The 5-HTTLPR s/s genotype at the serotonin transporter gene (SLC6A4) increases the risk for depression in a large cohort of primary care attendees: The PREDICT-gene study

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 141, Issue 8, 2006, Pages 912-917

  Cervilla, Jorge A ^a,b   Rivera, Margarita ^a   Molina, Esther ^a   Torres González, Francisco ^a   Bellón, Juan A ^c   Moreno, Berta ^a,d   De Dios Luna, Juan ^b   Lorente, José A ^a   De Diego Otero, Yolanda ^d   King, Michael ^e   Nazareth, Irwin ^f   Gutiérrez, Blanca ^a,b  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c UNIVERSITY OF MÁLAGA   (Spain)

^d Hospital University Carlos Haya de Málaga   (Spain)

^e ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

5 HTTLPR; Association; Depression; Generalized anxiety; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; AGE; AGED; ANXIETY DISORDER; ARTICLE; COHORT ANALYSIS; COMORBIDITY; COMPOSITE INTERNATIONAL DIAGNOSTIC INTERVIEW; CONTROLLED STUDY; DEPRESSION; DIAGNOSTIC PROCEDURE; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE SEVERITY; FAMILY HISTORY; FEMALE; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE PHENOTYPE CORRELATION; HOMOZYGOSITY; HUMAN; INTERNATIONAL CLASSIFICATION OF DISEASES; INTERNATIONAL CLASSIFICATION OF DISEASES 10; INTERVIEW; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; PSYCHOLOGICAL ASPECT; RISK FACTOR; SEROTONIN TRANSPORTER GENE; SEX DIFFERENCE; SPAIN; UNIVARIATE ANALYSIS;

ADULT; AGED; DEPRESSION; DNA PRIMERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MODELS, GENETIC; ODDS RATIO; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPAIN;

EID: 33845410256     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30455     Document Type: Article

References (33)

1. Anguelova M, Benkelfat C, Turecki G. 2003. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry 8:574-591.
2. Arias B, Catalan R, Gasto C, Gutierrez B, Fananas L. 2003. 5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients treated with citalopram in a 12-weeks follow up study. J Clin Psychopharmacol 23:563-567.
3. Bellivier F, et al. 1998. Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression. Neurosci Lett 255:143-146.
4. Brugha TS, Jenkins R, Taub N, Meltzer H, Bebbington PE. 2001. A general population comparison of the Composite International Diagnostic Interview (CIDI) and the Schedules for Clinical Assessment in Neuropsychiatry (SCAN). Psychol Med 31:1001-1013.
5. Caspi A, et al. 2003. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301:386-389.
6. Collier DA, et al. 1996. A novel functional polymorphism within the promoter of the serotonin transporter gene: Possible role in susceptibility to affective disorders. Mol Psychiatry 1:453-460.
7. Diez-Quevedo C, Rangil T, Sanchez-Planell L, Kroenke K, Spitzer RL. 2001. Validation and utility of the patient health questionnaire in diagnosing mental disorders in 1003 general hospital Spanish inpatients. Psychosom Med 63:679-686.
8. Furlong RA, et al. 1998. Analysis and meta-analysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am J Med Genet 81:58-63.
9. Goldberg D, Huxley P. 1992. Common mental disorders a biosocial model. London: Routledge.
10. Gutierrez B, et al. 1998. Variability in the serotonin transporter gene and increased risk for major depression with melancholia. Hum Genet 103:319-322.
11. Hariri AR, et al. 2005. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 62:146-152.
12. Hoefgen B, et al. 2005. The power of sample size and homogenous sampling: Association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Biol Psychiatry 57:247-251.
13. Hu XZ, Zhu GS, Lipsky RH, Goldman D. 2004. HTTLPR allele expression is codominant, correlating with gene effects on fMRI and SPECT imaging intermediate phenotypes, and behavior. Biol Psychiatry 55:1918.
14. Jones I. 2004. Genetics of affective disorder in psychiatric genetics and genomics, In: McGuffin P, editor. London: Cambridge University Press. pp 223-224.
15. King M, et al. 2006. Prediction of depression in European general practice attendees: The PREDICT study. BMC Public Health 6:6.
16. Kunugi H, et al. 1997. Serotonin transporter gene polymorphisms: Ethnic difference and possible association with bipolar affective disorder. Mol Psychiatry 2:457-462.
17. Lasky-Su JA, Faraone SV, Glatt SJ, Tsuang MT. 2005. Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet Part B 133B:110-115.
18. Lesch KP, et al. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
19. Lesch KP, et al. 1999. Mosaicism for a serotonin transporter gene promoter-associated deletion: Decreased recombination in depression. J Neural Transm 106:1223-1230.
20. Lim JE, Papp A, Pinsonneault J, Sadee W, Saffen D. 2006. Allelic expression of serotonin transporter (SERT) mRNA in human pons: Lack of correlation with the polymorphism SERTLPR. Mol Psychiatry 11:649-662.
21. Lotrich FE, Pollock BG. 2004. Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 14:121-129.
22. Ohara K, Nagai M, Suzuki Y, Ochiai M, Ohara K. 1998. Association between anxiety disorders and a functional polymorphism in the serotonin transporter gene. Psychiatry Res 81:277-279.
23. Parsey RV, et al. 2006. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. Am J Psychiatry 163:48-51.
24. Pezawas L, et al. 2005. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: A genetic susceptibility mechanism for depression. Nat Neurosci 8:828-834.
25. Ramasubbu R, Tobias R, Buchan AM, Bech-Hansen NT. 2006. Serotonin transporter gene promoter region polymorphism associated with poststroke major depression. J Neuropsychiatry Clin Neurosci 18:96-99.
26. Serretti A, et al. 2004. Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disorders. Am J Med Genet B 129B:36-40.
27. Sjoberg RL, et al. 2005. Development of depression: Sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. Int J Neuropsychopharmacol XX:1-7.
28. Spitzer RL, Kroenke K, Williams JBW. 1999. Validation and utility of a self-report version of PRIME-MD-The PHQ primary care study. JAMA 282:1737-1744.
29. Stober G, Heils A, Lesch KP. 1996. Serotonin transporter gene polymorphism and affective disorder. Lancet 347:1340-1341.
30. Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. 2006. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 11:224-226.
31. You JS, Hu SY, Chen B, Zhang HG. 2005. Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder. Psychiatr Genet 15:7-11.
32. Zammit S, Owen MJ. 2006. Stressful life events, 5-HTT genotype and risk of depression. Br J Psychiatry 188:199-201.
33. Zanardi R, et al. 2001. Factors affecting fluvoxamine antidepressant activity: Influence of pindolol and 5-HTTLPR in delusional and nondelusional depression. Biol Psychiatry 50:323-330.