PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway

International Immunopharmacology

Volumn 7, Issue 1, 2007, Pages 36-45

  Moon, Dong Oh ^a   Park, Cheol ^b   Heo, Moon Soo ^a   Park, Yeong Min ^c   Choi, Yung Hyun ^b   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Dong Eui University   (South Korea)

^c Pusan National University School of Medicine   (South Korea)

Author keywords

Akt; Apoptosis; Bcl 2; Caspase 3; MEK ERK; PD98059

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 3 INHIBITOR; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOLIPASE C GAMMA1; PROTEIN; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P16 INIA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL GROWTH; CELL STRAIN U937; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CASPASE 3; CELL SURVIVAL; CHROMONES; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; DOWN-REGULATION; FLAVONOIDS; G1 PHASE; HUMANS; MAP KINASE KINASE KINASES; MORPHOLINES; OLIGOPEPTIDES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; U937 CELLS;

EID: 33845214165     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2006.08.009     Document Type: Article

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