Associations of body size at birth with late-life cortisol concentrations and glucose tolerance are modified by haplotypes of the glucocorticoid receptor gene

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 11, 2006, Pages 4544-4551

  Rautanen, Anna ^a,b   Eriksson, Johan G ^a,b   Kere, Juha ^a,c   Andersson, Sture ^d   Osmond, Clive ^e   Tienari, Pentti ^a   Sairanen, Heikki ^d   Barker, David J P ^e   Phillips, David I W ^e   Forsén, Tom ^b   Kajantie, Eero ^b,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MESSENGER RNA; TRANSCORTIN;

ARTICLE; BODY HEIGHT; BODY SIZE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GLUCOSE TOLERANCE; HAPLOTYPE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMPAIRED GLUCOSE TOLERANCE; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; NEWBORN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SALIVATION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 33751536075     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-1065     Document Type: Article

References (46)

1. Barker DJP, Osmond C, Winter PD, Margetts B, Simmonds SJ 1989 Weight in infancy and death from ischaemic heart disease. Lancet 2:577-580
2. Barker DJP, Osmond C, Forsén T, Kajantie E, Eriksson JG 2005 Trajectories of growth among children who later have coronary events. N Engl J Med 353:1802-1809
3. Lithell HO, McKeigue PM, Berglund L, Moshem R, Lithell UB, Leon DA 1996 Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years. BMJ 312:406-410
4. Eriksson JG, Forsen T, Tuomilehto J, Jaddoe VW, Osmond C, Barker DJ 2002 Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals. Diabetologia 45:342-348
5. Levitt NS, Lindsay RS, Holmes MC, Seckl JR 1996 Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology 64:412-418
6. Nyirenda MJ, Lindsay RS, Kenyon CJ, Burchell A, Seckl JR 1998 Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest 101:2174-2181
7. Phillips DI, Walker BR, Reynolds RM, Flanagan DE, Wood PJ, Osmond C, Barker DJ, Whorwood CB 2000 Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations. Hypertension 35:1301-1306
8. Reynolds RM, Walker BR, Syddall HE, Andrew R, Wood PJ, Phillips DI 2005 Is there a gender difference in the associations of birthweight and adult hypothalamic-pituitary-adrenal axis activity? Eur J Endocrinol 152:249-253
9. Kajantie E, Phillips DI, Andersson S, Barker DJ, Dunkel L, Forsen T, Osmond C, Tuominen J, Wood PJ, Eriksson J 2002 Size at birth, gestational age and cortisol secretion in adult life: foetal programming of both hyper- and hypocortisolism? Clin Endocrinol (Oxf) 57:635-641
10. Kajantie E, Eriksson J, Barker DJ, Forsen T, Osmond C, Wood PJ, Andersson S, Dunkel L, Phillips DI 2003 Birth size, gestational age and adrenal function in adult life: studies of dexamethasone suppression and ACTH1-24 stimulation. Eur J Endocrinol 149:569-575
11. Kajantie E, Eriksson J, Osmond C, Wood PJ, Forsen T, Barker DJ, Phillips DI 2004 Size at birth, the metabolic syndrome and 24-h salivary cortisol profile. Clin Endocrinol (Oxf) 60:201-207
12. Ward AM, Syddall HE, Wood PJ, Chrousos GP, Phillips DI 2004 Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis: low birth weight and central HPA regulation. J Clin Endocrinol Metab 89:1227-1233
13. Welberg LA, Seckl JR 2001 Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol 13:113-128
14. Kaprio J, Tuomilehto J, Koskenvuo M, Romanov K, Reunanen A, Eriksson J, Stengard J, Kesaniemi YA 1992 Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 35:1060-1067
15. Clausson B, Lichtenstein P, Cnattingius S 2000 Genetic influence on birthweight and gestational length determined by studies in offspring of twins. BJOG 107:375-381
16. Huizenga NA, Koper JW, De Lange P, Pols HA, Stolk RP, Burger H, Grobbee DE, Brinkmann AO, De Jong FH, Lamberts SW 1998 A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab 83:144-151
17. van Rossum EF, Koper JW, van den Beld AW, Uitterlinden AG, Arp P, Ester W, Janssen JA, Brinkmann AO, de Jong FH, Grobbee DE, Pols HA, Lamberts SW 2003 Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol (Oxf) 59:585-592
18. van Rossum EF, Koper JW, Huizenga NA, Uitterlinden AG, Janssen JA, Brinkmann AO, Grobbee DE, de Jong FH, van Duyn CM, Pols HA, Lamberts SW 2002 A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes 51:3128-3134
19. van Rossum EF, Feelders RA, van den Beld AW, Uitterlinden AG, Janssen JA, Ester W, Brinkmann AO, Grobbee DE, de Jong FH, Pols HA, Koper JW, Lamberts SW 2004 Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. Am J Med 117:158-162
