The dose makes the medicine

Drug Discovery Today

Volumn 11, Issue 11-12, 2006, Pages 550-555

  Stumpf, Walter E ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CARDIAC GLYCOSIDE; CONJUGATED ESTROGEN; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; DIGITOXIN; ESTRADIOL; MEDROXYPROGESTERONE ACETATE; VITAMIN D;

CELL POPULATION; DOSE CALCULATION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EXCRETION; DRUG MEGADOSE; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG TARGETING; EPIDERMIS CELL; HIGH THROUGHPUT SCREENING; HORMESIS; KERATINOCYTE; LOW DRUG DOSE; REVIEW; VALIDATION STUDY;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; PHARMACEUTICAL PREPARATIONS; SYSTEMS BIOLOGY; VITAMIN D;

EID: 33646501518     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2006.04.012     Document Type: Review

References (32)

1. Rozman K.K., and Doull J. Dose and time as variables of toxicity. Toxicology 144 (2000) 169-178
2. Stumpf W.E. Corpora non agunt nisi in loco. Drug Metab. Dispos. 24 (1996) 507-508
3. Stumpf W.E. Drug Localization in Tissues and Cells (2003), IDDC-Press, Chapel Hill, NC
4. Poerksen G. Paracelsus. Septem Defensiones. Die Selbstverteidigung eines Aussenseiters (2003), Schwabe
5. Kluge F. Etymologisches Wörterbuch der deutschen Sprache (1999), Walter de Gruyter-Verlag
6. Stumpf W.E. In: Bettendorf G. (Ed). Zur Geschichte der Endokrinologie und Reproduktionsmedizin (1995), Springer Verlag 573
7. Stumpf W.E. Drug localization and targeting with receptor microscopic autoradiography. J. Pharmacol. Toxicol. Methods 51 (2005) 25-40
8. Drews J. Drug discovery: a historical perspective. Science 287 (2000) 1960-1964
9. Betz U.A. How many genomic targets can a portfolio afford?. Drug Discov. Today 10 (2005) 1057-1063
10. Hesiod (1914) (Translated by H.G. Evelyn-White) Works and Days. Perseus Digital Library
11. Doull J. Toxicology comes of age. Annu. Rev. Pharmacol. Toxicol. 41 (2001) 1-21
12. Schulz H. Zur Lehre von der Arzneiwirkung. [Virchows] Archiv fuer pathologische Anatomie und Physiologie und fuer klinische Medizin 108 (1887) 423-445
13. Hoffmann K.F. The pharmacologist Hugo Schulz, 1853-1932. Med. Monatsschr. 11 (1957) 607-609
14. Calabrese, E.J. and Baldwin, L.A. Chemical hormesis: its historical foundations as a biological hypothesis. Toxicol. Path. 27, 195-216
15. Rozman K.K., and Doull J. Paracelsus, Haber and Arndt. Toxicology 160 (2001) 191-196
16. Monro A.M. Are routine tissue distribution studies justifiable for approval of human drugs?. Drug Metab. Dispos. 22 (1994) 341-342
17. Holderegger C., et al. Quantitative autoradiographic analysis of in situ estrogen concentration by individual cell types of mouse target organs: dose-uptake study. Biol. Reprod. 25 (1981) 719-724
18. Hayakawa N., et al. Receptor microscopic autoradiography for the study of percutaneous absorption, in vivo skin penetration, and cellular-intercellular deposition. J. Pharmacol. Toxicol. Methods 50 (2004) 131-137
19. 3 in intestinal tract, stomach, kidney, skin, pituitary and parathyroid. Science 206 (1979) 1188-1190
20. 3: a novel agent for enhancing wound healing. J. Cell. Biochem. 59 (1995) 53-56
21. Kragballe K. Vitamin D analogues in the treatment of psoriasis. J. Cell. Biochem. 49 (1992) 46-52
22. Heraclit (2001) (Translated by Brooks Haxton) Fragments: The collected wisdom of Heraclitus. Viking Penguin
23. Calabrese E.J., and Baldwin L.A. Hormesis: a generalizable and unifying hypothesis. Crit. Rev. Toxicol. 31 (2001) 353-424
24. Garner R.C. Less is more: the human microdosing concept. Drug Discov. Today 10 (2005) 449-451
25. Wilding I.R., and Bell J.A. Improved early clinical development through human microdosing studies. Drug Discov. Today 10 (2005) 890-894
26. Davidov E., et al. Advancing drug discovery through systems biology. Drug Discov. Today 8 (2003) 175-183
27. Carney S. How can we avoid the productivity gap?. Drug Discov. Today 10 (2005) 1011-1013
28. Stumpf W.E. Vitamin D sites and mechanisms of action. A histochemical perspective. Reflections on the utility of autoradiography and cytopharmacology for drug targeting. Histochem. Cell Biol. 104 (1995) 417-427
29. Boulnois G.J. Drug discovery in the new millennium: the pivotal role of biotechnology. Trends Biotechnol. 18 (2000) 31-33
30. Almog D.M. Drug industry in "depression". Med. Sci. Monit. 11 (2005) SR1-SR4
31. Salomone L., and Santen R.J. Bioidentical hormone replacement: myths and facts. Endocrine News (2005 July) 8-11
32. Stumpf W.E., et al. The heart: A target organ for estradiol. Science 196 (1977) 319-321