The ascochlorin derivative, AS-6, inhibits TNF-α-induced adhesion molecule and chemokine expression in rat vascular smooth muscle cells

Life Sciences

Volumn 80, Issue 2, 2006, Pages 120-126

  Park, Keun Gyu ^a   Lee, Kyeong Min ^b   Chang, Young Chae ^c   Magae, Junji ^d,e   Ando, Kunio ^e   Kim, Kwon Bae ^a   Kim, Yoon Nyun ^a   Kim, Hye Soon ^a   Park, Joong Yeol ^f   Lee, Ki Up ^f   Lee, In Kyu ^b  

^a Keimyung University School of Medicine   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

^c Catholic University of Daegu   (South Korea)

^d INSTITUTE OF RESEARCH AND INNOVATION   (Japan)

^e NRL Pharma Inc   (Japan)

^f University of Ulsan College of Medicine   (South Korea)

Author keywords

Ascochlorin 6; Atherosclerosis; CX3CL1; MCP 1; PPAR ; Vascular smooth muscle cell; VCAM 1

Indexed keywords

ASCOCHLORIN 6; CELL ADHESION MOLECULE; CHEMOKINE; FRACTALKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHENOL DERIVATIVE; PIOGLITAZONE; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ADENOVIRUS; ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; INFLAMMATION; INHIBITION KINETICS; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; VASCULAR SMOOTH MUSCLE;

ADENOVIRIDAE; ALKENES; ANIMALS; AORTA, THORACIC; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINES, CX3C; GENE EXPRESSION; GENETIC VECTORS; GLYCOLATES; LIGANDS; MALE; MEMBRANE PROTEINS; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; PHENOLS; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

ADENOVIRIDAE; RATTUS;

EID: 33845196233     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.08.030     Document Type: Article

References (30)