20. Wüst S, Van Rossum EF, Federenko IS, Koper JW, Kumsta R, Hellhammer DH 2004 Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J Clin Endocrinol Metab 89:565-573
21. Lin RC, Wang XL, Dalziel B, Caterson ID, Morris BJ 2003 Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant. Obes Res 11:802-808
22. Dobson MG, Redfern CP, Unwin N, Weaver JU 2001 The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus. J Clin Endocrinol Metab 86:2270-2274
23. Echwald SM, Sorensen TI, Andersen T, Pedersen O 2001 The Asn363Ser variant of the glucocorticoid receptor gene is not associated with obesity or weight gain in Danish men. Int J Obes Relat Metab Disord 25:1563-1565
24. Rosmond R, Bouchard C, Bjorntorp P 2001 Tsp509I polymorphism in exon 2 of the glucocorticoid receptor gene in relation to obesity and cortisol secretion: cohort study. BMJ 322:652-653
25. Marti A, Ochoa MC, Sanchez-Villegas A, Martinez JA, Martinez-Gonzalez MA, Hebebrand J, Hinney A, Vedder H 2006 Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity. BMC Med Genet 7:50
26. Rosmond R, Chagnon YC, Holm G, Chagnon M, Perusse L, Lindell K, Carlsson B, Bouchard C, Björntorp P 2000 A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis. Obes Res 8:211-218
27. Panarelli M, Holloway CD, Fraser R, Connell JM, Ingram MC, Anderson NH, Kenyon CJ 1998 Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects. J Clin Endocrinol Metab 83:1846-1852
28. Koper JW, Stolk RP, de Lange P, Huizenga NA, Molijn GJ, Pols HA, Grobbee DE, Karl M, de Jong FH, Brinkmann AO, Lamberts SW 1997 Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance. Hum Genet 99:663-668
29. Alberti KG, Zimmet PZ 1998 Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539-553
30. American Diabetes Association 2006 Diagnosis and classification of diabetes mellitus. Diabetes Care 29:S43-S48
31. Hiltunen L 2005 Ten year mortality and glucose tolerance status in an elderly Finnish population. Diabet Res Clin Pract 69:81-87
32. Kajantie E, Rautanen A, Kere J, Andersson S, Yliharsila H, Osmond C, Barker DJ, Forsen T, Eriksson J 2004 The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weight. J Clin Endocrinol Metab 89:5738-5741
33. Rautanen A, Zucchelli M, Makela S, Kere J 2005 Gene mapping with pooled samples on three genotyping platforms. Mol Cell Probes 19:408-416
34. Stevens A, Ray DW, Zeggini E, John S, Richards HL, Griffiths CE, Donn R 2004 Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype. J Clin Endocrinol Metab 89:892-897
35. Gillman MW 2005 Developmental origins of health and disease. N Engl J Med 353:1848-1850
36. Hattersley AT, Tooke JE 1999 The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular disease. Lancet 353:1789-1792
37. Kubaszek A, Markkanen A, Eriksson JG, Forsen T, Osmond C, Barker DJ, Laakso M 2004 The association of the K121Q polymorphism of the plasma cell glycoprotein-1 gene with type 2 diabetes and hypertension depends on size at birth. J Clin Endocrinol Metab 89:2044-2047
38. Lee YM, Fujiwara J, Munakata Y, Ishii T, Sugawara A, Kaku M, Kokubun S, Sasaki T, Funato T 2004 A mutation of the glucocorticoid receptor gene in patients with systemic lupus erythematosus. Tohoku J Exp Med 203:69-76
39. Pepin MC, Pothier F, Barden N 1992 Impaired type II glucocorticoid- receptor function in mice bearing antisense RNA transgene. Nature 355:725-728
40. Zhou J, Cidlowski JA 2005 The human glucocorticoid receptor: one gene, multiple proteins and diverse responses. Steroids 70:407-417
41. Meijer OC, de Lange EC, Breimer DD, de Boer AG, Workel JO, de Kloet ER 1998 Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology 139:1789-1793
42. Perley M, Kipris DM 1964 Effect of glucocorticoids on plasma insulin. N Engl J Med 274:1237-1241
43. Pagano G, Cavallo-Perin P, Cassader M, Bruno A, Ozzello A, Masciola P, Dall'omo AM, Imbimbo B 1983 An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects. J Clin Invest 72:1814-1820
44. Newell-Price J, Trainer P, Besser M, Grossman A 1998 The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states. Endocr Rev 19:647-672
45. Phillips DIW, Barker DJP, Fall CHD, Seckl JR, Whorwood CB, Wood PJ, Walker BR 1998 Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome? J Clin Endocrinol Metab 83:757-760
46. Björntorp P, Rosmond R 1999 Hypothalamic origin of the metabolic syndrome X. Ann NY Acad Sci 892:297-307