Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 12, 2006, Pages 4903-4910

  De Filippis, Elena ^a   Cusi, Kenneth ^b   Ocampo, Gloria ^b   Berria, Rachele ^c   Buck, Susan ^d   Consoli, Agostino ^e   Mandarino, Lawrence J ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d Texas Diabetes Institute   (United States)

^e UNIVERSITY OF CHIETI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM;

ADULT; AEROBIC CAPACITY; AEROBIC EXERCISE; ARTICLE; BRACHIAL ARTERY; CATHETERIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; FOREARM BLOOD FLOW; GLUCOSE METABOLISM; HUMAN; HYPEREMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; KINESIOTHERAPY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OXYGEN CONSUMPTION; PRIORITY JOURNAL; VASODILATATION;

EID: 33845488737     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-1142     Document Type: Article

References (43)

1. Dohm GL 2002 Exercise effects on muscle insulin signaling and action: invited review: regulation of skeletal muscle GLUT-4 expression by exercise. J Appl Physiol 93:782-787
2. Christ-Roberts CY, Mandarino LJ 2004 Glycogen synthase: key effect of exercise on insulin action. Exerc Sport Sci Rev 32:90-94
3. Brozinick Jr JT, Etgen Jr GJ, Yaspelkis 3rd BB, Ivy JL 1994 The effects of muscle contraction and insulin on glucose-transporter translocation in rat skeletal muscle. Biochem J 297:539-545
4. Brozinick Jr JT, Etgen Jr GJ, Yaspelkis 3rd BB, Kang HY, Ivy JL 1993 Effects of exercise training on muscle GLUT-4 protein content and translocation in obese Zucker rats. Am J Physiol Endocrinol Metab 265:E419-E427
5. Frosig C, Jorgensen SB, Hardie DG, Richter EA, Wojtaszewski JFP 2004 5′-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle. Am J Physiol Endocrinol Metab 286:E411-E417
6. Chen ZP, Stephens TJ, Murthy S, Canny BJ, Hargreaves M, Witters LA, Kemp BE, McConnel GK 2003 Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Diabetes 52:2205-2212
7. Nielsen JN, Mustard KJW, Graham DA, Yu H, MacDonald CS, Pilegaard H, Goodyear LJ, Hardie DG, Richter EA, Wojtaszewski JF 2003 5′-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle. J Appl Physiol 94:631-641
8. Clark SA, Chen ZP, Murphy KT, Aughey RJ, McKenna MJ, Kemp BE, Hawley JA 2004 Intensified exercise training does not alter AMPK signaling in human skeletal muscle. Am J Physiol Endocrinol Metab 286:E737-743
9. Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Kashyap S, Mandarino LJ 2004 Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects. Metabolism 53:1233-1242
10. Tanner CJ, Koves TR, Cortright RL, Pories WJ, Kim YB, Kahn BB, Dohn GL, Houmard JA 2002 Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men. Am J Physiol Endocrinol Metab 282:E147-E153
11. Caballero AE 2005 Metabolic and vascular abnormalities in subjects at risk for type 2 diabetes: the early start of a dangerous situation. Arch Med Res 36: 241-249
12. Caballero AE 2003 Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease. Obes Res 11:1278-1289
13. Haffner SM 2003 Pre-diabetes, insulin resistance, inflammation and CVD risk. Diabetes Res Clin Pract 61:S9-S18
14. Caballero A, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, King GL, LoGerfo FW, Horton ES, Veves A 1999 Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes 48:1856-1862
15. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD 1996 Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 97:2601-2610
16. Williams SB, Cusco JA, Roddy MA, Johnstone MT, Creager MA 1996 Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 27:567-574
17. Baron A 1996 Insulin and vasculature: old actors, new roles. J Invest Med 44:406-412
18. Davignon J, Ganz P 2004 Role of endothelial dysfunction in atherosclerosis. Circulation 109 (Suppl 1):III27-III33
19. Landmesser U, Homig B, Drexler H 2004 Endothelial function: a critical determinant in atherosclerosis? Circulation 109(Suppl 1):II27-II33
20. Green DJ, Maiorana A, O'Driscoll G, Taylor R 2004 Effect of exercise training on endothelium-derived nitric oxide function in humans. J Physiol (Lond) 561:1-25
