Contribution of microbiological investigations to the diagnosis of lower respiratory tract infections;04 - Apport des explorations microbiologiques au diagnostic des infections des voies respiratoires basses

Medecine et Maladies Infectieuses

Volumn 36, Issue 11-12, 2006, Pages 570-598

  Leroy, O ^a  

^a Service de Réanimation Médicale et Maladies Infectieuses Hôpital Chatiliez Rue du Président Coty   (France)

Author keywords

Bacteriological investigations; Community acquired pneumonia

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ANTIGEN; BETA LACTAM ANTIBIOTIC; CEFOTAXIME; CEFTRIAXONE; CEPHALOSPORIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEVOFLOXACIN; MACROLIDE; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VIRUS ANTIGEN;

ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; BACTERIAL PNEUMONIA; BACTERIOLOGY; BLOOD CULTURE; CHLAMYDOPHILA PNEUMONIAE; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMBINATION CHEMOTHERAPY; COMMUNITY ACQUIRED PNEUMONIA; COXIELLA BURNETII; CYTOLOGY; DIAGNOSTIC PROCEDURE; DIAGNOSTIC TEST; DISEASE EXACERBATION; DRUG EFFECT; DRUG TREATMENT FAILURE; ENZYME IMMUNOASSAY; GROUPS BY AGE; HUMAN; INFECTION RISK; INFLUENZA; INFLUENZA VIRUS; INFLUENZA VIRUS A; INFLUENZA VIRUS B; LEGIONELLA PNEUMOPHILA; LOBAR PNEUMONIA; LOWER RESPIRATORY TRACT INFECTION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIOLOGICAL EXAMINATION; MONOTHERAPY; MYCOPLASMA PNEUMONIAE; PARAINFLUENZA VIRUS; POLYMERASE CHAIN REACTION; PROGNOSIS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SARS CORONAVIRUS; SEROLOGY; SPUTUM ANALYSIS; STREPTOCOCCUS PNEUMONIAE; URINALYSIS; VIRUS GENOME; ACUTE DISEASE; ANIMAL; COMMUNICABLE DISEASE; DIFFERENTIAL DIAGNOSIS; DISEASE TRANSMISSION; LEGIONNAIRE DISEASE; PNEUMONIA; RESPIRATORY TRACT INFECTION; REVIEW;

ACUTE DISEASE; ANIMALS; COMMUNITY-ACQUIRED INFECTIONS; DIAGNOSIS, DIFFERENTIAL; HUMANS; LEGIONNAIRES' DISEASE; PNEUMONIA; RESPIRATORY TRACT INFECTIONS;

EID: 33845227934     PISSN: 0399077X     EISSN: 17696690     Source Type: Journal    
DOI: 10.1016/j.medmal.2006.07.008     Document Type: Article

References (174)

1. Agence française de sécurité sanitaire des produits de santé. Antibiothérapie par voie générale en pratique courante : exacerbations de bronchite chronique (2001)
2. Agence française de sécurité Sanitaire des produits de santé. Antibiothérapie par voie générale en pratique courante : infections respiratoires basses de l'adulte (2003)
3. Reed W.W., Byrd G.S., Gates Jr. R.H., Howard R.S., and Weaver M.J. Sputum Gram's stain in community-acquired pneumococcal pneumonia. A meta-analysis. West. J. Med. 165 (1996) 197-204
4. Cooper G.M., Jones J.J., Arbique J.C., Flowerdew G.J., and Forward K.R. Intra and intertechnologist variability in the quality assessment of respiratory tract specimens. Diagn. Microbiol. Infect. Dis. 37 (2000) 231-235
5. Nagendra S., Bourbeau P., Brecher S., Dunne M., LaRocco M., and Doern G. Sampling variability in the microbiological evaluation of expectorated sputa and endotracheal aspirates. J. Clin. Microbiol. 39 (2001) 2344-2347
6. Huchon G., Chidiac C., Delaval P., Leophonte P., Mouton Y., Roche N., et al. Conduite à tenir devant une infection respiratoire basse communautaire de l'adulte. Rev. Mal. Respir. 16 (1999) 224-233
7. Marrie T.J., Poulin-Costello M., Beecroft M.D., and Herman-Gnjidic Z. Etiology of community-acquired pneumonia treated in an ambulatory setting. Respir. Med. 99 (2005) 60-65
8. Theerthakarai R., El-Halees W., Ismail M., Solis R.A., and Khan M.A. Nonvalue of the initial microbiological studies in the management of nonsevere community-acquired pneumonia. Chest 119 (2001) 181-184
9. Roson B., Carratala J., Verdaguer R., Dorca J., Manresa F., and Gudiol F. Prospective study of the usefulness of sputum Gram stain in the initial approach to community-acquired pneumonia requiring hospitalization. Clin. Infect. Dis. 31 (2000) 869-874
10. Garcia-Vazquez E., Marcos M.A., Mensa J., de Roux A., Puig J., Font C., et al. Assessment of the usefulness of sputum culture for diagnosis of community-acquired pneumonia using the PORT predictive scoring system. Arch. Intern. Med. 164 (2004) 1807-1811
11. Drew W.L. Value of sputum culture in diagnosis of pneumococcal pneumonia. J. Clin. Microbiol. 6 (1977) 62-65
12. Guzzetta P., Toews G.B., Robertson K.J., and Pierce A.K. Rapid diagnosis of community-acquired bacterial pneumonia. Am. Rev. Respir. Dis. 128 (1983) 461-464
13. Gleckman R., DeVita J., Hibert D., Pelletier C., and Martin R. Sputum gram stain assessment in community-acquired bacteremic pneumonia. J. Clin. Microbiol. 26 (1988) 846-849
14. Watanakunakorn C., and Bailey T.A. Adult bacteremic pneumococcal pneumonia in a community teaching hospital, 1992-1996: a detailed analysis of 108 cases. Arch. Intern. Med. 157 (1997) 1965-1971
