Genome-wide linkage analysis reveals evidence of multiple regions that influence variation in plasma lipid and apolipoprotein levels associated with risk of coronary heart disease

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 6, 2001, Pages 971-978

  Klos, Kathy L ^a   Kardia, Sharon L R ^a   Ferrell, Robert E ^a   Turner, Stephen T ^a   Boerwinkle, Eric ^a   Sing, Charles F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apolipoprotein A I; Apolipoprotein A II; Apolipoprotein E; Genetic linkage; High density lipoproteins; Total cholesterol

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN A1; APOLIPOPROTEIN A2; APOLIPOPROTEIN B; APOLIPOPROTEIN C2; APOLIPOPROTEIN C3; APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CHROMOSOME 11; CHROMOSOME 12; CHROMOSOME 17; CHROMOSOME 19; CORONARY ARTERY DISEASE; FEMALE; GENETIC LINKAGE; GENOME; HUMAN; HYPERLIPIDEMIA; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PEDIGREE ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RISK FACTOR;

EID: 0035717515     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.21.6.971     Document Type: Article

References (72)

1. Hypertriglyceridemia as a cardiovascular risk factor
2. Triglycerides: A risk factor for coronary heart disease
3. Atherosclerosis in inherited and acquired disorders of plasma lipoprotein metabolism
4. Serum lipid precursors of coronary heart disease
5. HDL cholesterol and other lipids in coronary heart disease: The Cooperative Lipoprotein Phenotyping Study
6. The role of lipids and lipoproteins in atherosclerosis
7. Plasma-high-density-lipoprotein concentration and development of ischaemic heart disease
8. Apolipoproteins B and A-I and coronary artery disease in humans
9. Decreased HDL2 and HDL3 cholesterol, Apo A-I and Apo A-II, and increased risk of myocardial infarction
10. Apolipoprotein E polymorphism and atherosclerosis
11. Multivariate analyses of serum apolipoproteins and risk factors in relation to acute myocardial infarction
12. Apolipoproteins and coronary heart disease
13. Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men
14. Genetic epidemiology of common diseases in humans
15. ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels
16. Apolipoprotein E polymorphism and coronary artery disease
17. Use of DNA polymorphisms of the apolipoprotein genes to study the role of genetic variation in the determination of serum lipid levels
18. The use of measured genotype information in the analysis of quantitative phenotypes in man, II: The role of the apolipoprotein E polymorphism in determining levels, variability and covariability of cholesterol, betalipoprotein and triglycerides in a sample of unrelated individuals
19. Genetic architecture of inter-individual variability in apolipoprotein, lipoprotein and lipid phenotypes
20. The use of measured genotype information in the analysis of quantitative phenotypes in man, I: Models and analytical methods
21. Human pedigree-based quantitative-trait-locus mapping: Localization of two genes influencing HDL-cholesterol metabolism
22. A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11
23. A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans
24. A cholesterol-lowering gene maps to chromosome 13q
25. Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels
26. Total cholesterol and lipoproteins in school children: Prediction of coronary heart disease
27. Distribution of sodium-lithium countertransport and blood pressure in Caucasians five to eighty-nine years of age
28. An algorithm for automatic genotype elimination
29. Ped Check: A program for identification of genotype incompatibilities in linkage analysis
30. Improved method for determination of triglycerides in plasma lipoproteins by an enzymic kit method
31. Effects of polymorphisms in apolipoproteins E, A-IV, and H on quantitative traits related to risk for cardiovascular disease
32. Levels of lipids, lipoproteins, and apolipoproteins in a defined population
33. Comprehensive human genetic maps: Individual and sex-specific variation in recombination
34. A metric map of humans: 23,500 Loci in 850 bands
35. Multipoint quantitative-trait linkage analysis in general pedigrees
36. Multipoint interval mapping of quantitative trait loci, using sib pairs
37. Quantitative trait locus mapping using human pedigrees
38. Significance levels in complex inheritance
39. Statistical properties of a variance components method for quantitative trait linkage analysis in nuclear families and extended pedigrees
40. Apolipoprotein E and atherosclerosis: Insight from animal and human studies
41. Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations: The ECTIM Study
42. Association of apolipoprotein (Apo) E genotype with plasma apo E levels
43. Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation
44. Apolipoprotein E polymorphism in the Netherlands and its effect on plasma lipid and apolipoprotein levels
45. Apolipoprotein E variation at the sequence haplotype level: Implications for the origin and maintenance of a major human polymorphism
46. Power of linkage versus association analysis of quantitative traits, by use of variance-components models, for sibship data
47. Influences of common variants of apolipoprotein E on measures of lipid metabolism in a sample selected for health
48. An analysis of genotype effect and their interactions by using the apolipoprotein E polymorphism and longitudinal data
49. Association of apolipoprotein epsilon 4 allele with hypertriglyceridemia in obesity
50. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, Minnesota, II: Regression relationships with concomitants
51. The gender-specific apolipoprotein E genotype influence on the distribution of plasma lipids and apolipoproteins in the population of Rochester, MN, III: Correlations and covariances
52. Phenotype interaction of apobec-I and CETP, LDLR, and apoE gene expression in mice: Role of apoB mRNA editing in lipoprotein phenotype expression
53. Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity
54. Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: Potential genetic and phenotypic heterogeneity
55. Genetic studies on chromosome 12 in late-onset Alzheimer disease
56. Cholesterol efflux, lecithin-cholesterol acyltransferase activity and pre-β particle formation by serum from human apolipoprotein A-I and apolipoprotein A-I/apolipoprotein A-II transgenic mice consistent with the latter being less effective for reverse cholesterol transport
57. Carboxypeptidase E is a regulated secretory pathway sorting receptor: Genetic obliteration leads to endocrine disorders in Cpe (fat) mice
58. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
59. Hyperproinsulinemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
60. Fibrinogen genotype and risk of peripheral atherosclerosis
61. Long-term safety and efficacy of combination gemfibrozil and HMG-CoA reductase inhibitors for the treatment of mixed lipid disorders
62. Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARalpha activation
63. Bias of the contribution of single-locus effects to the variance of a quantitative trait
64. Genetic determination of HDL-C and apo-A1 plasma levels in a family study of cardiac catheterization patients
65. Segregation analysis of two-locus models regulating apolipoprotein-Al levels
66. Linkage and segregation analysis of apolipoproteins-A- I and B, and lipoprotein cholesterol levels in a large pedigree with excess coronary heart disease: The Bogalusa Heart Study
67. The inheritance of high density lipoprotein cholesterol and apolipoprotein A-I and A-II
68. Charting the fate of the "good cholesterol": Identification and characterization of the high density lipoprotein receptor SR-BI
69. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
70. Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia