Repeated 28-day oral toxicity study of ketoconazole in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects

Archives of Toxicology

Volumn 80, Issue 12, 2006, Pages 797-803

  Shin, Jae Ho ^a   Moon, Hyun Ju ^a   Kang, Il Hyun ^a   Kim, Tae Sung ^a   Kim, In Young ^a   Park, In Sook ^a   Kim, Hyung Sik ^b   Jeung, Eui Bae ^c   Han, Soon Young ^a  

^a Korea Food and Drug Administration   (South Korea)

^b Pusan National University   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

Endocrine disruptors; Enhanced OECD Test Guideline 407; Ketoconazole; Rat

Indexed keywords

ENDOCRINE DISRUPTOR; ESTRADIOL; FOLLITROPIN; KETOCONAZOLE; LIOTHYRONINE; LUTEINIZING HORMONE; TESTOSTERONE; THYROXINE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EPIDIDYMIS; ESTRADIOL BLOOD LEVEL; ESTRUS CYCLE; FEMALE; FOLLITROPIN BLOOD LEVEL; HISTOPATHOLOGY; LIOTHYRONINE BLOOD LEVEL; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEMEN ANALYSIS; SEMINIFEROUS TUBULE; SPERMATID; TESTOSTERONE BLOOD LEVEL; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMALS; ANTIFUNGAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; ENDOCRINE SYSTEM; EPIDIDYMIS; ESTRADIOL; ESTROUS CYCLE; FEMALE; FOLLICLE STIMULATING HORMONE; GUIDELINES; KETOCONAZOLE; LUTEINIZING HORMONE; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEMINIFEROUS TUBULES; SPERMATOGENESIS; TESTOSTERONE; THYROID HORMONES; TIME FACTORS; TOXICITY TESTS;

EID: 33751513412     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0116-y     Document Type: Article

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