15. Musher D.M., Montoya R., and Wanahita A. Diagnostic value of microscopic examination of Gram-stained sputum and sputum cultures in patients with bacteremic pneumococcal pneumonia. Clin. Infect. Dis. 39 (2004) 165-169
16. Campbell S.G., Marrie T.J., Anstey R., Ackroyd-Stolarz S., and Dickinson G. Utility of blood cultures in the management of adults with community acquired pneumonia discharged from the emergency department. Emerg. Med. J. 20 (2003) 521-523
17. Waterer G.W., and Wunderink R.G. The influence of the severity of community-acquired pneumonia on the usefulness of blood cultures. Respir. Med. 95 (2001) 78-82
18. Chalasani N.P., Valdecanas M.A., Gopal A.K., McGowan Jr. J.E., and Jurado R.L. Clinical utility of blood cultures in adult patients with community-acquired pneumonia without defined underlying risks. Chest 108 (1995) 932-936
19. Metersky M.L., Ma A., Bratzler D.W., and Houck P.M. Predicting bacteremia in patients with community-acquired pneumonia. Am. J. Respir. Crit. Care Med. 169 (2004) 342-347
20. Levy M., Dromer F., Brion N., Leturdu F., and Carbon C. Community-acquired pneumonia. Importance of initial noninvasive bacteriologic and radiographic investigations. Chest 93 (1988) 43-48
21. Campbell S.G., Marrie T.J., Anstey R., Dickinson G., and Ackroyd-Stolarz S. The contribution of blood cultures to the clinical management of adult patients admitted to the hospital with community-acquired pneumonia: a prospective observational study. Chest 123 (2003) 1142-1150
22. Leroy O., Santre C., Beuscart C., Georges H., Guery B., Jacquier J.M., et al. A five-year study of severe community-acquired pneumonia with emphasis on prognosis in patients admitted to an intensive care unit. Intensive Care Med. 21 (1995) 24-31
23. Torres A., Serra-Batlles J., Ferrer A., Jimenez P., Celis R., Cobo E., et al. Severe community-acquired pneumonia. Epidemiology and prognostic factors. Am. Rev. Respir. Dis. 144 (1991) 312-318
24. Rello J., Bodi M., Mariscal D., Navarro M., Diaz E., Gallego M., et al. Microbiological testing and outcome of patients with severe community-acquired pneumonia. Chest 123 (2003) 174-180
25. Paganin F., Lilienthal F., Bourdin A., Lugagne N., Tixier F., Genin R., et al. Severe community-acquired pneumonia: assessment of microbial aetiology as mortality factor. Eur. Respir. J. 24 (2004) 779-785
26. Moine P., Vercken J.B., Chevret S., Chastang C., and Gajdos P. Severe community-acquired pneumonia. Etiology, epidemiology, and prognosis factors. French Study Group for Community-Acquired Pneumonia in the Intensive Care Unit. Chest 105 (1994) 1487-1495
27. Dominguez J., Gali N., Blanco S., Pedroso P., Prat C., Matas L., et al. Detection of Streptococcus pneumoniae antigen by a rapid immunochromatographic assay in urine samples. Chest 119 (2001) 243-249
28. Murdoch D.R., Laing R.T., Mills G.D., Karalus N.C., Town G.I., Mirrett S., et al. Evaluation of a rapid immunochromatographic test for detection of Streptococcus pneumoniae antigen in urine samples from adults with community-acquired pneumonia. J. Clin. Microbiol. 39 (2001) 3495-3498
29. Gutierrez F., Masia M., Rodriguez J.C., Ayelo A., Soldan B., Cebrian L., et al. Evaluation of the immunochromatographic Binax NOW assay for detection of Streptococcus pneumoniae urinary antigen in a prospective study of community-acquired pneumonia in Spain. Clin. Infect. Dis. 36 (2003) 286-292
30. Marcos M.A., Jimenez de Anta M.T., de la Bellacasa J.P., Gonzalez J., Martinez E., Garcia E., et al. Rapid urinary antigen test for diagnosis of pneumococcal community-acquired pneumonia in adults. Eur. Respir. J. 21 (2003) 209-214
31. Smith M.D., Derrington P., Evans R., Creek M., Morris R., Dance D.A., et al. Rapid diagnosis of bacteremic pneumococcal infections in adults by using the Binax NOW Streptococcus pneumoniae urinary antigen test: a prospective, controlled clinical evaluation. J. Clin. Microbiol. 41 (2003) 2810-2813
32. Honoré S., Trillard M., Ould-Hocine Z., Lesprit P., Deforges L., and Legrand P. Contribution of urinary pneumococcal antigen detection combined with the research of Legionella antigen for diagnosis of pneumonia in hospitalized patients. Pathol. Biol. 52 (2004) 429-433
33. Dowell S.F., Garman R.L., Liu G., Levine O.S., and Yang Y.H. Evaluation of Binax NOW, an assay for the detection of pneumococcal antigen in urine samples, performed among pediatric patients. Clin. Infect. Dis. 32 (2001) 824-825
34. Hamer D.H., Egas J., Estrella B., MacLeod W.B., Griffiths J.K., and Sempertegui F. Assessment of the Binax NOW Streptococcus pneumoniae urinary antigen test in children with nasopharyngeal pneumococcal carriage. Clin. Infect. Dis. 34 (2002) 1025-1028
35. Murdoch D.R., Laing R.T., and Cook J.M. The NOW S. pneumoniae urinary antigen test positivity rate 6 weeks after pneumonia onset and among patients with COPD. Clin. Infect. Dis. 37 (2003) 153-154
