Oral administration of phenolic antidiarrheic ingredients prevents ovariectomy-induced bone loss

Biochemical Pharmacology

Volumn 73, Issue 3, 2007, Pages 385-393

  Moriguchi, Nobuaki ^a,b   Hinoi, Eiichi ^a   Takarada, Takeshi ^a   Matsushima, Nobuyuki ^a,b   Uno, Kyosuke ^a   Yoneda, Yukio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b Taiko Pharmaceutical Co Ltd   (Japan)

Author keywords

Antidiarrheic; Bone loss; Osteoblasts; Osteoclasts; Ovariectomy

Indexed keywords

2 METHOXY 4 ETHYLPHENOL; 4 ETHYLPHENOL; ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ANTIDIARRHEAL AGENT; COLONY STIMULATING FACTOR 1; CREOSOL; ESTRADIOL; GUAIACOL; HYDROGEN PEROXIDE; OSTEOCLAST DIFFERENTIATION FACTOR; PARA CRESOL; PHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; CALVARIA; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; FEMUR; MORPHOMETRICS; MOUSE; MULTINUCLEAR CELL; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OVARIECTOMY; PRIORITY JOURNAL; TIBIA;

ADMINISTRATION, ORAL; ANIMALS; ANTIDIARRHEALS; ANTIOXIDANTS; BONE DENSITY; CELLS, CULTURED; CRESOLS; FEMALE; GUAIACOL; HYDROGEN PEROXIDE; MACROPHAGE COLONY-STIMULATING FACTOR; MICE; OSTEOCLASTS; OSTEOGENESIS; OVARIECTOMY; RANK LIGAND; REACTIVE OXYGEN SPECIES;

EID: 33845619111     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.09.025     Document Type: Article

References (30)

1. Harada S., and Rodan G.A. Control of osteoblast function and regulation of bone mass. Nature 423 (2003) 349-355
2. Boyle W.J., Simonet W.S., and Lacey D.L. Osteoclast differentiation and activation. Nature 423 (2003) 337-342
3. Teitelbaum S.L. Bone resorption by osteoclasts. Science 289 (2000) 1504-1508
4. Chien K.R., and Karsenty G. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell 120 (2005) 533-544
5. Masi L., and Brandi M.L. Physiopathological basis of bone turnover. Quart J Nucl Med 45 (2001) 2-6
6. Hock J.M., Krishnan V., Onyia J.E., Bidwell J.P., Milas J., and Stanislaus D. Osteoblast apoptosis and bone turnover. J Bone Miner Res 16 (2001) 975-984
7. Delaisse J.M., Eeckhout Y., and Vaes G. Inhibition of bone resorption in culture by (+)-catechin. Biochem Pharmacol 35 (1986) 3091-3094
8. Horcajada-Molteni M.N., Crespy V., Coxam V., Davicco M.J., Remesy C., and Barlet J.P. Rutin inhibits ovariectomy-induced osteopenia in rats. J Bone Miner Res 15 (2000) 2251-2258
9. Park Y.H., Han D.W., Suh H., Ryu G.H., Hyon S.H., Cho B.K., et al. Protective effects of green tea polyphenol against reactive oxygen species-induced oxidative stress in cultured rat calvarial osteoblast. Cell Biol Toxicol 19 (2003) 325-337
10. Puel C., Quntin A., Agalias A., Mathey J., Obled C., Mazur A., et al. Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovarietomised rat. Br J Nutr 92 (2004) 119-127
11. Puel C., Quntin J., Mathey J., Obled C., Davicco M.J., Lebecque P., et al. Prevention of bone loss by phloridzin, an apple polyphenol, in ovariectomized rats under inflammatory conditions. Calcif Tissue Int 77 (2005) 311-318
12. Hinoi E., Takarada T., Tsuchihashi Y., Fujimori S., Moriguchi N., Wang L., et al. A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol Pharmacol 70 (2006) 925-935
13. Abu-Amer Y., Ross F.P., McHugh K.P., Lovolsi A., Peyron J.F., and Teitelbaum S.L. Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha. J Biol Chem 273 (1998) 29417-29423
14. Hinoi E., Fujimori S., and Yoneda Y. Modulation of cellular differentiation by N-methyl-d-aspartate receptors in osteoblasts. FASEB 17 (2003) 1532-1534
15. Hinoi E., Fujimori S., Takemori A., and Yoneda Y. Cell death by pyruvate deficiency in proliferative cultured calvarial osteoblasts. Biochem Biophys Res Commun 294 (2002) 1177-1183
16. Moriguchi N., Hinoi E., Tsuchihashi Y., Fujimori S., Iemata M., Takarada T., et al. Cytoprotection by pyruvate through an anti-oxidative mechanism in cultured rat calvarial osteoblasts. Histol Histopathol 21 (2006) 969-977
17. Turnbull S., Tabner B.J., El-Agnaf O.M., Moore S., Davies Y., and Allsop D. alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro. Free Radic Biol Med 30 (2001) 1163-1170
18. Yazaki K., Mimura T., and Kawaguchi M. Activating effects of phenolic compounds on the osteogenic cell line. Bull Tokyo Dent Coll 34 (1993) 141-145
19. Mimurai T., Yazaki K., Sawaki K., Ozawa T., and Kawaguchi M. Hydroxyl radical scavenging effects of guaiacol used in traditional dental pulp sedation: reaction kinetic study. Biomed Res 26 (2005) 139-145
20. Basu S., Michaelsson K., Olofsson H., Johansson S., and Melhus H. Association between oxidative stress and bone mineral density. Biochem Biophys Res Commun 288 (2001) 275-279
21. Maggio D., Barabani M., Pierandrei M., Macchiarulo M.C., Cecchetti R., Pedrazzoni M., et al. Antioxidants and bone turnover in involutional osteoporosis. J Endocrinol Invest 25 (2002) 101-102
22. Lean J.M., Davies J.T., Fuller K., Jagger C.J., Kirstein B., Partington G.A., et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 112 (2003) 915-923
23. Lean J.M., Jagger C.J., Kirstein B., Fuller K., and Chambers T.J. Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology 146 (2005) 728-735
24. Felix R., Cecchini M.G., Hofstetter W., Elford P.R., Stutzer A., and Fleisch H. Impairment of macrophage colony stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op mouse. J Bone Miner Res 5 (1990) 781-789
25. Yoshida H., Hayashi S., Kunisada T., Ogawa M., Nishikawa S., Okamura H., et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345 (1990) 442-444
26. Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Mochizuki S., et al. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95 (1998) 3597-3602
27. Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 (1998) 165-176
28. Garrett I.R., Boyce B.F., Oreffo R.O., Bonewald L., Poser J., and Mundy G.R. Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85 (1990) 632-639
29. Bax B.E., Alam A.S., Banerji B., Bax C.M., Bevis P.J., Stevens C.R., et al. Stimulation of osteoclastic bone resorption by hydrogen peroxide. Biochem Biophys Res Commun 183 (1992) 1153-1158
30. Finkel T., and Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 408 (2000) 239-247