Pseudomonas aeruginosa quorum sensing molecule N-(3 oxododecanoyl)-l-homoserine lactone disrupts epithelial barrier integrity of Caco-2 cells

FEBS Letters

Volumn 580, Issue 30, 2006, Pages 6921-6928

  Vikström, Elena ^a   Tafazoli, Farideh ^a   Magnusson, Karl Eric ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Cytoskeleton; Epithelial barrier; MAPK; Pseudomonas aeruginosa; Quorum sensing; Tight junction

Indexed keywords

N (3 OXODODECANOYL)HOMOSERINE LACTONE; OCCLUDIN; PROTEIN ZO1;

ARTICLE; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; VIRULENCE;

4-BUTYROLACTONE; ACTINS; CACO-2 CELLS; CELL ADHESION; CELL PROLIFERATION; DEXTRANS; ELECTRIC IMPEDANCE; ENZYME ACTIVATION; EPITHELIAL CELLS; HOMOSERINE; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, SCANNING; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; PROTEIN KINASE INHIBITORS; PSEUDOMONAS AERUGINOSA; QUORUM SENSING;

PSEUDOMONAS AERUGINOSA;

EID: 33845427659     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.11.057     Document Type: Article

References (34)

1. Miyoshi J., and Takai Y. Molecular perspective on tight-junction assembly and epithelial polarity. Adv. Drug. Deliv. Rev. 57 (2005) 815-855
2. Clayburgh D.R., Shen L., and Turner J.R. A porous defense: the leaky epithelial barrier in intestinal disease. Lab. Invest. 84 (2004) 282-291
3. Van Itallie M.C., and Anderson J.M. The molecular physiology of tight junction pores. Physiology 19 (2004) 331-338
4. Pearson G., Robinson F., Gibson T.B., Xu B.E., Karandikar M., Berman K., and Cobb M.H. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22 (2001) 153-183
5. Matter K., and Balda M.S. Signaling to and from tight junctions. Nat. Rev. Mol. Cell. Biol. 4 (2003) 225-236
6. Williams P., Camara M., Hardman A., Swift S., Milton D., Hope V.J., Winzer K., Middleton B., Pritchard D.I., and Bycroft B.W. Quorum sensing and the population-dependent control of virulence. Phil. Trans. R. Soc. Lond. B: Biol. Sci. 355 (2000) 667-680
7. Henke J.M., and Bassler B.L. Bacterial social engagements. Trends Cell Biol. 14 (2004) 648-656
8. Smith R.S., and Iglewski B.H. P. aeruginosa quorum-sensing systems and virulence. Curr. Opin. Microbiol. 6 (2003) 56-60
9. Juhas M., Eberl L., and Tummler B. Quorum sensing: the power of cooperation in the world of Pseudomonas. Environ. Microbiol. 7 (2005) 459-471
10. Chhabra S., Harty C., Hooi D., Daykin M., Telford G., Pritchard D., and Bycroft B. Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-l-homoserine lactone as immune modulators. J. Med. Chem. 46 (2003) 97-104
11. Telford G., Wheeler D., Williams P., Tomkins P.T., Appleby P., Sewell H., Stewart G.S., Bycroft B.W., and Pritchard D.I. The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-l-homoserine lactone has immunomodulatory activity. Infect. Immun. 66 (1998) 36-42
12. 2 production in human lung fibroblasts: implications for inflammation. J. Immunol. 169 (2002) 2636-2642
13. Smith R.S., Fedyk E.R., Springer T.A., Mukaida N., Iglewski B.H., and Phipps R.P. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-κB and activator protein-2. J. Immunol. 167 (2001) 366-374
14. Surette M.G., and Bassler B.L. Quorum sensing in Escherichia coli and Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 95 (1998) 7046-7050
15. Sakurazawa T., and Ohkusa T. Cytotoxicity of organic acids produced by anaerobic intestinal bacteria on cultured epithelial cells. J. Gastroenterol. 40 (2005) 600-609