36. Weiss K., and Tillotson G.S. The controversy of combination vs monotherapy in the treatment of hospitalized community-acquired pneumonia. Chest 128 (2005) 940-946
37. Pesola G.R. The urinary antigen test for the diagnosis of pneumococcal pneumonia. Chest 119 (2001) 9-11
38. Den Boer J.W., and Yzerman E.P.F. Diagnosis of Legionella infection in legionnaires'disease. Eur. J. Clin. Microbiol. Infect. Dis. 23 (2004) 871-878
39. Waterer G.W., Baselski V.S., and Wunderink R.G. Legionella and community-acquired pneumonia: a review of current diagnostic tests from a clinician's viewpoint. Am. J. Med. 110 (2001) 41-44
40. Fields B.S., Benson R.F., and Besser R.E. Legionella and Legionnaires' disease: 25 years of investigation. Clin. Microbiol. Rev. 15 (2002) 506-526
41. Jarraud S., Girardo P., Reyrolle M., Forey F., and Etienne J. Current biological assessment of Legionellosis. Med. Mal. Infect. 34 Suppl 1 (2004) 7-9
42. Benhamou D., Bru J.P., Chidiac C., Etienne J., Léophonte P., Marty N., et al. Société de pneumologie de langue française (SPLF); Société de pathologie Infectieuse de langue française (SPILF) ; centre national de référence sur les légionelles. Legionnaire's disease: definition, diagnosis and treatment. Med. Mal. Infect. 35 (2005) 1-5
43. Waites K.B., and Talkington D.F. Mycoplasma pneumoniae and its role as a human pathogen. Clin. Microbiol. Rev. 17 (2004) 697-728
44. Daxboeck F., Krause R., and Wenisch C. Laboratory diagnosis of Mycoplasma pneumoniae infection. Clin. Microbiol. Infect. 9 (2003) 263-273
45. Grayston J.T., Foy H.M., and Kenny C. The epidemiology of mycoplasma infections of the respiratory tract. In: Hayflick L. (Ed). The mycoplasmatales and L phase of bacteria (1969), North Holland, Amsterdam 651-682
46. Gnarpe J., Lundback A., Gnarpe H., and Sundelof B. Comparison of nasopharyngeal and throat swabs for the detection of Chlamydia pneumoniae and Mycoplasma pneumoniae by polymerase chain reaction. Scand. J. Infect. Dis. 104 Suppl (1997) 11-12
47. Hammerschlag M.R. Current status of laboratory diagnosis of Chlamydia pneumoniae and Chlamydia psittaci. Clin. Microbiol. Newsl. 23 (2001) 107-111
48. Dowell S.F., Peeling R.W., Boman J., Carlone G.M., Fields B.S., Guarner J., et al. C. pneumoniae Workshop Participants. Standardizing Chlamydia pneumoniae assays: recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada). Clin. Infect. Dis. 33 (2001) 492-503
49. Sopena N., Sabria-Leal M., Pedro-Botet M.L., Padilla E., Dominguez J., Morera J., et al. Comparative study of the clinical presentation of Legionella pneumonia and other community-acquired pneumonias. Chest 113 (1998) 1195-1200
50. Blanquer J., Blanquer R., Borras R., Nauffal D., Morales P., Menendez R., et al. Aetiology of community acquired pneumonia in Valencia, Spain: a multicentre prospective study. Thorax 46 (1991) 508-511
51. Bates J.H., Campbell G.D., Barron A.L., McCracken G.A., Morgan P.N., Moses E.B., et al. Microbial etiology of acute pneumonia in hospitalized patients. Chest 101 (1992) 1005-1012
52. Steele T.W. Legionnaires' disease in South Australia, 1979-1988. Med. J. Aust. 151 (1989) 322-328
53. Zuravleff J.J., Yu V.L., Shonnard J.W., Davis B.K., and Rihs J.D. Diagnosis of legionnaires' disease. An update of laboratory methods with new emphasis on isolation by culture. JAMA 250 (1983) 1981-1985
54. Saravolatz L.D., Russell G., and Cvitkovich D. Direct immunofluorescence in the diagnosis of legionnaires' disease. Chest 79 (1981) 566-570
55. Ruf B., Schurmann D., Horbach I., Fehrenbach F.J., and Pohle H.D. Prevalence and diagnosis of Legionella pneumonia: a 3-year prospective study with emphasis on application of urinary antigen detection. J. Infect. Dis. 162 (1990) 1341-1348
56. Plouffe J.F., File Jr. T.M., Breiman R.F., Hackman B.A., Salstrom S.J., Marston B.J., et al. Reevaluation of the definition of legionnaires' disease: use of the urinary antigen assay. Community Based Pneumonia Incidence Study Group. Clin. Infect. Dis. 20 (1995) 1286-1291
57. Mandell L.A., Bartlett J.G., Dowell S.F., File Jr. T.M., Musher D.M., and Whitney C. Infectious Diseases Society of America. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin. Infect. Dis. 37 (2003) 1405-1433
58. Beersma M.F., Dirven K., van Dam A.P., Templeton K.E., Claas E.C., and Goossens H. Evaluation of 12 commercial tests and the complement fixation test for Mycoplasma pneumoniae-specific immunoglobulin G (IgG) and IgM antibodies, with PCR used as the "gold standard". J. Clin. Microbiol. 43 (2005) 2277-2285
59. Scott J.A.G., and Hall A.J. The value and complications of percutaneous transthoracic lung aspiration for the etiologic diagnosis of community-acquired pneumonia. Chest 116 (1999) 1716-1732
