Changes in the dimeric state of neuronal nitric oxide synthase affect the kinetics of secretagogue-induced insulin response

Diabetes

Volumn 53, Issue 6, 2004, Pages 1467-1474

  Lajoix, Anne Dominique ^a,b   Pugnière, Martine ^b   Roquet, Françoise ^b   Mani, Jean Claude ^b   Dietz, Samuel ^a,b   Linck, Nathalie ^b   Faurie, Fleur ^b   Ribes, Gérard ^b   Petit, Pierre ^b   Gross, René ^b,c  

^a INNODIA SAS   (France)

^b UMR 5160 CNRS   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

7 NITROINDAZOLE; BROPARESTROL; CYTOCHROME C; N(G) METHYLARGININE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DIMERIZATION; ENZYME ACTIVITY; INSULIN RELEASE; INSULIN RESPONSE; KINETICS; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; TEMPERATURE;

ANIMALS; ARGININE; CARRIER PROTEINS; CELL LINE; DIMERIZATION; DROSOPHILA PROTEINS; ENZYME INHIBITORS; GLUCOSE; INDAZOLES; INSULIN; KINETICS; MALE; MICONAZOLE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITROARGININE; NITROPRUSSIDE; RATS; RATS, WISTAR; SURFACE PLASMON RESONANCE;

EID: 2542611595     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.6.1467     Document Type: Article

References (38)

