Dendritic cells amplify T cell-mediated immune responses in the central nervous system

Journal of Immunology

Volumn 177, Issue 11, 2006, Pages 7750-7760

  Karman, Jozsef ^a,c   Chu, Hamlet H ^a   Co, Dominic O ^a   Seroogy, Christine M ^b   Sandor, Matyas ^a   Fabry, Zsuzsanna ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE TRANSFER; ANTIGEN SPECIFICITY; ARTICLE; CELL INFILTRATION; CELL INVASION; CELLULAR IMMUNITY; DENDRITIC CELL; GENETIC RECOMBINATION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRAIN DIFFERENCE; TRANSGENIC ANIMAL;

EID: 33751562439     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.11.7750     Document Type: Article

References (42)

1. Hickey, W. F., B. L. Hsu, and H. Kimura. 1991. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28: 254-260.
2. Hickey, W. F. 2001. Basic principles of immunological surveillance of the normal central nervous system. Glia 36: 118-124.
3. Slavin, A. J., J. M. Soos, O. Stuve, J. C. Patarroyo, H. L. Weiner, A. Fontana, E. K. Bikoff, and S. S. Zamvil. 2001. Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity. J. Clin. Invest. 108: 1133-1139.
4. Greter, M., F. L. Heppner, M. P. Lemos, B. M. Odermatt, N. Goebels, T. Laufer, R. J. Noelle, and B. Becher. 2005. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat. Med. 11: 328-334.
5. Tompkins, S. M., J. Padilla, M. C. Dal Canto, J. P. Ting, L. Van Kaer, and S. D. Miller. 2002. De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J. Immunol. 168: 4173-4183.
6. McMahon, E. J., S. L. Bailey, C. V. Castenada, H. Waldner, and S. D. Miller. 2005. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat. Med. 11: 335-339.
7. Serot, J. M., M. C. Bene, B. Foliguet, and G. C. Faure. 2000. Monocyte-derived IL-10-secreting dendritic cells in choroid plexus epithelium. J Neuroimmunol. 105: 115-119.
8. McMenamin, P. G. 1999. Distribution and phenotype of dendritic cells and resident tissue macrophages ia the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in whole mount preparations. J. Comp. Neurol. 405: 553-562.
9. Pashenkov, M., Y. M. Huang, V. Kostulas, M. Haglund, M. Soderstrom, and H. Link. 2001. Two subsets of dendritic cells are present in human cerebrospinal fluid. Brain 124: 480-492.
10. +) blood dendritic cells in multiple sclerosis and acute optic neuritis. Clin. Exp. Immunol. 127: 519-526.
11. Fischer, H. G., U. Bonifas, and G. Reichmann. 2000. Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii. J. Immunol. 164: 4826-4834.
12. Fischer, H. G., and G. Reichmann. 2001. Brain dendritic cells and macrophages/microglia in central nervous system inflammation. J. Immunol. 166: 2717-2726.
13. Fischer, H. G., and A. K. Bielinsky. 1999. Antigen presentation function of brain-derived dendriform cells depends on astrocyte help. Int. Immunol. 11: 1265-1274.
14. Reichmann, G., M. Schroeter, S. Jander, and H. G. Fischer. 2002. Dendritic cells and dendritic-like microglia in focal cortical ischemia of the mouse brain. J. Neuroimmunol. 129: 125-132.
15. Serafini, B., S. Columba-Cabezas, F. Di Rosa, and F. Aloisi. 2000. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis. Am. J. Pathol. 157: 1991-2002.
16. Suter, T., G. Biollaz, D. Gatto, L. Bernasconi, T. Herren, W. Reith, and A. Fontana. 2003. The brain as an immune privileged site: dendritic cells of the central nervous system inhibit T cell activation. Eur. J. Immunol. 33: 2998-3006.
17. Hatterer, E., N. Davoust, M. Didier-Bazes, C. Vuaillat, C. Malcus, M. F. Belin, and S. Nataf. 2005. How to drain without lymphatics: dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 107: 806-812.
