Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats

Biochemical Pharmacology

Volumn 73, Issue 1, 2007, Pages 155-162

  Khemawoot, Phisit ^a   Yokogawa, Koichi ^a   Shimada, Tsutomu ^a   Miyamoto, Ken ichi ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Chlorzoxazone; CYP2E1; Obesity; Zucker rat

Indexed keywords

6 HYDROXYCHLORZOXAZONE; CHLORZOXAZONE; CYTOCHROME P450 2E1; DRUG METABOLITE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG LIVER LEVEL; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; GENETIC PARAMETERS; KIDNEY; LIPID DIET; LIPOPHILICITY; MALE; MICROSOME; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; RAT STRAIN;

ANIMALS; AREA UNDER CURVE; BASE SEQUENCE; CHLORZOXAZONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2E1; DNA PRIMERS; MALE; MUSCLE RELAXANTS, CENTRAL; OBESITY; RATS; RATS, ZUCKER; RNA, MESSENGER;

EID: 33845193881     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.09.006     Document Type: Article

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