Bikunin inhibits lipopolysaccharide-induced tumor necrosis factor alpha induction in macrophages

Clinical and Diagnostic Laboratory Immunology

Volumn 11, Issue 6, 2004, Pages 1140-1147

  Matsuzaki, Hidenori ^a   Kobayashi, Hiroshi ^b,c   Yagyu, Tatsuo ^a   Wakahara, Kiyoshi ^a   Kondo, Toshiharu ^b   Kurita, Noriyuki ^d   Sekino, Hideo ^d   Inagaki, Kiyokazu ^a   Suzuki, Mika ^c   Kanayama, Naohiro ^c   Terao, Toshihiko ^c  

^a NetForce Co Ltd   (Japan)

^b Comp Technol Intgn ^*  (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOYOHASHI UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; ULINASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; ENZYME PHOSPHORYLATION; IN VIVO STUDY; INHIBITION KINETICS; LETHALITY; MACROPHAGE; MACROPHAGE ACTIVATION; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SURVIVAL; TIME; UPREGULATION;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MEMBRANE GLYCOPROTEINS; MICE; SERINE PROTEINASE INHIBITORS; TRYPSIN INHIBITOR, KUNITZ SOYBEAN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 9144263738     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/CDLI.11.6.1140-1147.2004     Document Type: Article

References (35)

