Ligand-based design, synthesis and primary in vivo screening of pyrrole derivatives as potential tricyclic anti-inflammatory agents

Arzneimittel-Forschung/Drug Research

Volumn 56, Issue 11, 2006, Pages 753-759

  Bijev, Atanas ^a   Yaneva, Diana ^a   Bocheva, Adriana ^b   Stoev, Georgi ^c  

^a UNIVERSITY OF CHEMICAL TECHNOLOGY AND METALLURGY   (Bulgaria)

^b MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

^c National Veterinary Service   (Bulgaria)

Author keywords

Anti inflammatory drugs, non steroidal; Carrageenan induced inflammation; Pyrrole derivatives, anti inflammatory action, synthesis

Indexed keywords

4 [3 ACETYL 2 METHYL 5 PHENYL 1H 1 PYRROLYL] 1,5 DIMETHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [3 ACETYL 5 (4 CHLOROPHENYL) 2 METHYL 1H 1 PYRROLYL] 1,5 DIMETHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [3 ACETYL 5 (4 METHOXYPHENYL) 2 METHYL 1H 1 PYRROLYL] 1,5 DIMETHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 5 ARYL 1H PYRROLE DERIVATIVE; 5 [3 (ETHOXYCARBONYL) 2 METHYL 5 PHENYL 1H 1 PYRROLYL] 2 HYDROXYBENZOIC ACID; 5 [3 (ETHOXYCARBONYL) 5 (4 METHOXYPHENYL) 2 METHYL 1H 1 PYRROLYL] 2 HYDROXYBENZOIC ACID; 5 [3 ACETYL 2 METHYL 5 (4 METHYLPHENYL) 1H 1 PYROLYL] 2 HYDROXYBENZOIC ACID; 5 [3 ACETYL 2 METHYL 5 (4 METHYLPHENYL) 1H 1 PYRROLYL] 2 HYDROXYBENZOIC ACID; ANTIINFLAMMATORY AGENT; CARRAGEENAN; CAS 169590 42 5; CAS 53 86 1; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; ETHYL 1 (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H 4 PYRAZOLYL) 2 METHYL 5 PHENYL 1H 3 PYRROLECARBOXYLATE; ETHYL 1 (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H 4 PYRAZOLYL) 5 (4 CHLOROPHENYL) 2 METHYL 1H 3 PYRROLECARBOXYLATE; ETHYL 1 (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H 4 PYRAZOLYL) 5 (4 METHOXYPHENYL) 2 METHYL 1H 3 PYRROLECARBOXYLATE; ETHYL 5 (3,4 DIMETHOXYPHENYL) 2 METHYL 1 [(4 PYRIDYLCARBONYL)AMINO] 1H 3 PYRROLECARBOXYLATE; ETHYL 5 (4 CHLOROPHENYL) 2 METHYL 1 [(4 PYRIDYLCARBONYL)AMINO] 1H 3 PYRROLECARBOXYLATE; ETHYL 5 (4 METHOXYPHENYL) 2 METHYL 1 [(4 PYRIDYLCARBONYL)AMINO] 1H 3 PYRROLECARBOXYLATE; HYDROXYBENZOIC ACID DERIVATIVE; INDOMETACIN; ISONICOTINAMIDE; LIGAND; N4 (3 ACETYL 2 METHYL 5 PHENYL 1H 1 PYRROLYL)ISONICOTINAMIDE; PYRAZOLONE DERIVATIVE; PYRROLE DERIVATIVE; SALICYLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DOSE RESPONSE; DRUG DESIGN; DRUG INHIBITION; DRUG SCREENING; DRUG SYNTHESIS; IN VIVO STUDY; INFLAMMATION; MALE; NONHUMAN; PAW EDEMA; RAT; RAT STRAIN;

EID: 33845384634     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296786     Document Type: Article

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