Pleiotropic QTL on chromosome 12q23-q24 influences triglyceride and high-density lipoprotein cholesterol levels: The HERITAGE family study

Human Biology

Volumn 78, Issue 3, 2006, Pages 317-327

  Feitosa, Mary F ^a   Rice, Treva ^a   Borecki, Ingrid B ^a   Rankinen, Tuomo ^b   Leon, Arthur S ^c   Skinner, James S ^d   Després, Jean Pierre ^e,f   Blangero, John ^g   Bouchard, Claude ^b   Rao, D C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d INDIANA UNIVERSITY   (United States)

^e UNIVERSITÉ LAVAL   (Canada)

^f LAVAL UNIVERSITY   (Canada)

^g SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Bivariate linkage analysis; Coronary heart disease; High density lipoprotein (HDL); Insulin like growth factor 1 (IGF1); Lipid; Lipoprotein; Quantitative trait loci; Triglycerides

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; SOMATOMEDIN C; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 12Q; CHROMOSOME ANALYSIS; DNA POLYMORPHISM; FAMILY; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC LINKAGE; GENETIC MARKER; HUMAN; HUMAN EXPERIMENT; INSULIN LIKE GROWTH FACTOR 1 GENE; LINKAGE ANALYSIS; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MARKER GENE; MULTIVARIATE ANALYSIS; NORMAL HUMAN; PHENOTYPE; PLASMA; PLEIOTROPY; QUANTITATIVE TRAIT LOCUS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL; UNIVARIATE ANALYSIS;

EID: 33845569867     PISSN: 00187143     EISSN: None     Source Type: Journal    
DOI: 10.1353/hub.2006.0043     Document Type: Article

References (31)

