Piperazine-based CCR5 antagonists as HIV-1 inhibitors. III: Synthesis, antiviral and pharmacokinetic profiles of symmetrical heteroaryl carboxamides

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 3, 2003, Pages 567-571

  McCombie, Stuart W ^a   Tagat, Jayaram R ^a   Vice, Susan F ^a   Lin, Sue Ing ^a   Steensma, Ruo ^a   Palani, Anandan ^a   Neustadt, Bernard R ^a   Baroudy, Bahige M ^a   Strizki, Julie M ^a   Endres, Michael ^a   Cox, Kathleen ^a   Dan, Niya ^a   Chou, Chuan Chu ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CHEMOKINE RECEPTOR CCR5; METHYL GROUP; PIPERAZINE DERIVATIVE; PYRIMIDINE CARBOXAMIDE; SCH 350634; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; DRUG ABSORPTION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; OXIDATION; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; VIRUS INACTIVATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-HIV AGENTS; AREA UNDER CURVE; CHEMISTRY, PHYSICAL; HALF-LIFE; HETEROCYCLIC COMPOUNDS; HIV-1; HUMANS; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; MOLECULAR CONFORMATION; PIPERAZINES; RATS; RECEPTORS, CCR5; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037325553     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00918-6     Document Type: Article

References (21)

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20. +): 504.2937; Found 504.2950.
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