1. Ahn S.Y., Cho C.H., Park K.G., Lee H.J., Lee S., Park S.K., Lee I.K., and Koh G.Y. Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression. American Journal of Pathology 164 5 (2004) 1663-1672
2. Barks J.L., McQuillan J.J., and Iademarco M.F. TNF-alpha and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cells. Journal of Immunology 159 9 (1997) 4532-4538
3. Bustos C., Hernandez-Presa M.A., Ortego M., Tunon J., Ortega L., Perez F., Diaz C., Hernandez G., and Egido J. HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis. Journal of the American College of Cardiology 32 7 (1998) 2057-2064
4. Chandrasekar B., Mummidi S., Perla R.P., Bysani S., Dulin N.O., Liu F., and Melby P.C. Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. Biochemical Journal 373 Pt2 (2003) 547-558
5. Chen Y.M., Tu C.J., Hung K.Y., Wu K.D., Tsai T.J., and Hsieh B.S. Inhibition by pentoxifylline of TNF-alpha-stimulated fractalkine production in vascular smooth muscle cells: evidence for mediation by NF-kappa B down-regulation. British Journal of Pharmacology 138 5 (2003) 950-958
6. Collins T., Read M.A., Neish A.S., Whitley M.Z., Thanos D., and Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB Journal 9 10 (1995) 899-909
7. Collins A.R., Meehan W.P., Kintscher U., Jackson S., Wakino S., Noh G., Palinski W., Hsueh W.A., and Law R.E. Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice. Arteriosclerosis, Thrombosis and Vascular Biology 21 3 (2001) 365-371
8. Duval C., Chinetti G., Trottein F., Fruchart J.C., and Staels B. The role of PPARs in atherosclerosis. Trends in Molecular Medicine 8 9 (2002) 422-430
9. Dzau V.J., Braun-Dullaeus R.C., and Sedding D.G. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nature Medicine 8 11 (2002) 1249-1256
10. Forman B.M., Tontonoz P., Chen J., Brun R.P., Spiegelman B.M., and Evans R.M. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83 5 (1995) 803-812
11. Fukui Y., Masui S., Osada S., Umesono K., and Motojima K. A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes 49 5 (2000) 759-767
12. Hosokawa T., Okutomi T., Sawada M., Ando K., and Tamura G. Unusual concentration of urine and prevention of polydipsia by fungal prenylphenols in DOCA hypertensive rats. European Journal of Pharmacology 69 4 (1981) 429-438
13. Hosokawa T., Sawada M., Ando K., and Tamura G. Alteration of cholesterol metabolism by 4-O-methylascochlorin in rats. Lipids 16 6 (1981) 433-438
14. Hosokawa T., Ando K., and Tamura G. An ascochlorin derivative, AS-6 reduces insulin resistance in the genetically obese diabetic mice. Diabetes 34 3 (1985) 267-274
15. Lehmann J.M., Moore L.B., Smith-Oliver T.A., Wilkison W.O., Willson T.M., and Kliewer S.A. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). Journal of Biological Chemistry 270 22 (1995) 12953-12956
16. Li A.C., Brown K.K., Silvestre M.J., Willson T.M., Palinski W., and Glass C.K. Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. Journal of Clinical Investigation 106 4 (2000) 523-531
17. Magae J., Suzuki S., Nagai K., Yamasaki M., Ando K., and Tamura G. In vitro effects of an antitumor antibiotic, ascofuranone, on the murine immune response system. Cancer Research 46 3 (1986) 1073-1078
18. Marx N., Schonbeck U., Lazar M.A., Libby P., and Plutzky J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circulation Research 83 11 (1998) 1097-1103
19. Ollivier V., Faure S., Tarantino N., Chollet-Martin S., Deterre P., Combadiere C., and de Prost D. Fractalkine/CX3CL1 production by human aortic smooth muscle cells impairs monocyte procoagulant and inflammatory responses. Cytokine 21 6 (2003) 303-311
20. Pascual G., Fong A.L., Ogawa S., Gamliel A., Li A.C., Perissi V., Rose D.W., Willson T.M., Rosenfeld M.G., and Glass C.K. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437 7059 (2005) 759-763
21. Reginato M.J., Bailey S.T., Krakow S.L., Minami C., Ishii S., Tanaka H., and Lazar M.A. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. Journal of Biological Chemistry 273 49 (1998) 32679-32684
22. Roberts A.W., Thomas A., Rees A., and Evans M. Peroxisome proliferator-activated receptor-gamma agonists in atherosclerosis: current evidence and future directions. Current Opinion in Lipidology 14 6 (2003) 567-573
23. Ross R. The pathogenesis of atherosclerosis. A perspective for the 1990s. Nature 362 6423 (1993) 801-809
24. Spiegelman B.M. PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 47 4 (1998) 507-514
25. Tamura G., Suzuki S., Takatsuki A., Ando K., and Arima K. Ascochlorin, a new antibiotics, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlroin. (Studies on antiviral and antitumor antibiotics. I). Journal of Antibiotics 21 9 (1968) 539-544
26. Togashi M., Masuda H., Kawada T., Tanaka M., Saida K., Ando K., Tamura G., and Magae J. PPARgamma activation and adipocyte differentiation induced by AS-6, a prenyl-phenol antidiabetic antibiotic. Journal of Antibiotics 55 4 (2002) 417-422
27. Togashi M., Ozawa S., Abe S., Nishimura T., Tsuruga M., Ando K., Tamura G., Kuwahara S., Ubukata M., and Magae J. Ascochlorin derivatives as ligands for nuclear hormone receptors. Journal of Medical Chemistry 46 19 (2003) 4113-4123
28. Umehara H., Bloom E.T., Okazaki T., Nagano Y., Yoshie O., and Imai T. Fractalkine in vascular biology: from basic research to clinical disease. Arteriosclerosis, Thrombosis and Vascular Biology 24 1 (2004) 34-40
29. Wang N., Verna L., Chen N.G., Chen J., Li H., Forman B.M., and Stemerman M.B. Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells. Journal of Biological Chemistry 277 37 (2002) 34176-34181
30. Xin X., Yang S., Kowalski J., and Gerritsen M.E. Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. Journal of Biological Chemistry 274 13 (1999) 9116-9121