vol.23 , Issue.26 , pp. 4646-4654
    • Lee, J.H.1    Park, S.J.2    Abraham, S.C.3
  • 49
    • 21644459382 scopus 로고    scopus 로고
    • Hypermethylation of the p16 gene in normal oral mucosa of smokers
    • von Zeidler SV, Miracca EC, Nagai MA, Birman EG. Hypermethylation of the p16 gene in normal oral mucosa of smokers. Int J Mol Med 2004; 14(5):807-11.
    • (2004) Int J Mol Med , vol.14 , Issue.5 , pp. 807-811
    • Von Zeidler, S.V.1    Miracca, E.C.2    Nagai, M.A.3    Birman, E.G.4


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