CCR5 receptor antagonists: Discovery and SAR study of guanylhydrazone derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 1, 2007, Pages 231-234

  Wei, Robert G ^a   Arnaiz, Damian O ^a   Chou, Yuo Ling ^a   Davey, Dave ^a   Dunning, Laura ^a   Lee, Wheeseong ^a   Lu, Shou Fu ^a   Onuffer, James ^a   Ye, Bin ^a   Phillips, Gary ^a  

^a BAYER AG   (Germany)

Author keywords

CCR5; Chemokine receptor antagonists

Indexed keywords

AMIDINOHYDRAZONE; BENZALDEHYDE DERIVATIVE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; CHLORINE DERIVATIVE; PHENYL GROUP;

ARTICLE; CELL STRAIN HEK293; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; MITOGUAZONE; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845652546     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.052     Document Type: Article

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