60. Marquette C.H., Tonnel, and AB. Apport et limites des techniques endoscopiques pour le diagnostic des pneumonies bactériennes communautaires. In: Léophonte P., and Mouton Y. (Eds). Repères sur les infections broncho-pulmonaires, 3e Edition (2001), PIL 161-169
61. Jimenez P., Saldias F., Meneses M., Silva M.E., Wilson M.G., and Otth L. Diagnostic fiberoptic bronchoscopy in patients with community-acquired pneumonia. Comparison between bronchoalveolar lavage and telescoping plugged catheter cultures. Chest 103 (1993) 1023-1027
62. Vives L., Biel P., Maler G., Labonne F., Lecoules N., Dufour M., et al. Acute community-acquired pneumonia of moderate and grave severity investigated by bronchoscopy. Analysis of 193 cases hospitalized in a general hospital. Rev. Mal. Respir. 13 (1996) 175-182
63. Rodriguez R.M., Fancher M.L., Phelps M., Hawkins K., Johnson J., Stacks K., et al. An emergency department-based randomized trial of nonbronchoscopic bronchoalveolar lavage for early pathogen identification in severe community-acquired pneumonia. Ann. Emerg. Med. 38 (2001) 357-363
64. Ortqvist A., Kalin M., Lejdeborn L., and Lundberg B. Diagnostic fiberoptic bronchoscopy and protected brush culture in patients with community-acquired pneumonia. Chest 97 (1990) 576-582
65. Feinsilver S.H., Fein A.M., Niederman M.S., Schultz D.E., and Faegenburg D.H. Utility of fiberoptic bronchoscopy in nonresolving pneumonia. Chest 98 (1990) 1322-1326
66. Arancibia F., Ewig S., Martinez J.A., Ruiz M., Bauer T., Marcos M.A., et al. Antimicrobial treatment failures in patients with community-acquired pneumonia: causes and prognostic implications. Am. J. Respir. Crit. Care Med. 162 (2000) 154-160
67. El-Solh A.A., Aquilina A.T., Dhillon R.S., Ramadan F., Nowak P., and Davies J. Impact of invasive strategy on management of antimicrobial treatment failure in institutionalized older people with severe pneumonia. Am. J. Respir. Crit. Care Med. 166 (2002) 1038-1043
68. Woodhead M. Community-acquired pneumonia in Europe: causative pathogens and resistance patterns. Eur. Respir. J. 36 Suppl (2002) 20-27
69. Wattanathum A., Chaoprasong C., Nunthapisud P., Chantaratchada S., Limpairojn N., Jatakanon A., et al. Community-acquired pneumonia in southeast Asia: the microbial differences between ambulatory and hospitalized patients. Chest 123 (2003) 1512-1519
70. Ruiz M., Ewig S., Marcos M.A., Martinez J.A., Arancibia F., Mensa J., et al. Etiology of community-acquired pneumonia: impact of age, comorbidity, and severity. Am. J. Respir. Crit. Care Med. 160 (1999) 397-405
71. Ruiz M., Ewig S., Torres A., Arancibia F., Marco F., Mensa J., et al. Severe community-acquired pneumonia. Risk factors and follow-up epidemiology. Am. J. Respir. Crit. Care Med. 160 (1999) 923-929
72. Roson B., Carratala J., Dorca J., Casanova A., Manresa F., and Gudiol F. Etiology, reasons for hospitalization, risk classes, and outcomes of community-acquired pneumonia in patients hospitalized on the basis of conventional admission criteria. Clin. Infect. Dis. 33 (2001) 158-165
73. Agence française de sécurité sanitaire des produits de santé. Recommandations de bonne pratique. Antibiothérapie par voie générale en pratique courante : infections ORL et respiratoires basses. Mise à jour (1999)
74. Marrie T.J., Peeling R.W., Reid T., De Carolis E., and Canadian Community-Acquired Pneumonia Investigators. Chlamydia species as a cause of community-acquired pneumonia in Canada. Eur. Respir. J. 21 (2003) 779-784
75. Socan M., Kosmelj K., Marinic-Fiser N., and Vidmar L. A prediction model for community-acquired Chlamydia pneumoniae pneumonia in hospitalized patients. Infection 32 (2004) 204-209
76. Sopena N., Pedro-Botet M.L., Sabria M., Garcia-Pares D., Reynaga E., and Garcia-Nunez M. Comparative study of community-acquired pneumonia caused by Streptococcus pneumoniae, Legionella pneumophila or Chlamydia pneumoniae. Scand. J. Infect. Dis. 36 (2004) 330-334
77. de Roux A., Marcos M.A., Garcia E., Mensa J., Ewig S., Lode H., et al. Viral community-acquired pneumonia in nonimmunocompromised adults. Chest 125 (2004) 1343-1351
78. Janssens J.P., and Krause K.H. Pneumonia in the very old. Lancet Infect. Dis. 4 (2004) 112-124
79. Muder R.R. Pneumonia in residents of long-term care facilities: epidemiology, etiology, management, and prevention. Am. J. Med. 105 (1998) 319-330
80. Fein A.M. Pneumonia in the elderly: overview of diagnostic and therapeutic approaches. Clin. Infect. Dis. 28 (1999) 726-729
81. Marrie T.J. Community-acquired pneumonia in the elderly. Clin. Infect. Dis. 31 (2000) 1066-1078
82. Mylotte J.M. Nursing home-acquired pneumonia. Clin. Infect. Dis. 35 (2002) 1205-1211
83. Loeb M. Pneumonia in older persons. Clin. Infect. Dis. 37 (2003) 1335-1339
84. Kaplan V., Angus D.C., Griffin M.F., Clermont G., Scott Watson R., and Linde-Zwirble W.T. Hospitalized community-acquired pneumonia in the elderly: age--and sex-related patterns of care and outcome in the United States. Am. J. Respir. Crit. Care Med. 165 (2002) 766-772
