Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT)

Carcinogenesis

Volumn 27, Issue 12, 2006, Pages 2442-2447

  Alyaqoub, Fadel S ^a,b,c   Tao, Lianhui ^a,b,c   Kramer, Paula M ^a,b,c   Steele, Vernon E ^a,b,c   Lubet, Ronald A ^a,b,c   Gunning, William T ^a,b,c   Pereira, Michael A ^a,b,c  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BUDESONIDE; DNA; TIPIFARNIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PREVENTION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA METHYLATION; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; FEMALE; LOW DRUG DOSE; LUNG CARCINOGENESIS; LUNG TUMOR; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BUDESONIDE; DISEASE MODELS, ANIMAL; DNA METHYLATION; DRUG THERAPY, COMBINATION; FEMALE; LUNG NEOPLASMS; MICE; MICE, INBRED A; QUINOLONES;

EID: 33845356507     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgl088     Document Type: Article

References (28)

1. Banov,C.H. (2004) The role of budesonide in adults and children with mild-to-moderate persistent asthma. J. Asthma, 41, 5-17.
2. Wattenberg,L.W., Wiedmann,T.S., Estensen,R.D., Zimmerman,C.L., Steele,V.E. and Kelloff,G.J. (1997) Chemoprevention of pulmonary carcinogenesis by aerosolized budesonide in female A/J mice. Cancer Res., 57, 5489-5492.
3. Wattenberg,L.W., Wiedmann,T.S., Estensen,R.D., Zimmerman,C.L., Galbraith,A.R., Steele,V.E. and Kelloff,G.J. (2000) Chemoprevention of pulmonary carcinogenesis by brief exposures to aerosolized budesonide or beclomethasone dipropionate and by the combination of aerosolized budesonide and dietary myo-inositol. Carcinogenesis, 21, 179-182.
4. Pereira,M.A., Li,Y., Gunning,W.T., Kramer,P.M., Alyaqoub,F.S., Lubet,R.A., Steele,V.E., Szabo,E. and Tao,L. (2002) Prevention of mouse lung tumors by budesonide and its modulation of biomarkers. Carcinogenesis, 23, 1185-1192.
5. Pereira,M.A., Tao,L.H., Wang,W., Gunning,W.T.Y. and Lubet,R.A. (2005) Chemoprevention: Mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker. Exp. Lung Res., 31, 155-163.
6. Wang,Y., Zhang,Z., Kastens,E., Lubet,R.A. and You,M. (2003) Mice with alteration in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: Differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. Cancer Res., 63, 4389-4395.
7. Estensen,R.D., Jordan,M.M., Wiemann,T.S., Galbraith,A.R., Steele,V.E. and Wattenberg,L.W. (2004) Effect of chemopreventive agents on separate stages of progression of benzo[alpha]pyrene induced lung tumors in A/J mice. Carcinogenesis, 25, 197-201.
8. Lam,S., IeRiche,J.C., McWilliams,A. et al. (2004) A randomized phase IIb trial of pulmicort turbuhaler (budesonide) in people with dysplasia of the bronchial epithelium. Clin Cancer Res., 10, 6502-6511.
9. Head,J. and Jhonston,S.R. (2004) New targets for therapy in breast cancer: Farnesyltransferase inhibitors. Breast Cancer Res., 6, 262-268.
10. Massey,T.E., Devereux,T.R., Maronpot,R.R., Foley,J.F. and Anderson,M.W. (1995) High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice. Carcinogenesis, 16, 1065-1069.
11. Cox,A.D. and Der,C.J. (2002) Ras family signaling: Therapeutic targeting. Cancer Biol. Ther., 1, 599-606.
12. Cox,A.D. and Der,C.J. (2002) Farnesyltransferase inhibitors: Promises and realities. Curr. Opin. Pharmacol., 2, 388-393.
13. Cox,A.D. (2001) Farnesyltransferase inhibitors: Potential role in the treatment of cancer. Drugs., 61, 723-732.
14. Gunning,W.T., Kramer,P.M., Lubet,R.A., Steele,V.E., End,D.W., Wouters,W. and Pereira,M.A. (2003) Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777. Clin. Cancer Res., 9, 1927-1930.
15. Adjei,A.A., Mauer,A., Bruzek,L., Marks,R.S., Hillman,S., Geyer,S., Hanson,L.J., Wright,J.J., Erlichman,C., Kaufmann,S.H. and Vokes,E.E. (2003) Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer. J. Clin. Oncol., 21, 1760-1766.
16. Mesa,R.A. (2006) Tipifarnib: Farnesyl transferase inhibition at a crossroads. Expert Rev. Anticancer Ther., 6, 313-319.
17. Esteller,M. and Herman,J.G. (2002) Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumors. J. Pathol., 196, 1-7.
18. Gaudet,F., Hodgson,J.G., Eden,A., Jackson-Grusby,L., Dausman,J., Gray,J.W., Leonhardt,H. and Jaenisch,R. (2003) Induction of tumors in mice by genomic hypomethylation. Science, 300, 489-492.
19. Goelz,S.E., Vogelstein,B., Hamilton,S.R. and Fiering,A.P. (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science, 228, 187-190.
20. Ehrlich,M. (2002) DNA methylation in cancer: Too much, but also too little. Oncogene, 21, 5400-5413.
21. Tao,L., Li,Y., Wang,W., Kramer,P.M., Gunning,W.T., Lubet,R.A., Steele,V.E. and Pereira,M.A. (2002) Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumors. Mol. Carcinog., 35, 93-102.
22. Pereira,M.A., Wang,W., Kramer,P.M. and Tao,L. (2004) Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in mice. Toxicol. Sci., 77, 243-248.
23. Tao,L., Wang,W., Kramer,P.M., Lubet,R.A., Steele,V.E. and Pereira,M.A. (2004) Modulation of DNA hypomethylation as a surrogate endpoint biomarker for chemoprevention of colon cancer. Mol. Carcinog., 39, 79-84.
24. Pereira,M.A., Tao,L., Wang,W., Li,Y., Umar,A., Steele,V.E. and Lubet,R.A. (2004) Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumors. Carcinogenesis, 25, 1917-1923.
25. Li,J. and Beer,D.G. (1995) Effect of increased glucocorticoid responsiveness in transformed mouse lung cells. Mol. Carcinog., 13, 135-145.
26. Hanson,L.A., Nuzum,E.O., Jones,B.C., Malkinson,A.M. and Beer,D.G. (1991) Expression of the glucocorticoid receptor and K-ras genes in urethan-induced mouse lung tumors and transformed cell lines. Exp. Lung Res., 17, 371-387.
27. Gunning,W.T., Kramer,P.M., Steele,V.E. and Pereira,M.A. (2002) Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice. Cancer Res., 62, 4199-4201.
28. Counts,J.L. and Goodman,J.I. (1995) Hypomethylation of DNA: A possible epigenetic mechanism involved in tumor promotion. Prog. Clin. Biol. Res., 391, 81-101.