1. Almasy, L., and J. Blangero. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 62:1198-1211.
2. Almasy, L., T. D. Dyer, and J. Blangero. 1997. Bivariate quantitative trait linkage analysis: Pleiotropy versus co-incident linkages. Genet. Epidemiol. 14:953-958.
3. Almasy, L., J. E. Hixson, D. L. Rainwater et al. 1999. Human pedigree-based quantitative-trait-locus mapping: Localization of two genes influencing HDL-cholesterol metabolism. Am. J. Hum. Genet. 64:1686-1693.
4. Amos, C., M. de Andrade, and D. Zhu. 2001. Comparison of multivariate tests for genetic linkage. Hum. Hered. 51:133-144.
5. Ashen, M. D., and R. S. Blumenthal. 2005. Clinical practice: Low HDL cholesterol levels. New Engl. J. Med. 353:1252-1260.
6. Benjamini, Y., and Y. Hochberg. 1995. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. R. Stat. Soc. 85:289-300.
7. Bouchard, C., A. S. Leon, D. C. Rao et al. 1995. The HERITAGE family study: Aims, design, and measurement protocol. Med. Sci. Sports Exerc. 27:721-729.
8. Burstein, M., and J. Samaille. 1960. Sur un dosage rapide du cholestérol lie aux B-lipoprotéins du sérum. Clin. Chim. Acta 5:609-610.
9. Carmena, R., P. Duriez, and J. C. Fruchart. 2004. Atherogenic lipoprotein particles in atherosclerosis. Circulation 109(3):2-7.
10. Chagnon, Y. C., T. Rice, L. Pérusse et al. 2001. Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE. J. Appl. Physiol. 90:1777-1787.
11. Cohen, J. C., R. S. Kiss, A. Pertsemlidis et al. 2004. Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science 305:869-872.
12. Colao, A., S. Spiezia, C. Di Somma et al. 2005. Circulating insulin-like growth factor I levels are correlated with the atherosclerotic profile in healthy subjects independently of age. J. Endocrinol. Invest. 28:440-448.
13. Connelly, M. A., and D. J. Williams. 2004. Scavenger receptor BI: A scavenger receptor with a mission to transport high density lipoprotein lipids. Curr. Opin. Lipidol. 15:287-295.
14. Desbuquois, B., and G. D. Aurbach. 1971. Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J. Clin. Endocrinol. Metab. 33:732-738.
15. Després, J. P., J. Gagnon, J. Bergeron et al. 1999. Plasma post-heparin lipase activities in the HERITAGE Family Study: The reproducibility, gender differences, and associations with lipoprotein levels-HEalth, Risk factors, exercise Training and GEnetics. Clin. Biochem. 32:157-165.
16. Eckardstein, A., M. Hersberger, and L. Rohrer. 2005. Current understanding of the metabolism and biological actions of HDL. Curr. Opin. Clin. Nutr. Metab. Care 8:147-152.
17. Feitosa, M. F., T. Rice, K. E. North et al. 2006. Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: The HERITAGE Family Study. Atherosclerosis 185:426-432.
18. Feitosa, M. F., T. Rice, T. Rankinen et al. 2005a. Common genetic and environmental effects on lipid phenotypes: The HERITAGE family study. Hum. Hered. 59:34-40.
19. Feitosa, M. F., T. Rice, T. Rankinen et al. 2005b. Evidence of QTLs on chromosomes 13q, 14q, and 10p for triglycerides before and after 20 weeks of exercise training: The HERITAGE Family Study. Atherosclerosis 182:349-360.
20. Hokanson, J. E., C. D. Langefeld, B. D. Mitchell et al. 2003. Pleiotropy and heterogeneity in the expression of atherogenic lipoproteins: The IRAS Family Study. Hum. Hered. 55:46-50.
21. Klos, K. L., S. L. Kardia, R. E. Ferrell et al. 2001. Genome-wide linkage analysis reveals evidence of multiple regions that influence variation in plasma lipid and apolipoprotein levels associated with risk of coronary heart disease. Arterioscler. Thromb. Vasc. Biol. 21:971-978.
22. Leon, A. S., T. Rice, S. Mandel et al. 2000. Blood lipid response to 20 weeks of supervised exercise in a large biracial population: The HERITAGE Family Study. Metabolism 49:513-520.
23. Lin, J. P. 2003. Genome-wide scan on plasma triglyceride and high density lipoprotein cholesterol levels, accounting for the effects of correlated quantitative phenotypes. BMC Genet. 4:S47.
24. Martinez, L. O., S. Jacquet, F. Terce et al. 2004. New insight on the molecular mechanisms of high-density lipoprotein cellular interactions. Cell Mol. Life Sci. 61:2343-2360.
25. Ng, M. C., W. Y. So, V. K. Lam et al. 2004. Genome-wide scan for metabolic syndrome and related quantitative traits in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25. Diabetes 53:2676-2683.
26. Nielsen, E. M., L. Hansen, M. Lajer et al. 2004. A common polymorphism in the promoter of the IGF-I gene associates with increased fasting serum triglyceride levels in glucose-tolerant subjects. Clin. Biochem. 37:660-665.
27. Reed, D. R., E. Nanthakumar, M. North et al. 2001. A genome-wide scan suggests a locus on chromosome 1q21-q23 contributes to normal variation in plasma cholesterol concentration. J. Mol. Med. 79:262-269.
28. Reich, D. E., and E. S. Lander. 2001. On the allelic spectrum of human disease. Tr. Genet. 17:502-510.
29. Sun, G., J. Gagnon, Y. C. Chagnon et al. 1999. Association and linkage between an insulin-like growth factor 1 gene polymorphism and fat free mass in the HERITAGE Family Study. Int. J. Obes. Relat. Metab. Disord. 23:929-935.
30. Temelkova-Kurktschiev, T., and M. Hanefeld. 2004. The lipid triad in type 2 diabetes: Prevalence and relevance of hypertriglyceridaemia/low high-density lipoprotein syndrome in type 2 diabetes. Exp. Clin. Endocrinol. Diabetes 112:75-79.
31. Williams, J. T., H. Begleiter, B. Porjesz et al. 1999. Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. Am. J. Hum. Genet. 65:1148-1160.