Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene

Thrombosis and Haemostasis

Volumn 96, Issue 6, 2006, Pages 794-801

  Castellino, Francis J ^a   Ganopolsky, Jorge G ^a   Noria, Francisco ^a   Sandoval Cooper, Mayra J ^a   Ploplis, Victoria A ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

Arterial injury; Arterial neointima formation; Arterial remodeling; Inflammation; Thrombosis

Indexed keywords

COPPER; FIBRIN; PROTEIN C; SILICONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERITIS; ARTERY INTIMA; ARTERY THROMBOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CUFF; DISEASE MODEL; HETEROZYGOSITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; TISSUE NECROSIS; WILD TYPE;

ANIMALS; ARTERITIS; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CELL MOVEMENT; CELL PROLIFERATION; COPPER; DISEASE MODELS, ANIMAL; FIBRIN; FIBRINOGEN; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NECROSIS; PROTEIN C; PROTEIN C DEFICIENCY; TIME FACTORS; TUNICA INTIMA;

EID: 33845367534     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH06-08-0430     Document Type: Article

References (34)

1. Griffin JH, Evatt B, Wideman C, et al. Anticoagulant protein C pathway defective in majority of thrombophilic patients. Blood 1993; 83: 2008-9.
2. Castellino FJ. Gene targeting in hemostasis: Protein C. Front Biosci 2001; 6: D807-D19.
3. Joyce DE, Gelbert L, Ciaccia A, et al. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 276: 11199-203.
4. Kirschenbaum LA, McKevitt D, Rullan M, et al. Importance of platelets and fibrinogen in neutrophil-endothelial cell interactions in septic shock. Crit Care Med 2004; 32: 1094-9.
5. O'Brien LA, Gupta A, Grinnell BW Activated protein C and sepsis. Front Biosci 2006; 11: 676-98.
6. Cheng T, Liu D, Griffin JH. et al. Activated Protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and protects in a marine stroke model through EPCR and PAR-1. Nature Med 2003; 9: 338-42.
7. Guo H, Liu D, Gelbard H, et al. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 2004; 41: 563-72.
8. Liu D, Cheng T, Guo H, et al. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med 2004; 10: 1379-83.
9. Jalbert LR, Rosen ED, Moons L, et al. Inactivation of the gene for anticoagulant Protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest 1998; 102: 1481-8.
10. Lay AJ, Zhong L, Rosen ED, et al. Mice with a severe deficiency of protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest 2005; 115: 1552-6.
11. Murakami K, Okajima K, Uchiba M, et al. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood 1996; 87: 642-7.
12. Shibata M, Kumar SR, Amar A, et al. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation 2001; 103: 1799-805.
13. Bernard GR, Vincent JL. Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
14. Dhainaut JF, Yan SB, Margolis BD, et al. Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis. Thromb Haemost 2003; 90: 642-53.
15. Tsuchida A, Thomson NM, Salem HH, et al. Serial monitoring shows plasma protein C and free protein S levels are decreased during human acute renal allograft rejection. Transplant Proc 1990: 22: 2134-6.
16. Kiechl S, Muigg A, Sauter P, et al. Poor response to activated protein C as a prominent risk predictor of advanced atherosclerosis and arterial disease. Circulation 1999; 99: 614-9.
17. Kario K, Sakata T, Miyata T, et al. Is acquired activated protein C resistance a cardiovascular risk? Circulation 2000; 101: E120.
18. Ploplis VA. Cornelissen I, Sandoval-Cooper MJ, et al. Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1. Am J Pathol 2001; 158: 107-17.
19. Reunanen A, Knekt P, Marniemi J, et al. Serum calcium, magnesium, copper and zinc and risk of cardiovascular death. Eur J Clin Nutr 1996; 50: 431-7.
20. Mansoor MA, Bergmark C, Haswell SJ, et al. Correlation between plasma total homocysteine and copper in patients with peripheral vascular disease. Clin Chem 2000; 46: 385-91.
21. Ganopolsky JG, Castellino FJ. A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. Am J Pathol 2004; 165: 1433-46.
22. Masson P. Trichrome stainings and their preliminary technique. J Tech Meth 1929; 12: 75-90.
23. Sheehan D, Hrapchak B. Connective Tissue and Muscle Fiber Stains. In: Theory and Practice of Histotechnology. Battelle Press, Columbus, Ohio, USA 1987:196.
24. Sato J, Schorey J, Ploplis VA, et al. The fibrinolytic system in dissemination and matrix protein deposition during a Mycobacterium infection. Am J Pathol 2003; 163: 517-31.
25. Volker W, Dorszewski A, Unruh V, et al. Copper-induced inflammatory reactions of rat carotid arteries mimic restenosis/arteriosclerosis-like neointima formation. Atherosclerosis 1997; 130: 29-36.
26. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999; 340: 115-26.
27. Gerszten RE, Garcia-Zepeda EA, Lim YC, et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999; 398: 718-23.
28. Feistritzer C, Riewald M. Endotheliat barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 2005; 105: 3178-84.
29. Finigan JH, Dudek SM, Singleton PA, et al. Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. J Biol Chem 2005; 280: 17286-93.
30. Sturn DH, Kaneider NC, Feistritzer C, et al. Expression and function of the endothelial protein C receptor in human neutrophils. Blood 2003; 102: 1499-505.
31. Grey ST, Tsuchida A, Hau H, et al. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-g, or phorbol ester. J Immunol 1994; 153: 3664-72.
32. Hancock WW, Grey ST, Han L, et al. Binding of activated protein C to a specific receptor onhuman mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses. Transplantation 1995; 60: 1525-32.
33. Grey ST, Hancock WW. A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J Immunol 1996; 156: 2256-63.
34. Uchiba M, Okajima K, Oike Y, et al. Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res 2004; 95: 34-41.