16. Winson M.K., Swift S., Fish L., Throup J.P., Jørgensen F., Chhabra S.R., Bycroft B.W., Williams P., and Stewart G.S.A.B. Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing. FEMS Microbiol. Lett. 163 (1998) 185-192
17. Wu L.R., Zaborina O., Zaborin A., Chang E.B., Musch M., Holbrook C., Turner J.R., and Alverdy J.C. Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa. Surg. Infect. 6 (2005) 185-195
18. Wu L., Holbrook C., Zaborina O., Ploplys E., Rocha F., Pelham D., Chang E., Musch M., and Alverdy J. Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the quorum sensing system. Ann. Surg. 238 (2003) 754-764
19. Erickson D.L., Endersby R., Kirkham A., Stuber K., Vollman D., Rabin H.R., Mitchell I., and Storey D.G. Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis. Infect. Immun. 70 (2002) 1783-1790
20. Charlton T.S., de Nys R., Netting A., Kumar N., Hentzer M., Givskov M., and Kjelleberg S. A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry: application to a model bacterial biofilm. Environ. Microbiol. 2 (2000) 530-541
21. Hirakata Y., Izumikawa K., Yamaguchi T., Igimi S., Furuya N., Maesaki S., Tomono K., Yamada Y., Kohno S., Yamaguchi K., and Kamihira S. Adherence to and penetration of human intestinal Caco-2 epithelial cell monolayers by Pseudomonas aeruginosa. Infect. Immun. 66 (1998) 1748-1751
22. Mashburn L.M., and Whiteley M. Membrane vesicles traffic signals and facilitate group activities in a prokaryote. Nature 437 (2005) 422-425
23. Laughlin R.S., Musch M.W., Hollbrook C.J., Rosha F.M., Chang E.B., and Alverdy J.C. The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis. Ann. Surg. 232 (2000) 133-142
24. Yi X., Wang Y., and Yu F.S. Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. Invest. Ophthalmol. Vis. Sci. 41 (2000) 4093-40100
25. Chun C.K., Ozer E.A., Welsh M.J., Zabner J., and Greenberg E.P. Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia. Proc. Natl. Acad. Sci. USA 101 (2004) 3587-3590
26. Dong Y.H., Wang L.H., Xu J.L., Zhang H.B., Zhang X.F., and Zhang L.H. Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature 411 (2001) 813-817
27. Lin Y.H., Xu J.L., Hu J., Wang L.H., Ong S.L., Leadbetter J.R., and Zhang L.H. Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes. Mol. Microbiol. 47 (2003) 849-860
28. Manefield M., de Nys R., Kumar N., Read R., Givskov M., Steinberg P., and Kjelleberg S. Evidence that halogenated furanones from Delisea pulchra inhibit acylated homoserine lactone (AHL)-mediated gene expression by displacing the AHL signal from its receptor protein. Microbiology 145 (1999) 283-291
29. Teplitski M., Robinson J.B., and Bauer W.D. Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria. Mol. Plant Microbe Interact. 13 (2000) 637-648
30. Vikström E., Magnusson K.E., and Pivoriunas A. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone stimulates phagocytic activity in human macrophages through the p38 MAPK pathway. Microbes Infect. 7 (2005) 1512-1518
31. Clark A.R., Dean J.L., and Saklatvala J. Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. FEBS Lett. 546 (2003) 37-44
32. Liu W.Y., Lee W.M., and Cheng C.Y. Transforming growth factor β3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway. Biol. Reprod. 68 (2003) 1597-1612
33. Lan M., Kojima T., Osanai M., Chiba H., and Sawada N. Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line. Carcinogenesis 25 (2004) 2385-2395
34. Kevil C.G., Oshima T., and Alexander J.S. The role of p38 MAP kinase in hydrogen peroxide mediated endothelial solute permeability. Endothelium 8 (2001) 107-116