Protein inhibitor of neuronal nitric oxide synthase (PIN) is a new regulator of glucose-induced insulin secretion

Diabetes

Volumn 55, Issue 12, 2006, Pages 3279-3288

  Lajoix, Anne Dominique ^a   Badiou, Stéphanie ^b   Péraldi Roux, Sylvie ^a   Chardès, Thierry ^a   Dietz, Samuel ^c   Aknin, Cindy ^d   Tribillac, Florence ^e   Petit, Pierre ^a   Gross, René ^a  

^a CNRS   (France)

^b MONTPELLIER UNIVERSITY HOSPITAL   (France)

^c INNODIA SAS   (France)

^d INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^e UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE METHYL ESTER; GLUCOSE; INSULIN; MICONAZOLE; MYOSIN VA; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PROTEIN INHIBITOR; PROTEIN INHIBITOR OF NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; IMMUNOFLUORESCENCE; INSULIN RELEASE; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CELL LINE; DYNEIN ATPASE; GLUCOSE; HOMEOSTASIS; INSULIN; ISLETS OF LANGERHANS; MYOSIN HEAVY CHAINS; MYOSIN TYPE V; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, WISTAR;

EID: 33845516309     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0257     Document Type: Article

References (43)

1. Moncada S, Palmer RM, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142, 1991
2. Bult H, Boeckxstaens GE, Pelckmans PA, Jordaens FH, Van Maercke YM, Herman AG: Nitric oxide as an inhibitory non-adrenergic non-cholinergic neurotransmitter. Nature 345:346-347, 1990
3. Palmer RM, Rees DD, Ashton DS, Moncada S: L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 153:1251-1256, 1988
4. Hibbs JB, Taintor RR, Vavrin Z, Rachlin EM: Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem Biophys Res Commun 157:87-94, 1988
5. Duncan AJ, Heales SJ: Nitric oxide and neurological disorders. Mol Aspects Med 26:67-96, 2005
6. Kolb H, Kolb-Bachofen V: Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator? Immunol Today 19:556-561, 1998
7. Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF: Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. Proc Natl Acad Sci U S A 97:14334-14339, 2000
8. Kleinert H, Pautz A, Linker K, Schwarz PM: Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol 500:255-266, 2004
9. Bredt DS, Snyder SH: Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A 87:682-685, 1990
10. Abu-Soud HM, Yoho LL, Stuehr DJ: Calmodulin controls neuronal nitricoxide synthase by a dual mechanism: activation of intra- and interdomain electron transfer. J Biol Chem 269:32047-32050, 1994
11. Bredt DS, Ferris CD, Snyder SH: Nitric oxide synthase regulatory sites: phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase: identification of flavin and calmodulin binding sites. J Biol Chem 267:10976-10981, 1992
12. Michell BJ, Chen ZP, Tiganis T, Stapleton D, Katsis F, Power DA, Sim AT, Kemp BE: Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 276:17625-17628, 2001
13. Venema VJ, Marrero MB, Venema RC: Bradykinin-stimulated protein tyrosine phosphorylation promotes endothelial nitric oxide synthase translocation to the cytoskeleton. Biochem Biophys Res Commun 226:703-710, 1996
14. Dedio J, Konig P, Wohlfart P, Schroeder C, Kummer W, Muller-Esterl W: NOSIP, a novel modulator of endothelial nitric oxide synthase activity. FASEB J 15:79-89, 2001
15. Feron O, Belhassen L, Kobzik L, Smith TW, Kelly RA, Michel T: Endothelial nitric oxide synthase targeting to caveolae: specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem 271:22810-22814, 1996
16. Jaffrey SR, Snyder SH: PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science 274:774-777, 1996
17. Dick T, Ray K, Salz HK, Chia W: Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster. Mol Cell Biol 16:1966-1977, 1996
18. Greenwood MT, Guo Y, Kumar U, Beausejours S, Hussain SN: Distribution of protein inhibitor of neuronal nitric oxide synthase in rat brain. Biochem Biophys Res Commun 238:617-621, 1997
19. Guo Y, Greenwood MT, Petrof BJ, Hussain SN: Expression and regulation of protein inhibitor of neuronal nitric oxide synthase in ventilatory muscles. Am J Respir Cell Mol Biol 20:319-326, 1999
