Experimental evidence for early nutritional programming of later health in animals

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 9, Issue 3, 2006, Pages 278-283

  Symonds, Michael E ^a,b   Gardner, David S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Adipose tissue; Glucocorticoids; Lactation; Nutrition; Pregnancy

Indexed keywords

ADIPOSE TISSUE; EPIGENETICS; FOOD INTAKE; LACTATION; MATERNAL NUTRITION; METABOLIC DISORDER; NONHUMAN; NUTRITION; NUTRITIONAL DEFICIENCY; PERINATAL PERIOD; PREGNANCY; PROTEIN DIET; PROTEIN EXPRESSION; REVIEW; RISK ASSESSMENT;

ADULT; ANIMALS; BIRTH WEIGHT; CARDIOVASCULAR DISEASES; CHILD; CHILD NUTRITION PHYSIOLOGY; CHILD, PRESCHOOL; CHRONIC DISEASE; FEMALE; HUMANS; INFANT; INFANT NUTRITION PHYSIOLOGY; INFANT, NEWBORN; MALE; MATERNAL NUTRITION PHYSIOLOGY; OBESITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PRENATAL NUTRITION PHYSIOLOGY; SEX FACTORS;

ANIMALIA;

EID: 33746253814     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/01.mco.0000222112.46042.19     Document Type: Review

References (47)