18. Karman, J., C. Ling, M. Sandor, and Z. Fabry. 2004. Initiation of immune responses in brain is promoted by local dendritic cells. J. Immunol. 173: 2353-2361.
19. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176: 1091-1098.
20. Sant'Angelo, D. B., G. Waterbury, P. Preston-Hurlburt, S. T. Yoon, R. Medzhitov, S. C. Hong, and C. A. Janeway, Jr. 1996. The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4: 367-376.
21. + T cells. J. Exp. Med. 179: 1539-1549.
22. Costa, G. L., J. M. Benson, C. M. Seroogy, P. Achacoso, C. G. Fathman, and G. P. Nolan. 2000. Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease. J. Immunol. 164: 3581-3590.
23. + regulatory T cells. Nat. Immunol. 4: 330-336.
24. Giulietti, A., L. Overbergh, D. Valckx, B. Decallonne, R. Bouillon, and C. Mathieu. 2001. An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods 25: 386-401.
25. Brummelkamp, T. R., R. Bernards, and R. Agami. 2002. A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553.
26. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
27. Kedl, R. M., J. W. Kappler, and P. Marrack. 2003. Epitope dominance, competition and T cell affinity maturation. Curr. Opin. Immunol. 15: 120-127.
28. von Herrath, M. G., R. S. Fujinami, and J. L. Whitton. 2003. Microorganisms and autoimmunity: making the barren field fertile? Nat. Rev. Microbiol. 1: 151-157.
29. Christen, U., and M. G. von Herrath. 2004. Initiation of autoimmunity. Curr. Opin. Immunol. 16: 759-767.
30. Vanderlugt, C. L., and S. D. Miller. 2002. Epitope spreading in immune-mediated diseases: implications for immunotherapy. Nat. Rev. Immunol. 2: 85-95.
31. al-Sabbagh, A., A. Miller, L. M. Santos, and H. L. Weiner. 1994. Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur. J. Immunol. 24: 2104-2109.
32. Leadbetter, E. A., C. R. Bourque, B. Devaux, C. D. Olson, G. H. Sunshine, S. Hirani, B. P. Wallner, D. E. Smilek, and M. P. Happ. 1998. Experimental autoimmune encephalomyelitis induced with a combination of myelin basic protein and myelin oligodendrocyte glycoprotein is ameliorated by administration of a single myelin basic protein peptide. J. Immunol. 161: 504-512.
33. + T cells of different antigen/MHC specificity. J. Immunol. 171: 240-246.
34. + T cells within dendritic cell clusters. Eur. J. Immunol. 33: 1686-1696.
35. Gerloni, M., S. Xiong, S. Mukerjee, S. P. Schoenberger, M. Croft, and M. Zanetti. 2000. Functional cooperation between T helper cell determinants. Proc. Natl. Acad. Sci. USA 97: 13269-13274.
36. Dong, Y., and E. N. Benveniste. 2001. Immune function of astrocytes. Glia 36: 180-190.
37. Carpentier, P. A., W. S. Begolka, J. K. Olson, A. Elhofy, W. J. Karpus, and S. D. Miller. 2005. Differential activation of astrocytes by innate and adaptive immune stimuli. Glia 49: 360-374.
38. Kort, J. J., K. Kawamura, L. Fugger, R. Weissert, and T. G. Forsthuber. 2006. Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice. J. Neuroimmunol. 173: 23-34.
39. + T-helper and a T-killer cell. Nature 393: 474-478.
40. Parker, D. C. 1993. T cell-dependent B cell activation. Annu. Rev. Immunol. 11: 331-360.
41. Alpan, O., E. Bachelder, E. Isil, H. Arnheiter, and P. Matzinger. 2004. "Educated" dendritic cells act as messengers from memory to naive T helper cells. Nat. Immunol. 5: 615-622.
42. Grewal, I. S., H. G. Foellmer, K. D. Grewal, J. Xu, F. Hardardottir, J. L. Baron, C. A. Janeway, Jr., and R. A. Flavell. 1996. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science 273: 1864-1867.