85. Lim W.S., Macfarlane J.T., Boswell T.C., Harrison T.G., Rose D., Leinonen M., et al. Study of community acquired pneumonia aetiology (SCAPA) in adults admitted to hospital: implications for management guidelines. Thorax 56 (2001) 296-301
86. Leroy O., Bosquet C., Vandenbussche C., Coffinier C., Georges H., Guery B., et al. Community-acquired pneumonia in the intensive care unit: epidemiological and prognosis data in older people. J. Am. Geriatr. Soc. 47 (1999) 539-546
87. Lim W.S., and Macfarlane J.T. A prospective comparison of nursing home acquired pneumonia with community acquired pneumonia. Eur. Respir. J. 18 (2001) 362-368
88. El-Solh A.A., Sikka P., Ramadan F., and Davies J. Etiology of severe pneumonia in the very elderly. Am. J. Respir. Crit. Care Med. 163 (2001) 645-651
89. Niederman M.S., Mandell L.A., Anzueto A., Bass J.B., Broughton W.A., Campbell G.D., et al. American Thoracic Society. Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am. J. Respir. Crit. Care Med. 163 (2001) 1730-1754
90. British Thoracic Society Standards of Care Committee. BTS Guidelines for the Management of Community Acquired Pneumonia in Adults. Thorax 56 Suppl 4 (2001) 1-64
91. Bartlett J.G., Dowell S.F., Mandell L.A., File Jr. T.M., Musher D.M., and Fine M.J. Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Diseases Society of America. Clin. Infect. Dis. 31 (2000) 347-382
92. Balaguera H.U., Mir J., and Craven D.E. Nosocomial or healthcare facility-related pneumonia in adults. Curr. Infect. Dis. Rep. 2 (2000) 215-223
93. El Solh A.A., Pietrantoni C., Bhat A., Bhora M., and Berbary E. Indicators of potentially drug-resistant bacteria in severe nursing home-acquired pneumonia. Clin. Infect. Dis. 39 (2004) 474-480
94. Lidman C., Burman L.G., Lagergren A., and Ortqvist A. Limited value of routine microbiological diagnostics in patients hospitalized for community-acquired pneumonia. Scand. J. Infect. Dis. 34 (2002) 873-879
95. Van der Eerden M.M., Vlaspolder F., de Graaff C.S., Groot T., Bronsveld W., Jansen H.M., et al. Comparison between pathogen directed antibiotic treatment and empirical broad spectrum antibiotic treatment in patients with community acquired pneumonia: a prospective randomised study. Thorax 60 (2005) 672-678
96. Sanyal S., Smith P.R., Saha A.C., Gupta S., Berkowitz L., and Homel P. Initial microbiologic studies did not affect outcome in adults hospitalized with community-acquired pneumonia. Am. J. Respir. Crit. Care Med. 160 (1999) 346-348
97. Roson B., Carratala J., Fernandez-Sabe N., Tubau F., Manresa F., and Gudiol F. Causes and factors associated with early failure in hospitalized patients with community-acquired pneumonia. Arch. Intern. Med. 164 (2004) 502-508
98. Yu V.L., Chiou C.C., Feldman C., Ortqvist A., Rello J., Morris A.J., et al. International Pneumococcal Study Group. An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome. Clin. Infect. Dis. 37 (2003) 230-237
99. Lujan M., Gallego M., Fontanals D., Mariscal D., and Rello J. Prospective observational study of bacteremic pneumococcal pneumonia: Effect of discordant therapy on mortality. Crit. Care Med. 32 (2004) 625-631
100. Meehan T.P., Fine M.J., Krumholz H.M., Scinto J.D., Galusha D.H., Mockalis J.T., et al. Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA 278 (1997) 2080-2084
101. Houck P.M., Bratzler D.W., Nsa W., Ma A., and Bartlett J.G. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch. Intern. Med. 164 (2004) 637-644
102. Oosterheert J.J., Bonten M.J., Hak E., Schneider M.M., and Hoepelman I.M. How good is the evidence for the recommended empirical antimicrobial treatment of patients hospitalized because of community-acquired pneumonia? A systematic review. J. Antimicrob. Chemother. 52 (2003) 555-563
103. Gleason P.P., Meehan T.P., Fine J.M., Galusha D.H., and Fine M.J. Associations between initial antimicrobial therapy and medical outcomes for hospitalized elderly patients with pneumonia. Arch. Intern. Med. 159 (1999) 2562-2572
104. Brown R.B., Iannini P., Gross P., and Kunkel M. Impact of initial antibiotic choice on clinical outcomes in community-acquired pneumonia: analysis of a hospital claims-made database. Chest 123 (2003) 1503-1511
105. Marrie T.J., and Wu L. Factors influencing in-hospital mortality in community-acquired pneumonia. A prospective study of patients not initially admitted to the ICU. Chest 127 (2005) 1260-1270
106. Waterer G.W., Somes G.W., and Wunderink R.G. Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia. Arch. Intern. Med. 161 (2001) 1837-1842
107. Martinez J.A., Horcajada J.P., Almela M., Marco F., Soriano A., Garcia E., et al. Addition of a macrolide to a ß-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia. Clin. Infect. Dis. 36 (2003) 389-395