1. Aggarwal, B. B., and K. Natarajan. 1996. Tumor necrosis factors: developments during the last decade. Eur. Cytokine Netw. 7:93-124.
2. Aibiki, M., and J. A. Cook. 1997. Ulinastatin, a human trypsin inhibitor, inhibits endotoxin-induced thromboxane B2 production in human monocytes. Crit. Care Med. 25:430-434.
3. Beutler, B. 1992. Tumor necrosis factors: the molecules and their emerging role in medicine. Raven Press, New York, N.Y.
4. Collart, M., P. Bauerle, and P. Vassalli. 1990. Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol. Cell. Biol. 10:1498-1506.
5. Dankesreiter, S., A. Hoess, J. Schneider-Mergener, H. Wagner, and T. Miethke. 2000. Synthetic endotoxin-binding peptides block endotoxin-triggered TNF-α production by macrophages in vitro and in vivo and prevent endotoxin-mediated toxic shock. J. Immunol. 164:4804-4811.
6. Dumitru, C. D., J. D. Ceci, C. Tsatsanis, D. Kontoyiannis, K. Stamatakis, J.-H. Lin, C. Patriotis, N. A. Jenkins, N. G. Copeland, G. Kollias, and P. N. Tsichlis. 2000. TNF-α induction by LPS is regulated posttranscriptionally via a Tp12/ERK-dependent pathway. Cell 103:1071-1083.
7. Feldmann, M., and R. N. Maini. 2001. Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu. Rev. Immunol. 19:163-196.
8. Fries, E., and A. Kaczmarczyk. 2003. Inter-α-inhibitor, hyaluronan and inflammation. Acta Biochim. Polonica 50:735-742.
9. Futamura, Y., S. Kajikawa, N. Kaga, and Y. Shibutani. 1999. Protection against preterm delivery in mice by urinary trypsin inhibitor. Obstet. Gynecol. 93:100-108.
10. Galanos, C., M. A. Freudenberg, and W. Reutter. 1979. Galactosamine-induced sensitization of the lethal effects of endotoxin. Proc. Natl. Acad. Sci. USA 76:5939-5943.
11. Inamo, Y., T. Okubo, M. Wada, S. Fuchigami, K. Hashimoto, T. Fuchigami, S. Takahashi, S. Sawada, and K. Harada. 2002. Intravenous ulinastatin therapy for Stevens-Johnson syndrome and toxic epidermal necrolysis in pediatric patients. Three case reports. Int. Arch. Allergy Immunol. 127:89-94.
12. Keppler, D. O., J. Pausch, and K. Decker. 1974. Selective uridine triphosphate deficiency induced by D-galactosamine in liver and reversed by pyrimidine nucleotide precursors. Effect on ribonucleic acid synthesis. J. Biol. Chem. 249:211-216.
13. Kobayashi, H., H. Shinohara, J. Gotoh, M. Fujie, S. Fujishiro, and T. Terao. 1995. Anti-metastatic therapy by urinary trypsin inhibitor in combination with an anti-cancer agent. Br. J. Cancer 72:1131-1137.
14. Kobayashi, H., M. Suzuki, N. Kanayama. T. Nishida, M. Takigawa, and T. Terao. 2002. Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade. Eur. J. Biochem. 269:3945-3957.
15. Kobayashi, H., M. Suzuki, Y. Hirashima, and T. Terao. 2003. The protease inhibitor bikunin, a novel anti-metastatic agent. Biol. Chem. 384:749-754.
16. Kobayashi, H., M. Suzuki, Y. Tanaka, Y. Hirashima, and T. Terao. 2001. Suppression of urokinase expression and invasiveness by urinary trypsin inhibitor is mediated through inhibition of protein kinase C- and MEK/ERK/c-Jun-dependent signaling pathways. J. Biol. Chem. 276:2015-2022.
17. Kobayashi, H., T. Yagyu, K. Inagaki, T. Kondo, M. Suzuki, N. Kanayama, and T. Terao. 2004. Bikunin plus paclitaxel markedly reduces tumor burden and ascites in mouse model of ovarian cancer. Int. J. Cancer 110:134-139.
18. Kobayashi, H., T. Yagyu, K. Inagaki, T. Kondo, M. Suzuki, N. Kanayama, and T. Terao. 2004. Therapeutic efficacy of once-daily oral administration of a Kunitz-type protease inhibitor, bikunin, in a mouse model and in human cancer. Cancer 100:869-877.
19. Laskin, D. L., and K. J. Pendino. 1995. Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. Toxicol. 35:655-677.
20. Lim, Y. P., K. Bendelja, S. M. Opal, E. Siryaporn, D. C. Hixson, and J. E. Palardy. 2003. Correlation between mortality and the levels of inter-alpha inhibitors in the plasma of patients with severe sepsis. J. Infect. Dis. 188:919-926.
21. Locksley, R. M., N. Killeen, and M. J. Lenardo. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487-501.
22. Luster, M. I. 1998. Inflammation, tumor necrosis factor, and toxicology. Environ. Health Perspect. 106:A418-A419.
23. Ma, O., and K. Kinneer. 2002. Chemoprotection by phenolic antioxidants. Inhibition of tumor necrosis factor alpha induction in macrophages. J. Biol. Chem. 277:2477-2484.
24. Mijatovic, T., V. Kruys, D. Caput, P. Defrance, and G. Huez. 1997. Interleukin-4 and -13 inhibit tumor necrosis factor-α mRNA translational activation in lipopolysaccharide-induced mouse macrophages. J. Biol. Chem. 272:14394-14398.
25. Newton, R. C. 1986. Human monocyte production of IL-1: parameters of the induction of IL-1 secretion by lipopolysaccharides. J. Leukoc. Biol. 39:299-311.
26. Onai, H., and S. Kudo. 2001. Suppression of superantigen-induced lung injury and vasculitis by preadministration of human urinary trypsin inhibitor. Eur. J. Clin. Investig. 31:272-280.
27. Read, M. A., M. Z. Whitly, A. J. Williams, and T. Collins. 1994. NF-κB and κBα: an inducible regulatory system in endothelial activation. J. Exp. Med. 179:503-512.
28. Roger, T., J. David, M. P. Glauser, and T. Calandra. 2001. 2001. MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 414:920-924.
29. Scherle, P. A., E. A. Jones, M. F. Favata, A. J. Daulerio, M. B. Covington, S. A. Nurnberg, R. L. Magolda, and J. M. Trzaskos. 1998. Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes. J. Immunol. 161:5681-5686.
30. Shimanuki, K., and M. Satake. 1999. Evaluation of perioperative administration of methylprednisolone sodium succinate and urinary trypsin inhibitor for prevention of surgical stress. Fukushima J. Med. Sci. 45:93-107.
31. Suzuki, M., H. Kobayashi, M. Fujie, T. Nishida, M. Takigawa, N. Kanayama, and T. Terao. 2002. Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells. J. Biol. Chem. 277:8022-8032.
32. Suzuki, M., H. Kobayashi, Y. Tanaka, Y. Hirashima, and T. Terao. 2001. Structure and function analysis of urinary trypsin inhibitor (UTI): identification of binding domains and signaling property of UTI by analysis of truncated proteins. Biochim. Biophys. Acta 1547:26-36.
33. Suzuki, M., H. Kobayashi, Y. Tanaka, Y. Hirashima, N. Kanayama, Y. Takei, Y. Saga, M. Suzuki, H. Itoh, and T. Terao. 2003. Bikunin target genes in ovarian cancer cells identified by microarray analysis. J. Biol. Chem. 278:14640-14646.
34. Van der Meide, P. H., and H. Schellekens. 1996. Cytokines and the immune response. Biotherapy 8:243-249.
35. Yang, S., Y. P. Lim, M. Zhou, P. Salvemini, H. Schwinn, D. Josic, D. J. Koo, I. H. Chaudry, and P. Wang. 2002. Administration of human inter-α-inhibitors maintains hemodynamic stability and improves survival during sepsis. Crit. Care Med. 30:617-622.