1. Moncada S, Palmer RM, Higgs EA: Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142, 1991
2. Ghosh DK, Abu-Soud HM, Stuehr DJ: Domains of macrophage NO synthase have divergent roles in forming and stabilizing the active dimeric enzyme. Biochemistry 35:1444-1449, 1996
3. Klatt P, Schmidt K, Uray G, Mayer B: Multiple catalytic functions of brain nitric oxide synthase: biochemical characterization, cofactor-requirement, and the role of N-omega-hydroxy-L-arginine as an intermediate. J Biol Chem 268:14781-14787, 1993
4. McCall TB, Feelisch M, Palmer RM, Moncada S: Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. Br J Pharmacol 102:234-238, 1991
5. Rees DD, Palmer RM, Schulz R, Hodson HF, Moncada S: Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101:746-752, 1990
6. Wolff DJ, Datto GA, Samatovicz RA, Tempsick RA: Calmodulin-dependent nitric-oxide synthase: mechanism of inhibition by imidazole and phenylimidazoles. J Biol Chem 268:9425-9429, 1993
7. Stuehr DJ, Fasehun OA, Kwon NS, Gross SS, Gonzalez JA, Levi R, Nathan CF: Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J 5:98-103, 1991
8. Cross AR, Jones OT: The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils: specific labelling of a component polypeptide of the oxidase. Biochem J 237:111-116, 1986
9. Klatt P, Schmid M, Leopold E, Schmidt K, Werner ER, Mayer B: The pteridine binding site of brain nitric oxide synthase: tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain. J Biol Chem 269:13861-13866, 1994
10. Schmidt HH, Warner TD, Ishii K, Sheng H, Murad F: Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science 255:721-723, 1992
11. Vincent SR: Nitric oxide and arginine-evoked insulin secretion. Science 258:1376-1378, 1992
12. Alm P, Ekstrom P, Henningsson R, Lundquist I: Morphological evidence for the existence of nitric oxide and carbon monoxide pathways in the rat islets of Langerhans: an immunocytochemical and confocal microscopical study. Diabetologia 42:978-986, 1999
13. Spinas GA, Laffranchi R, Francoys I, David I, Richter C, Reinecke M: The early phase of glucose-stimulated insulin secretion requires nitric oxide. Diabetologia 41:292-299, 1998
14. Lajoix AD, Reggio H, Chardes T, Peraldi-Roux S, Tribillac F, Roye M, Dietz S, Broca C, Manteghetti M, Ribes G, Wollheim CB, Gross R: A neuronal isoform of nitric oxide synthase expressed in pancreatic β-cells controls insulin secretion. Diabetes 50:1311-1323, 2001
15. Panagiotidis G, Alm P, Lundquist I: Inhibition of islet nitric oxide synthase increases arginine-induced insulin release. Eur J Pharmacol 229:277-278, 1992
16. Tsuura Y, Ishida H, Shinomura T, Nishimura M, Seino Y: Endogenous nitric oxide inhibits glucose-induced insulin secretion by suppression of phosphofructokinase activity in pancreatic islets. Biochem Biophys Res Commun 252:34-38, 1998
17. Gross R, Roye M, Manteghetti M, Hillaire-Buys D, Ribes G: Alterations of insulin response to different beta cell secretagogues and pancreatic vascular resistance induced by N omega-nitro-L-arginine methyl ester. Br J Pharmacol 116:1965-1972, 1995
18. 2+/ calmodulin-dependent cytochrome c reductase activity of brain nitric oxide synthase. J Biol Chem 267:11374-11378, 1992
19. Loubatières A, Mariani MM, Ribes G, de Malbosc H, Chapal J: Experimental study of a new especially active hypoglycemic sulfonamide, HB-419 or Glibenclamide. Diabetologia 5:1-10, 1969
20. Herbert V, Lau KS, Gotlieb CW, Bleicher SJ: Coated charcoal immunoassay of insulin. J Clin Endocrinol Metabol 25:1375-1384, 1965
21. Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB: Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130:167-178, 1992
22. Klatt P, Schmidt K, Lehner D, Glatter O, Bachinger HP, Mayer B: Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer. EMBO J 14:3687-3695, 1995
23. Beffy P, Lajoix AD, Masiello P, Dietz S, Péraldi-Roux S, Chardès T, Ribes G, Gross R: Constitutive NO synthase activity can modulate insulin secretion in the INS-1 cell line. Mol Cell Endocrinol 183:41-48, 2001
24. Klatt P, Pfeiffer S, List BM, Lehner D, Glatter O, Bachinger HP, Werner ER, Schmidt K, Mayer B: Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin. J Biol Chem 271: 7336-7342, 1996
25. Pfeiffer S, Leopold E, Schmidt K, Brunner F, Mayer B: Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol 118:1433-1440, 1996
26. Leiper J, Vallance P: Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovasc Res 43:542-548, 1999
27. Jaffrey SR, Snyder SH: PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Science 274:774-777, 1996
28. Lajoix AD, Dietz S, Péraldi-Roux S, Chardès T, Ribes G, Gross R: Protein inhibitor of a neuronal nitric oxide synthase is expressed in rat pancreatic β-cells and modulates insulin secretion (Abstract). Diabetologia 44 (Suppl. 1):A129, 2001
29. List BM, Klosch B, Volker C, Gorren AC, Sessa WC, Werner ER, Kukovetz WR, Schmidt K, Mayer B: Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization. Biochem J 323:159-165, 1997
30. Venema RC, Ju H, Zou R, Ryan JW, Venema VJ: Subunit interactions of endothelial nitric-oxide synthase: comparisons to the neuronal and inducible nitric-oxide synthase isoforms. J Biol Chem 272:1276-1282, 1997
31. Sennequier N, Stuehr DJ: Analysis of substrate-induced electronic, catalytic, and structural changes in inducible NO synthase. Biochemistry 35:5883-5892, 1996
32. Crane BR, Arvai AS, Ghosh DK, Wu C, Getzoff ED, Stuehr DJ, Tainer JA: Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science 279:2121-2126, 1998
33. Li H, Raman CS, Glaser CB, Blasko E, Young TA, Parkinson JF, Whitlow M, Poulos TL: Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase: implications for dimer stability and comparison with endothelial nitric-oxide synthase. J Biol Chem 274: 21276-21284, 1999
34. Raman CS, Li H, Martasek P, Kral V, Masters BS, Poulos TL: Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell 95:939-950, 1998
35. Dimmeler S, Lottspeich F, Brune B: Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem 267:16771-16774, 1992
36. Brown GC, Cooper CE: Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 356:295-298, 1994
37. Gross R, Roye M, Manteghetti M, Broca C, Hillaire-Buys D, Masiello P, Ribes G: Mechanisms involved in the effect of nitric oxide synthase inhibition on L-arginine-induced insulin secretion. Br J Pharmacol 120: 495-501, 1997
38. Abbasi F, Asagmi T, Cooke JP, Lamendola C, McLaughlin T, Reaven GM, Stuehlinger M, Tsao PS: Plasma concentrations of asymmetric dimethyl-arginine are increased in patients with type 2 diabetes. Am J Cardiol 88:201-1203, 2001