108. Baddour L.M., Yu V.L., Klugman K.P., Feldman C., Ortqvist A., Rello J., et al. International Pneumococcal Study Group. Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia. Am. J. Respir. Crit. Care Med. 170 (2004) 440-444
109. Ewig S., Bauer T., Hasper E., Marklein G., Kubini R., and Luderitz B. Value of routine microbial investigation in community-acquired pneumonia treated in a tertiary care centre. Respiration (Herrlisheim) 63 (1996) 164-169
110. Ewig S., Schlochtermeier M., Goke N., and Niederman M.S. Applying sputum as a diagnostic tool in pneumonia: limited yield, minimal impact on treatment decisions. Chest 121 (2002) 1486-1492
111. Waterer G.W., Jennings S.G., and Wunderink R.G. The impact of blood cultures on antibiotic therapy in pneumococcal pneumonia. Chest 116 (1999) 1278-1281
112. Mandell L.A., Bartlett J.G., Dowell S.F., File Jr. T.M., Musher D.M., and Whitney C. Infectious Diseases Society of America. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin. Infect. Dis. 37 (2003) 1405-1433
113. Macfarlane J.T., and Boldy D. 2004 update of BTS pneumonia guidelines: what's new?. Thorax 59 (2004) 364-366
114. Mackie P.L. The classification of viruses infecting the respiratory tract. Paediatr. Respir. Rev. 4 (2003) 84-90
115. Louie J.K., Hacker J.K., Gonzales R., Mark J., Maselli J.H., Yagi S., et al. Characterization of viral agents causing acute respiratory infection in a San Francisco University Medical Center Clinic during the influenza season. Clin. Infect. Dis. 41 (2005) 822-828
116. Han L.L., Alexander J.P., and Anderson L.J. Respiratory syncytial virus pneumonia among the elderly: an assessment of disease burden. J. Infect. Dis. 179 (1999) 25-30
117. Falsey A.R., Walsh E.E., and Hayden F.G. Rhinovirus and coronavirus infection-associated hospitalizations among older adults. J. Infect. Dis. 185 (2002) 1338-1341
118. Frangides C.Y., and Pneumatikos I. Varicella-zoster virus pneumonia in adults: report of 14 cases and review of the literature. Eur. J. Intern. Med. 15 (2004) 364-370
119. Falsey A.R., Hennessey P.A., Formica M.A., Cox C., and Walsh E.E. Respiratory syncytial virus infection in elderly and high-risk adults. N. Engl. J. Med. 352 (2005) 1749-1759
120. Boivin G., Abed Y., Pelletier G., Ruel L., Moisan D., Cote S., et al. Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J. Infect. Dis. 186 (2002) 1330-1334
121. Peiris J.S., Lai S.T., Poon L.L., Guan Y., Yam L.Y., Lim W., et al. SARS study group. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361 (2003) 1319-1325
122. Hamelin M.E., Cote S., Laforge J., Lampron N., Bourbeau J., Weiss K., et al. Human metapneumovirus infection in adults with community-acquired pneumonia and exacerbation of chronic obstructive pulmonary disease. Clin. Infect. Dis. 41 (2005) 498-502
123. The Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5. Avian influenza A (H5N1) infection in humans. N. Engl. J. Med. 353 (2005) 1374-1385
124. Snell N.J. New treatments for viral respiratory tract infections--opportunities and problems. J. Antimicrob. Chemother. 47 (2001) 251-259
125. Barenfanger J., Drake C., Leon N., Mueller T., and Troutt T. Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study. J. Clin. Microbiol. 38 (2000) 2824-2828
126. Reina J., Munar M., and Blanco I. Evaluation of a direct immunofluorescence assay, dot-blot enzyme immunoassay, and shell vial culture in the diagnosis of lower respiratory tract infections caused by influenza A virus. Diagn. Microbiol. Infect. Dis. 25 (1996) 143-145
127. Doing K.M., Jerkofsky M.A., Dow E.G., and Jellison J.A. Use of fluorescent-antibody staining of cytocentrifuge-prepared smears in combination with cell culture for direct detection of respiratory viruses. J. Clin. Microbiol. 36 (1998) 2112-2114
128. Landry M.L., and Ferguson D. Simulfluor respiratory screen for rapid detection of multiple respiratory viruses in clinical specimens by immunofluorescence staining. J. Clin. Microbiol. 38 (2000) 708-711
129. Dunn J.J., Woolstenhulme R.D., Langer J., and Carroll K.C. Sensitivity of respiratory virus culture when screening with R-mix fresh cells. J. Clin. Microbiol. 42 (2004) 79-82
130. Ribes J.A., Seabolt J.P., and Overman S.B. Performance characteristics of VIDAS and directigen respiratory syncytial virus (RSV) antigen detection assays and culture for the identification of RSV in respiratory specimens. J. Clin. Microbiol. 40 (2002) 1818-1820
131. Hindiyeh M., Goulding C., Morgan H., Kenyon B., Langer J., Fox L., et al. Evaluation of BioStar FLU OIA assay for rapid detection of influenza A and B viruses in respiratory specimens. J. Clin. Virol. 17 (2000) 119-126
132. Heermann B., Larsson C., and Zweygberg B.W. Simultaneous detection and typing of influenza viruses A and B by a nested reverse transcription-PCR: comparison to virus isolation and antigen detection by immunofluorescence and optical immunoassay (FLU OIA). J. Clin. Microbiol. 39 (2001) 134-138