21. Walsh JH, Bilsborough W, Maiorana A, Best M, O'Driscoll GJ, Taylor RR, Green DJ 2003 Exercise training improves conduit vessel function in patients with coronary artery disease. J Appl Physiol 95:20-25
22. Hakim AA, Curb JD, Petrovitch H, Rodriquez BL, Yano K, Ross GW, White LR, Abbott RD 1999 Effects of walking on coronary heart disease in elderly men: the Honolulu Heart Program. Circulation 100:9-13
23. Sesso HD, Paffenbarger Jr RS, Lee IM 2000 Physical activity and coronary heart disease in men: the Harvard Alumni Health Study. Circulation 102:975-980
24. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE 2002 Exercise capacity and mortality among men referred for exercise testing. N Engl J Med 346:793-801
25. Jolliffe JA, Rees K, Taylor RS, Thompson D, Oldridge N, Ebrahim S 2001 Exercise-based rehabilitation for coronary heart disease. Cochrane Database Syst Rev 1:CD001800
26. Maiorana A, O'Driscoll G, Cheetham C, Demdo C, Stanton K, Goodman C, Taylor R, Green D 2001 The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol 38:860-866
27. Taylor JA, Hand G, Johnson DG, Seals DR 1992 Augmented forearm vasoconstriction during dynamic exercise in healthy older men. Circulation 86:1789-1799
28. Brozek JGF, Anderson JT 1962 Densitometric analysis of body composition: revision of some quantitative assumptions. Ann NY Acad Sci 110:113-140
29. Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ 2000 Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest 105:311-320
30. DeFronzo RA, Tobin JD, Reubin A 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 6:E214-E223
31. Higashi Y, Yoshizumi M 2003 New methods to evaluate endothelial function: method for assesing endothelial function in humans using a strain-gauge plethysmography: nitric oxide-dependent and -independent vasodilation. J Pharmacol Sci 2003:399-404
32. McVeigh GE, Brennan GM, Johnston GD, McDermott BJ, McGrath LT, Henry WR, Andrews JW, Hayes JR 1992 Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 35:771-776
33. Higashi Y, Sasaki S, Nakagawa K, Kimura M, Nona K, Sasaki S, Hara K, Matsuura H, Goto C, Oshima T Chayamo K, Yoshizumi M 2003 Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress. J Am Coll Cardiol 42:256-263
34. Taddei S, Virdis A, Mattei P, Ghiadoni L, Fasolo CB, Sudano I, Salvetti A 1997 Hypertension causes premature aging of endothelial function in humans. Hypertension 29:736-743
35. Hambrecht R, Adams V, Erbs S, Linke A, Krankel N, Shu Y, Baither Y, Gielsen S, Thiele H, Gumert JF, Mohr FW, Schuler G 2003 Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 107:3152-3158
36. Kingwell BA, Sherrard B, Jennings GL, Dart AM 1997 Four weeks of cycle training increases basal production of nitric oxide from the forearm. Am J Physiol Heart Circ Physiol 272:H1070-H1077
37. Green DJ, Walsh JH, Maiorana A, Burke V, Taylor RR, O'Driscoll JG 2004 Comparison of resistance and conduit vessel nitric oxide-mediated vascular function in vivo: effects of exercise training. J Appl Physiol 97:749-755
38. Fisslthaler B, Dimmeler S, Hermann C, Busse R, Fleming I 2000 Phosphorylation and activation of the endothelial nitric oxide synthase by fluid shear stress. Acta Physiol Scand 168:81-88
39. Malek AM, Izumo S, Alper SL 1999 Modulation by pathophysiological stimuli of the shear stress-induced up-regulation of endothelial nitric oxide synthase expression in endothelial cells. Neurosurgery 45:334-345
40. Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH 1994 Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res 74:349-353
41. Johnson LR, Rush JWE, Turk JR, Price EM, Laughlin MH 2001 Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries. J Appl Physiol 90:1102-1110
42. Laughlin MH, Pollock JS, Amann JF, Hollis ML, Woodman CR, Price EM 2001 Training induces nonuniform increases in eNOS content along the coronary arterial tree. J Appl Physiol 90:501-510
43. Thompson PD, Crouse S, Goodpaster B, Kelley D, Moyna N, Pescatello L 2001 The acute versus the chronic response to exercise. Med Sci Sports Exerc 33:S438-S445