1. Department of Health. Choosing Health: making healthier choices easier (Public Health White Paper). London: HMSO; 2004.
2. Budge H, Gnanalingham MG, Gardner DS, et al. Maternal nutritional programming of fetal adipose tissue development: long term consequences for later obesity. Birth Defects Res C Embryo Today 2005; 75:193-199. Up-to-date review of the impact of diet in pregnancy and later offspring obesity.
3. Gross LS, Li L, Ford ES, et al. Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment. Am J Clin Nutr 2004; 79:774-779.
4. Barker DJP. In utero programming of chronic disease. Clin Sci 1998; 95:115-128.
5. Barker DJP. The malnourished baby and infant. Br Med Bull 2001; 60:69-88.
6. Gillman M. Developmental origins of health and disease. N Engl J Med 2005; 353:1848-1850. Summarizes current clinical views with regard to the impact of epidemiological findings on later adult disease.
7. Barker D, Osmond C, Forsén T, et al. Trajectories of growth among children who have coronary events as adults. N Engl J Med 2005; 353:1802-1809. Emphasizes the importance of changes in growth through childhood with respect to increased risk of later disease.
8. McMillen IC, Robinson JS. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Phys Rev 2005; 85:571-633. Comprehensive and state-of-the-art review of current concepts of fetal programming.
9. Armitage JA, Khan IY, Taylor PD, et al. Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J Physiol 2004; 561:355-377. Excellent summary focusing on the different small-animal models of nutritional programming.
10. Roseboom TJ, van der Meulen JHP, Osmond C, et al. Coronary heart disease in adults after perinatal exposure to famine. Heart 2000; 84:595-598.
11. Vickers MH, Ikenasio BA, Breier BH. IGF-I treatment reduces hyperphagia, obesity, and hypertension in metabolic disorders induced by fetal programming. Endocrinology 2001; 142:3964-3973.
12. Bloomfield FH, Oliver MH, Hawkins P, et al. A periconceptional nutritional origin for noninfectious preterm birth. Science 2001; 300:606.
13. Woods LL, Ingelfinger JR, Rasch R. Modest maternal protein restriction fails to program adult hypertension in female rats. Am J Physiol Regul Integr Comp Physiol 2005; 289:R1131-R1136. The results of this study indicate that maternal consumption of a LPD does not always produce hypertensive offspring.
14. McMullen S, Langley-Evans SC. Maternal low protein diet in rat pregnancy programmes blood pressure through sex-specific mechanisms. Am J Physiol Regul lntegr Comp Physiol 2005; 288:R85-R90. Interesting paper showing that the short-term blood pressure outcomes of nutrient deprivation during pregnancy may be mediated by maternally derived corticosteroids.
15. Joshi S, Rao S, Golwilkar A, et al. Fish oil supplementation of rats during pregnancy reduces adult disease risks in their offspring. J Nutr 2003; 133:3170-3174.
16. Kwong WY, Wild AE, Roberts P, et al. Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and prog ramming of postnatal hypertension. Development 2000; 127:4195-4202.
17. Woods LL, Weeks DA. Prenatal programming of adult blood pressure: role of maternal corticosteroids. Am J Physiol Regul lntegr Comp Physiol 2005; 289:R955-R962. Demonstrates that the programming effects of maternal dexamethasone administration are mediated in part through changes in maternal food intake.
18. Wainwright PE. Issues of design and analysis relating to the use of multiparous species in developmental nutritional studies. J Nutr 1998; 128:661-663.
19. Gardner DS, Pearce S, Dandrea J, et al. Peri-implantation undernutrition programs blunted angiotensin II evoked baroreflex responses in young adult sheep. Hypertension 2004; 43:1-7.
20. Ookuwa H, Takata S, Ogawa J, et al. Abnormal cardiopulmonary baroreflexes in normotensive young subjects with a family history of essential hypertension. J Clin Hypertens 1987; 3:596-604.
21. Eckberg DL. Carotid baroreflex function in young men with borderline blood pressure elevation. Circulation 1979; 59:632-636.
22. Khan IY, Taylor PD, Dekou V, et al. Gender-linked hypertension in offspring of lard fed pregnant rats. Hypertension 2003; 188:454-460.
23. Wyrwoll CS, Mark PJ, Mori TA, et al. Prevention of programmed hyperleptinemia and hypertension by postnatal dietary omega-3 fatty acids. Endocrinology 2006; 147:599-606. This paper demonstrates the potential of nutritional manipulation during lactation for reversing the adverse long-term programming outcomes that can accompany maternal dexamethasone administration.
24. Khan I, Dekou V, Hanson M, et al. Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation 2004; 110:1097-1102.
25. Daenzer M, Ortmann S, Klaus S, et al. Prenatal high protein exposure decreases energy expenditure and increases adiposity in young rats. J Nutr 2002; 132:142-144.
26. Budge H, Bispham J, Dandrea J, et al. Effect of maternal nutrition on brown adipose tissue and prolactin receptor status in the fetal lamb. Pediatr Res 2000; 47:781-786.
27. Budge H, Dandrea J, Mostyn A, et al. Differential effects of fetal number and maternal nutrition in late gestation on prolactin receptor abundance and adipose tissue development in the neonatal lamb. Pediatr Res 2003; 53:302-308.
28. Bispham J, Gopalakrishnan GS, Dandrea J, et al. Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development. Endocrinology 2003; 144:3575-3585.
29. Wallace JM, Milne JS, Aitken RP. The effect of overnourishing singleton-bearing adult ewes on nutrient partitioning to the gravid uterus. Br J Nutr 2005; 94:533-539. Demonstrates that maternal overnutrition does not necessarily equate with excess nutrient supply to the fetus.
30. Gopalakrishnan G, Gardner DS, Dandrea J, et al. Influence of maternal pre-pregnancy body composition and diet during early-mid pregnancy on cardiovascular function and nephron number in juvenile sheep. Br J Nutr 2005; 94:938-947. Indicates that maternal nutrient restriction can result in offspring with lower blood pressure despite fewer nephrons in their kidney.
31. Gnanalingham MG, Mostyn A, Symonds ME, et al. Ontogeny and nutritional programming of fat mass: potential role of glucocorticoid sensitivity and uncoupling protein-2. Am J Physiol Regul Integr Comp Physiol 2005; 289:R1407-R1415. Demonstrates the close relationship between adipocyte sensitivity to corticosteroids and the increase in fat mass with age.
32. Bispham J, Gardner DS, Gnanalingham MG, et al. Maternal nutritional programming of fetal adipose tissue development: differential effects on mRNA abundance for uncoupling proteins, peroxisome proliferator activated and prolactin receptors. Endocrinology 2005; 146:3943-3949. Indicates the differential effects of manipulating maternal diet through pregnancy and subsequent effects on fat mass and sensitivity.
33. Ziegler EE, O'Donnell AM, Nelson SE, et al. Body composition of the reference fetus. Growth 1976; 40:329-341.
34. Zhang CY, Baffy G, Perret P, et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 2001; 105:745-755.
35. Dandrea J, Wilson V, Gopalakrishnan G, et al. Maternal nutritional manipulation of placental growth and glucose transporter 1 (GLUT-1) abundance in sheep. Reproduction 2001; 122:793-800.
36. Boullu-Ciocca S, Dutour A, Guillaume V, et al. Postnatal diet-induced obesity in rats upregulates systemic and adipose tissue glucocorticoid metabolism during development and in adulthood. Diabetologia 2005; 54:197-203. Emphasizes the importance of postnatal nutrition and adipocyte development with respect to their sensitivity to corticosteroids.
37. Grino M. Prenatal nutritional programming of central obesity and the metabolic syndrome: role of adipose tissue glucocorticoid metabolism. Am J Physiol Regul Integr Comp Physiol 2005; 289:R1233-R1235. Summarizes the role of adipocyte sensitivity to corticosteroids in later obesity.
38. Whorwood CB, Firth KM, Budge H, et al. Maternal undernutrition during early-to mid-gestation programmes tissue-specific alterations in the expression of the glucocorticoid receptor, 11β-hydroxysteroid dehydrogenase isoforms and type 1 angiotensin II receptor in neonatal sheep. Endocrinology 2001; 142:2854-2864.
39. Woods LL, Ingelfinger JR, Nyengaard JR, et al. Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats. Pediatr Res 2001; 49:460-467.
40. Weaver IC, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004; 847-854.
41. Lillycrop KA, Phillips ES, Jackson AA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005; 135:1382-1386. First study showing that large changes in maternal folic acid consumption throughout pregnancy and lactation can affect the DNA methylation of some hepatic genes in the offspring.
42. Devlin AM, Bottiglieri T, Domann FE, et al. Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J Biol Chem 2005; 280:25506-25511. Important study indicating what can happen with severe folic acid deficiency.
43. Ozanne SE, Hales CN. Lifespan: catch-up growth and obesity in male mice. Nature 2004; 427:411-412.
44. Vickers MH, Gluckman PD, Coveny AH, et al. Neonatal leptin treatment reverses developmental programming. Endocrinology 2005; 146:4211-4216. Demonstrates the potential for reversing the adverse long-term programming outcomes that can accompany intra-uterine growth retardation.
45. Gnanalingham MG, Mostyn A, Webb R, et al. Differential effects of leptin administration on the abundance of uncoupling protein-2 and glucocorticoid action during neonatal development. Am J Physiol Endocrinol Metab 2005; 289:E1093-E1100. Indicates that leptin in the neonate can increase tissue sensitivity to corticosteroids.
46. Gnanalingham MG, Mostyn A, Gardner DS, et al. Developmental regulation of adipose tissue: nutritional manipulation of local glucocorticoid action and uncoupling protein 2. Adipocytes 2005; 1 (in press). Comprehensive review of the impact of maternal diet on fetal and later adiposity.
47. Gnanalingham MG, Mostyn A, Gardner DS, et al. Developmental regulation of the lung in preparation for life after birth: nutritional manipulation of local glucocorticoid action and uncoupling protein 2. J Endocrinol 2006; (in press). Comprehensive review of the impact of maternal diet on fetal and later lung development.