133. Reina J., Padilla E., Alonso F., Ruiz De Gopegui E., Munar M., and Mari M. Evaluation of a new dot blot enzyme immunoassay (directigen flu A+B) for simultaneous and differential detection of influenza a and B virus antigens from respiratory samples. J. Clin. Microbiol. 40 (2002) 3515-3517
134. Chan K.H., Maldeis N., Pope W., Yup A., Ozinskas A., Gill J., et al. Evaluation of the Directigen Flu A+B test for rapid diagnosis of influenza virus type A and B infections. J. Clin. Microbiol. 40 (2002) 1675-1680
135. Landry M.L., and Ferguson D. Suboptimal detection of influenza virus in adults by the Directigen Flu A+B enzyme immunoassay and correlation of results with the number of antigen-positive cells detected by cytospin immunofluorescence. J. Clin. Microbiol. 41 (2003) 3407-3409
136. ® and Directigen for rapid detection of influenza A and B. J. Clin. Virol. 31 (2004) 113-115
137. Murdoch D.R. Molecular genetic methods in the diagnosis of lower respiratory tract infections. APMIS 112 (2004) 713-727
138. Johnston S.L., Sanderson G., Pattemore P.K., Smith S., Bardin P.G., Bruce C.B., et al. Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J. Clin. Microbiol. 31 (1993) 111-117
139. Paton A.W., Paton J.C., Lawrence A.J., Goldwater P.N., and Harris R.J. Rapid detection of respiratory syncytial virus in nasopharyngeal aspirates by reverse transcription and polymerase chain reaction amplification. J. Clin. Microbiol. 30 (1992) 901-904
140. Falsey A.R., Formica M.A., and Walsh E.E. Diagnosis of respiratory syncitial virus infection: Comparison of reverse transcription-PCR to viral culture and serology in adults with respiratory illness. J. Clin. Microbiol. 40 (2002) 817-820
141. Claas E.C., van Milaan A.J., Sprenger M.J., Ruiten-Stuiver M., Arron G.I., Rothbarth P.H., et al. Prospective application of reverse transcriptase polymerase chain reaction for diagnosing influenza infections in respiratory samples from a children's hospital. J. Clin. Microbiol. 31 (1993) 2218-2221
142. Atmar R.L., Baxter B.D., Dominguez E.A., and Taber L.H. Comparison of reverse transcription-PCR with tissue culture and other rapid diagnostic assays for detection of type A influenza virus. J. Clin. Microbiol. 34 (1996) 2604-2606
143. Steininger C., Kundi M., Aberle S.W., Aberle J.H., and Popow-Kraupp T. Effectiveness of reverse transcription-PCR, virus isolation, and enzyme-linked immunosorbent assay for diagnosis of influenza A virus infection in different age groups. J. Clin. Microbiol. 40 (2002) 2051-2056
144. Habib-Bein N.F., Beckwith III W.H., Mayo D., and Landry M.L. Comparison of SmartCycler real-time reverse transcription-PCR assay in a public health laboratory with direct immunofluorescence and cell culture assays in a medical center for detection of influenza A virus. J. Clin. Microbiol. 41 (2003) 3597-3601
145. Hindiyeh M., Levy V., Azar R., Varsano N., Regev L., Shalev Y., et al. Evaluation of a multiplex real-time reverse transcriptase PCR assay for detection and differentiation of influenza viruses A and B during the 2001-2002 influenza season in Israel. J. Clin. Microbiol. 43 (2005) 589-595
146. Kehl S.C., Henrickson K.J., Hua W., and Fan J. Evaluation of the Hexaplex assay for detection of respiratory viruses in children. J. Clin. Microbiol. 39 (2001) 1696-1701
147. Liolios L., Jenney A., Spelman D., Kotsimbos T., Catton M., and Wesselingh S. Comparison of a multiplex reverse transcription-PCR-enzyme hybridization assay with conventional viral culture and immunofluorescence techniques for the detection of seven viral respiratory pathogens. J. Clin. Microbiol. 39 (2001) 2779-2783
148. Templeton K.E., Scheltinga S.A., Beersma M.F., Kroes A.C., and Claas E.C. Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza a and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4. J. Clin. Microbiol. 42 (2004) 1564-1569
149. Murdoch D.R. Nucleic acid amplification tests for the diagnosis of pneumonia. Clin. Infect. Dis. 36 (2003) 1162-1170
150. Falguera M., Lopez A., Nogues A., Porcel J.M., and Rubio-Caballero M. Evaluation of the polymerase chain reaction method for detection of Streptococcus pneumoniae DNA in pleural fluid samples. Chest 122 (2002) 2212-2216
151. Garcia A., Roson B., Perez J.L., Verdaguer R., Dorca J., Carratala J., et al. Usefulness of PCR and antigen latex agglutination test with samples obtained by transthoracic needle aspiration for diagnosis of pneumococcal pneumonia. J. Clin. Microbiol. 37 (1999) 709-714
152. Menendez R., Cordoba J., de La Cuadra P., Cremades M.J., Lopez-Hontagas J.L., Salavert M., et al. Value of the polymerase chain reaction assay in noninvasive respiratory samples for diagnosis of community-acquired pneumonia. Am. J. Respir. Crit. Care Med. 159 (1999) 1868-1873
