Solid phase microextraction as a tool to determine membrane/water partition coefficients and bioavailable concentrations in in Vitro systems

Chemical Research in Toxicology

Volumn 10, Issue 10, 1997, Pages 1067-1072

  Vaes, Wouter H J ^a   Ramos, Eñaut Urrestarazu ^a   Hamwijk, Casper ^a   Van Holsteijn, Ineke ^a   Blaauboer, Bas J ^a   Seinen, Willem ^a   Verhaar, Henk J M ^a   Hermens, Joop L M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

POLYMER;

ANIMAL CELL; ARTICLE; BIOAVAILABILITY; DIAGNOSTIC APPROACH ROUTE; ECOTOXICOLOGY; EXTRACTION; MATHEMATICAL ANALYSIS; NONHUMAN; PARTITION COEFFICIENT; RAT; SOLID PHASE EXTRACTION; TECHNICAL AID;

ANIMALS; BIOLOGICAL AVAILABILITY; CELLS, CULTURED; DIMYRISTOYLPHOSPHATIDYLCHOLINE; LIVER; MALE; ONCORHYNCHUS MYKISS; RATS; RATS, WISTAR; SOLUBILITY;

EID: 0030854302     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx970109t     Document Type: Article

References (21)

1. Vaes, W. H. J., Urrestarazu Ramos, E., Verhaar, H. J. M., Seinen, W., and Hermens, J. L. M. (1996) Measurement of the free concentration using solid phase microextraction: binding to protein. Anal. Chem. 68, 4463-4467.
2. Arthur, C. L., and Pawliszyn, J. (1990) Solid phase microextraction with thermal desorption using fused silica optical fibers. Anal. Chem. 62, 2145-2148.
3. Chen, J., and Pawliszyn, J. B. (1995) Solid phase microextraction coupled to high-performance liquid chromatography. Anal. Chem. 67, 2530-2533.
4. Meyer, H. (1899) Zur Theorie der Alkoholnarkose, welche Eigenschaft der Anästhetica bedingt ihre narkotische Wirkung. Arch. Exp. Pathol. Pharmakol. 42, 109-118.
5. Overton, E. (1901) Studien über die Narkose Zugleich ein Beitrag zur Allgemeine Pharmakologie, Jens, Verlag von Gustav Fischer, Germany.
6. Van Wezel, A. P., Cornelissen, G., Van Miltenburg, J. K., and Opperhuizen, A. (1996) Membrane burdens of chlorinated benzenes lower the main phase transition temperature in dipalmitoyl-phosphaitidylcholine vesicles: implications for toxicity by narcotic chemicals. Environ. Toxicol. Chem. 15, 203-212.
7. Dulfer, W. J., and Govers, H. A. J. (1995) Membrane/water partitioning of polychlorinated biphenyls in small unilamellar vesicles of four saturated phosphatidylcholines. Environ. Sci. Technol. 29, 2548-2554.
8. Urrestarazu Ramos, E., Vaes, W. H. J., Verhaar, H. J. M., and Hermens, J. L. M. (1997) Polar narcosis: designing a suitable training set for QSAR studies. Environ. Sci. Pollut. Res. 4, 83-90.
9. Vaes, W. H. J., Hamwijk, C., Urrestarazu Ramos, E., Verhaar, H. J. M., and Hermens, J. L. M. (1996) Partitioning of organic chemicals to polyacrylate coated solid phase microextraction fibers: kinetic behavior and quantitative structure-property relationships. Anal. Chem. 68, 4458-4462.
10. Barile, F. A., Arjun, S., and Hopkinson, D. (1993) In vitro cytotoxicity testing: biological and statistical significance. Toxicol. in Vitro 7, 111-116.
11. Babich, H., and Borenfreund, E. (1991) Cytotoxicity and genotoxicity assays with cultured fish cells: a review. Toxicol. in Vitro 5, 91-100.
12. Seydel, J. K., and Schaper, K.-J. (1982) Quantitative structure-pharmacokinetic relationships and drug design. Pharmacol. Ther. 15, 131-182.
13. Gülden, M., Seibert, H., and Voss, J.-U. (1994) Inclusion of physicochemical data in quantitative comparisons of in vitro and in vivo toxic potencies. ATLA 22, 185-192.
14. Bangham, A. D., Standish, M. M., and Watkins, J. C. (1965) Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Biol. 13, 238-253.
15. Bradford, M. M. (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principles of protein-dye binding. Anal. Biochem. 72, 248-254.
16. Seglen, P. O. (1976) Preparation of isolated rat liver cells. In Methods in Cell Biology (Prescott, D. M., Ed.) Vol. XIII, pp 29-78, Academic Press, New York.
17. Paine, A. J., Williams, L. J., and Legg, R. F. (1979) Determinants of cytochrome P-450 in liver cell cultures. In The Liver: Quantitative Aspects of Structure and Function (Preisig, R., and Bircher, J., Eds.) pp 99-109, Editions Cantor, Aulendorf.
18. Gennis, R. B. (1989) Biomembranes, Molecular Structure and Function, Springer-Verlag, New York.
19. Bergmeyer, H. U., Bent, U., and Hess, B. (1965) Lactic dehydrogenase. In Methods of Enzymatic Analysis (Bergmeyer, H. U., Ed.) pp 736-743, Verlag Chemie GmbH, Weinheim.
20. Gobas, F. A. P. C., Lahittete, J. M., Garofalo, G., Ying Shiu, W., and Mackay, D. (1988) A novel method for measuring membrane/ water partition coefficients of hydrophobic organic chemicals: comparisons with 1-octanol/water partitioning. J. Pharmacol. Sci. 77, 265-272.
21. Guillouzo, A., Morel, F., Ratanasavanh, D., Chesné, C., and Guguen-Guillouzo, C. (1990) Long-term culture of functional hepatocytes. Toxicol. in Vitro 4, 415-427.