20. Roczniak A, Levine DZ, Burns KD: Localization of protein inhibitor of neuronal nitric oxide synthase in rat kidney. Am J Physiol Renal Physiol 278:F702-F707, 2000
21. Benashski SE, Harrison A, Patel-King RS, King SM: Dimerization of the highly conserved light chain shared by dynein and myosin V. J Biol Chem 272:20929-20935, 1997
22. King SM, Barbarese E, Dillman JF, Patel-King RS, Carson JH, Pfister KK: Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. J Biol Chem 271:19358-19366, 1996
23. Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A: The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 3:287-296, 1999
24. Crepieux P, Kwon H, Leclerc N, Spencer W, Richard S, Lin R, Hiscott J: I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain. Mol Cell Biol 17:7375-7385, 1997
25. Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T: The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase. Genes Cells 5:905-911, 2000
26. Herzig RP, Andersson U, Scarpulla RC: Dynein light chain interacts with NRF-1 and EWG, structurally and functionally related transcription factors from humans and drosophila. J Cell Sci 113:4263-4273, 2000
27. Schnorrer F, Bohmann K, Nusslein-Volhard C: The molecular motor dynein is involved in targeting swallow and bicoid RNA to the anterior pole of Drosophila oocytes. Nat Cell Biol 2:185-190, 2000
28. Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz H, Kneussel M: Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. J Neurosci 22:5393-5402, 2002
29. Lajoix AD, Reggio H, Chardès T, Péraldi-Roux S, Tribillac F, Roye M, Dietz S, Broca C, Manteghetti M, Ribes G, Wollheim CB, Gross R: A neuronal isoform of nitric oxide synthase expressed in pancreatic β-cells controls insulin secretion. Diabetes 50:1311-1323, 2001
30. Lajoix AD, Pugnière M, Roquet F, Mani JC, Dietz S, Linck N, Faurie F, Ribes G, Petit P, Gross R: Changes in the dimeric state of neuronal nitric oxide synthase affect the kinetics of secretagogue-induced insulin response. Diabetes 53:1467-1474, 2004
31. Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB: Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130:167-178, 1992
32. Shibata A, Ludvigsen CW Jr, Naber SP, McDaniel ML, Lacy PE: Standardization of a digestion-filtration method for isolation of pancreatic islets. Diabetes 25:667-672, 1976
33. Herbert V, Lau KS, Gottlieb CW, Bleicher SJ: Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25:1375-1384, 1965
34. Varadi A, Tsuboi T, Rutter GA: Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells. Mol Biol Cell 16:2670-2680, 2005
35. Ivarsson R, Jing X, Waselle L, Regazzi R, Renstrom E: Myosin 5a controls insulin granule recruitment during late-phase secretion. Traffic 6:1027-1035, 2005
36. Beffy P, Lajoix AD, Masiello P, Dietz S, Péraldi-Roux S, Chardès T, Ribes G, Gross R: A constitutive nitric oxide synthase modulates insulin secretion in the INS-1 cell line. Mol Cell Endocrinol 183:41-48, 2001
37. Chang YW, Jakobi R, McGinty A, Foschi M, Dunn MJ, Sorokin A: Cyclooxygenase 2 promotes cell survival by stimulation of dynein light chain expression and inhibition of neuronal nitric oxide synthase activity. Mol Cell Biol 20:8571-8579, 2000
38. Rodriguez-Crespo I, Straub W, Gavilanes F, Ortiz de Montellano PR: Binding of dynein light chain (PIN) to neuronal nitric oxide synthase in the absence of inhibition. Arch Biochem Biophys 359:297-304, 1998
39. Pazour GJ, Wilkerson CG, Witman GB: A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT). J Cell Biol 141:979-992, 1998
40. Lo KW, Kan HM, Chan LN, Xu WG, Wang KP, Wu Z, Sheng M, Zhang M: The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation. J Biol Chem 280:8172-8179, 2005
41. Varadi A, Tsuboi T, Johnson-Cadwell LI, Allan VJ, Rutter GA: Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 beta-cells. Biochem Biophys Res Commun 311:272-282, 2003
42. Varadi A, Johnson-Cadwell LI, Cirulli V, Yoon Y, Allan VJ, Rutter GA: Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. J Cell Sci 117:4389-4400, 2004
43. Smith PA, Sakura H, Coles B, Gummerson N, Proks P, Ashcroft FM: Electrogenic arginine transport mediates stimulus-secretion coupling in mouse pancreatic beta-cells. J Physiol 499:625-635, 1997