Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 1, 2005, Pages 25-28

  Burrows, Jeremy N ^a   Cumming, John G ^a   Fillery, Shaun M ^a   Hamlin, Gordon A ^a   Hudson, Julian A ^a   Jackson, Ruth J ^a   McLaughlin, Sharon ^a   Shaw, John S ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

CCR5; Chemokine receptor modulators

Indexed keywords

ACETAMIDE DERIVATIVE; CHEMOKINE RECEPTOR CCR5; LIGAND; UREA DERIVATIVE;

ARTICLE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; HUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; HUMANS; PIPERIDINES; RECEPTORS, CCR5; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 9644265258     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.044     Document Type: Article

References (12)

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11. 125I]RANTES, SPA beads (Amersham RPNQ0001) and membranes expressing the human CCR5 receptor. The signal was read on a Packard Topcount
12. Work carried out on behalf of AstraZeneca by MDS Pharma Services, Taipei, Taiwan