153. Lorente M.L., Falguera M., Nogues A., Gonzalez A.R., Merino M.T., and Caballero M.R. Diagnosis of pneumococcal pneumonia by polymerase chain reaction (PCR) in whole blood: a prospective clinical study. Thorax 55 (2000) 133-137
154. Dominguez J., Gali N., Matas L., Pedroso P., Blanco S., Gimenez M., et al. PCR detection of Streptococcus pneumoniae DNA in serum samples for pneumococcal pneumonia diagnosis. Clin. Microbiol. Infect. 7 (2001) 164-166
155. Murdoch D.R., Anderson T.P., Beynon K.A., Chua A., Fleming A.M., Laing R.T., et al. Evaluation of a PCR assay for detection of Streptococcus pneumoniae in respiratory and nonrespiratory samples from adults with community-acquired pneumonia. J. Clin. Microbiol. 41 (2003) 63-66
156. Jonas D., Rosenbaum A., Weyrich S., and Bhakdi S. Enzyme-linked immunoassay for detection of PCR-amplified DNA of legionellae in bronchoalveolar fluid. J. Clin. Microbiol. 33 (1995) 1247-1252
157. Kenny G.E., Kaiser G.G., Cooney M.K., and Foy H.M. Diagnosis of Mycoplasma pneumoniae pneumonia: sensitivities and specificities of serology with lipid antigen and isolation of the organism on soy peptone medium for identification of infections. J. Clin. Microbiol. 28 (1990) 2087-2093
158. Boman J., Gaydos C.A., and Quinn T.C. Molecular diagnosis of Chlamydia pneumoniae infection. J. Clin. Microbiol. 37 (1999) 3791-3799
159. Verkooyen R.P., Willemse D., Hiep-van Casteren S.C., Joulandan S.A., Snijder R.J., van den Bosch J.M., et al. Evaluation of PCR, culture, and serology for diagnosis of Chlamydia pneumoniae respiratory infections. J. Clin. Microbiol. 36 (1998) 2301-2307
160. La Scola B., and Raoult D. Laboratory diagnosis of rickettsioses: current approaches to diagnosis of old and new rickettsial diseases. J. Clin. Microbiol. 35 (1997) 2715-2727
161. Fenollar F., and Raoult D. Molecular genetic methods for the diagnosis of fastidious microorganisms. APMIS 112 (2004) 785-807
162. Ogawa M., Setiyono A., Sato K., Cai Y., Shiga S., and Kishimoto T. Evaluation of PCR and nested PCR assays currently used for detection of Coxiella burnetii in Japan. Southeast Asian J. Trop. Med. Public Health 35 (2004) 852-855
163. Tong C.Y., Donnelly C., Harvey G., and Sillis M. Multiplex polymerase chain reaction for the simultaneous detection of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Chlamydia psittaci in respiratory samples. J. Clin. Pathol. 52 (1999) 257-263
164. Welti M., Jaton K., Altwegg M., Sahli R., Wenger A., and Bille J. Development of a multiplex real-time quantitative PCR assay to detect Chlamydia pneumoniae, Legionella pneumophila and Mycoplasma pneumoniae in respiratory tract secretions. Diagn. Microbiol. Infect. Dis. 45 (2003) 85-95
165. Miyashita N., Saito A., Kohno S., Yamaguchi K., Watanabe A., Oda H., et al. CAP Study Group. Multiplex PCR for the simultaneous detection of Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila in community-acquired pneumonia. Respir. Med. 98 (2004) 542-550
166. Templeton K.E., Scheltinga S.A., van den Eeden W.C., Graffelman A.W., van den Broek P.J., and Claas E.C. Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction. Clin. Infect. Dis. 41 (2005) 345-351
167. Legoff J., Guerot E., Ndjoyi-Mbiguino A., Matta M., Si-Mohamed A., Gutmann L., et al. High prevalence of respiratory viral infections in patients hospitalized in an intensive care unit for acute respiratory infections as detected by nucleic acid-based assays. J. Clin. Microbiol. 43 (2005) 455-457
168. Bryant P.A., Venter D., Robins-Browne R., and Curtis N. Chips with everything: DNA microarrays in infectious diseases. Lancet Infect. Dis. 4 (2004) 100-111
169. Soler N., Torres A., Ewig S., Gonzalez J., Celis R., El-Ebiary M., et al. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am. J. Respir. Crit. Care Med. 157 (1998) 1498-1505
170. Miravitlles M., Espinosa C., Fernandez-Laso E., Martos J.A., Maldonado J.A., and Gallego M. Relationship between bacterial flora in sputum and functional impairment in patients with acute exacerbations of COPD. Study Group of Bacterial Infection in COPD. Chest 116 (1999) 40-46
171. Ferrer M., Ioanas M., Arancibia F., Marco M.A., de la Bellacasa J.P., and Torres A. Microbial airway colonization is associated with noninvasive ventilation failure in exacerbation of chronic obstructive pulmonary disease. Crit. Care Med. 33 (2005) 2003-2009
172. Lieberman D., Lieberman D., Ben-Yaakov M., Lazarovich Z., Hoffman S., Ohana B., et al. Infectious etiologies in acute exacerbation of COPD. Diagn. Microbiol. Infect. Dis. 40 (2001) 95-102
173. Société de pneumologie de langue française. Recommandations pour la prise en charge des bronchopneumopathies chroniques obstructives. Rev. Mal. Respir. 14 Suppl 2 (1997) 1-92
174. Celli B.R., MacNee W., and ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur. Respir. J. 23 (2004) 932-946