Perianal Paget's disease: A histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma

American Journal of Surgical Pathology

Volumn 22, Issue 2, 1998, Pages 170-179

  Goldblum, John R ^a   Hart, William R ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Cytokeratin 20; Cytokeratin 7; Extramammary Paget's disease; Gross cystic disease fluid protein 15; Immunohistochemistry; Perianal Paget's disease

Indexed keywords

CYTOKERATIN;

ADULT; AGED; ANUS CARCINOMA; ARTICLE; CANCER RECURRENCE; CLINICAL ARTICLE; DISEASE ASSOCIATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PAGET SKIN DISEASE; RECTUM CARCINOMA; SKIN CARCINOMA;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; KERATIN-20; KERATIN-7; KERATINS; MALE; MIDDLE AGED; PAGET'S DISEASE, EXTRAMAMMARY; RECTAL NEOPLASMS;

EID: 0031889885     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199802000-00004     Document Type: Article

References (19)

1. Armitage NC, Jass JR, Richman PI, Thomson JPS, Phillips RKS. Paget's disease of the anus: a clinicopathological study, Br J Surg 1989;76:60-3.
2. Beck DE, Fazio VW. Perianal Paget's disease. Dis Colon Rectum 1987;30:263-6.
3. Berardi RS, Lee S, Chen HP. Perianal extramammary Paget's disease. Surg Gynecol Ohstet 1988;167:359-66.
4. Berezowski K, Stastny JF, Kornstein MJ. Cytokeratins 7 and 20 and carcinoembryonic antigen in ovarian and colonic carcinoma. Mod Pathol 1996;9:426-9.
5. Goldblum JR, Hart WR. Vulvar Paget's disease: a clinicopathologic and immunohistochemical study of 19 cases. Am J Surg Pathol 1997;21(10):1178-87.
6. Hart WR, Millman JB. Progression of intraepithelial Paget's disease of the vulva to invasive carcinoma. Cancer 1977;40:2333-7.
7. Helwig EB, Graham JH. Anogenital (extramammary) Paget's disease: a clinicopathologic study. Cancer 1963;16:387-403.
8. Kohler S, Smoller BR. Gross cystic disease fluid protein-15 reactivity in extramammary Paget's disease with and without associated internal malignancy. Am J Dermatopathol 1996;18:118-23.
9. Lash RH, Hart WR. Intestinal adenocarcinoma metastatic to the ovaries. A clinicopathologic evaluation of 22 cases. Am J Surg Pathol 1987;11:114-21.
10. Loy PS, Calaluce RD. Utility of cytokeratin immunostaining in separating pulmonary adenocarcinomas from colonic adenocarcinomas. Am J Clin Pathol 1994;102:764-7.
11. Marchesa P, Fazio VW, Oliart S, Goldblum JR, Millsom JW. Long-term outcome of patients with perianal Paget's disease. Ann Surg Oncol (in press).
12. Miettinen M. Cytokeratin 20: immunohistochemical marker for gastrointestinal, urothelial and Merkel cell carcinomas. Mod Pathol 1995;8:384-8.
13. Ormsby AH, Snow JL, Su WPD, Goellner JR. Diagnostic immunohistochemistry of cutaneous metastatic breast carcinoma: a statistical analysis of the utility of gross cystic disease fluid protein-15 and estrogen receptor proteins. J Am Acad Dermatol 1995;32: 711-6.
14. Ramaekers FCS, van Niekerk CC, Poels LG, et al. Use of monoclonal antibodies to keratin 7 in the differential diagnosis of adenocarcinomas. Am J Pathol 1990;136:641-55.
15. van Niekerk CC, Jap PHK, Ramaekers FCS, van de Molengraft F, Poels LG. Immunohistochemical demonstration of keratin 7 in routinely fixed paraffin-embedded human tissues. J Pathol 1991; 165:145-52.
16. Wang NP, Zee S, Zarbo RJ, Bacchi CE, Gown AM. Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas. Appl Immunohistochem 1995;3:99-107.
17. Wauters CCAP, Smedts F, Gerrits LGM, Bosman FT, Ramaekers FCS. Keratin 7 and 20 as diagnostic markers of carcinomas metastatic to the ovary. Hum Pathol 1995;26:852-5.
18. Wick MR, Lillemoe TJ, Copland GT, Swanson PE, Manival JC, Kiang DT. Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin. Hum Pathol 1989; 20:281-7.
19. Williams SL, Rogers LW, Quan SH. Perianal Paget's disease: report of 7 cases. Dis Colon Rectum 1976;19:30-40.