Dissecting carbohydrate-Cyanovirin-N binding by structure-guided mutagenesis: Functional implications for viral entry inhibition

Protein Engineering, Design and Selection

Volumn 19, Issue 12, 2006, Pages 525-535

  Barrientos, Laura G ^a,b   Matei, Elena ^a,d   Lasala, Fátima ^c   Delgado, Rafael ^c   Gronenborn, Angela M ^a,d  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cyanovirin N; High mannose oligosaccharides; Mutant design; Viral env glycoprotein; Virucidal agent

Indexed keywords

AMINO ACIDS; CARBOHYDRATES; CROSSLINKING; ENZYME INHIBITION; MUTAGENESIS; VIRUSES;

CYANOVIRIN-N; HIGH MANNOSE OLIGOSACCHARIDES; MUTANT DESIGN; VIRAL ENV GLYCOPROTEIN; VIRUCIDAL AGENTS;

PROTEINS;

AMINO ACID; ANTIVIRUS AGENT; CYANOVIRIN N; ENVELOPE PROTEIN; GLYCAN; GLYCOPROTEIN; MANNOSE; SUGAR; VIRUS PROTEIN;

ANTIGEN ANTIBODY REACTION; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; CROSS LINKING; ENZYME SPECIFICITY; IN VITRO STUDY; MOLECULAR RECOGNITION; MUTAGENESIS; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN FUNCTION; VIRUS INHIBITION; VIRUS PARTICLE;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; BACTERIAL PROTEINS; BINDING SITES; CARBOHYDRATE SEQUENCE; CARRIER PROTEINS; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; JURKAT CELLS; MANNOSE; MANNOSE-BINDING LECTINS; MANNOSIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; VIRUS INTERNALIZATION;

CYANOBACTERIA;

EID: 33845632976     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzl040     Document Type: Article

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