Effects and mechanism of Chinese Tarantula Toxins on the Kv2.1 potassium channels

Biochemical and Biophysical Research Communications

Volumn 352, Issue 3, 2007, Pages 799-804

  Yuan, Chunhua ^a   Yang, Shengqing ^a   Liao, Zhi ^a   Liang, Songping ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Gating modifier; Kv2.1 channel; Kv4.1 channel; Spider

Indexed keywords

AMINO ACID; CHINESE TARANTULA VENOM; JINGZHAOTOXIN I; JINGZHAOTOXIN III; JINGZHAOTOXIN V; NEUROTOXIN; POTASSIUM CHANNEL; SPIDER VENOM; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANISOTROPY; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CHINESE TARANTULA; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BINDING; DRUG EFFECT; DRUG MECHANISM; ELECTRICITY; ELECTROPHYSIOLOGY; FEMALE; INHIBITION KINETICS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SPIDER; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ION CHANNEL GATING; MEMBRANE POTENTIALS; OOCYTES; SHAB POTASSIUM CHANNELS; SPIDER VENOMS; XENOPUS LAEVIS;

ARANEAE; CHILOBRACHYS JINGZHAO; TARANTULA; XENOPUS LAEVIS;

EID: 33845301202     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.11.086     Document Type: Article

References (22)

1. Miller C. The charybdotoxin family of K+ channel-blocking peptides. Neuron 15 (1995) 5-10
2. Gilquin B., Racape J., Wrisch A., Visan V., Lecoq A., Grissmer S., Menez A., and Gasparini S. Structure of the BgK-Kv1.1 complex based on distance restraints identified by double mutant cycles. Molecular basis for convergent evolution of Kv1 channel blockers. J. Biol. Chem. 277 (2002) 37406-37413
3. +-channel protein identified by its binding properties for dendrotoxin I. Proc. Natl. Acad. Sci. USA 85 (1988) 4919-4923
4. + channel through multiple binding sites. Neuron 18 (1997) 665-673
5. Takahashi H., Kim J.I., Min H.J., Sato K., Swartz K.J., and Shimada I. Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins. J. Mol. Biol. 297 (2000) 771-780
6. Lee S.Y., and MacKinnon R. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430 (2004) 232-235
7. Middleton R.E., Warren V.A., Kraus R.L., Hwang J.C., Liu C.J., Dai G., Brochu R.M., Kohler M.G., Gao Y.D., Garsky V.M., Bogusky M.J., Mehl J.T., Cohen C.J., and Smith M.M. Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry 41 (2002) 14734-14747
8. Marvin L., De E., Cosette P., Gagnon J., Molle G., and Lange C. Isolation, amino acid sequence and functional assays of SGTx1. The first toxin purified from the venom of the spider scodra griseipes. Eur. J. Biochem. 265 (1999) 572-579
9. Sidach S.S., and Mintz I.M. Kurtoxin, a gating modifier of neuronal high- and low-threshold Ca channels. J. Neurosci. 22 (2002) 2023-2034
10. Xiao Y., Tang J., Hu W., Xie J., Maertens C., Tytgat J., and Liang S. Jingzhaotoxin-I, a novel spider neurotoxin preferentially inhibiting cardiac sodium channel inactivation. J. Biol. Chem. 280 (2005) 12069-12076
11. Xiao Y., Tang J., Yang Y., Wang M., Hu W., Xie J., Zeng X., and Liang S. Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes. J. Biol. Chem. 279 (2004) 26220-26226
12. Krieg P.A., and Melton D.A. In vitro RNA synthesis with SP6 RNA polymerase. Methods Enzymol. 155 (1987) 397-415
13. Thompson J.D., Gibson T.J., Plewniak F., Jeanmougin F., and Higgins D.G. The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res. 25 (1997) 4876-4882
14. Saitou N., and Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol. 4 (1987) 406-425
15. Phillips L.R., Milescu M., Li-Smerin Y., Mindell J.A., Kim J.I., and Swartz K.J. Voltage-sensor activation with a tarantula toxin as cargo. Nature 436 (2005) 857-860
16. Wang J.M., Roh S.H., Kim S., Lee C.W., Kim J.I., and Swartz K.J. Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels. J. Gen. Physiol. 123 (2004) 455-467
17. Escoubas P., Diochot S., Celerier M.L., Nakajima T., and Lazdunski M. Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol. Pharmacol. 62 (2002) 48-57
18. Herrington J., Zhou Y.P., Bugianesi R.M., Dulski P.M., Feng Y., Warren V.A., Smith M.M., Kohler M.G., Garsky V.M., Sanchez M., Wagner M., Raphaelli K., Banerjee P., Ahaghotu C., Wunderler D., Priest B.T., Mehl J.T., Garcia M.L., McManus O.B., Kaczorowski G.J., and Slaughter R.S. Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes 55 (2006) 1034-1042
19. Swartz K.J., and MacKinnon R. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron 15 (1995) 941-949
20. Jung H.J., Kim P.I., Lee S.K., Lee C.W., Eu Y.J., Lee D.G., Earm Y.E., and Kim J.I. Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem. Biophys. Res. Commun. 340 (2006) 633-638
21. Diochot S., Drici M.D., Moinier D., Fink M., and Lazdunski M. Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis. Br. J. Pharmacol. 126 (1999) 251-263
22. Chagot B., Escoubas P., Villegas E., Bernard C., Ferrat G., Corzo G., Lazdunski M., and Darbon H. Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci. 13 (2004) 1197-1208