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Volumn 76, Issue 4, 2002, Pages 194-202
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Sensitive detection of the endocrine effects of the estrogen analogue ethinylestradiol using a modified enhanced subacute rat study protocol (OECD Test Guideline no. 407)
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Author keywords
Detection of endocrine effects; Estrogenicity; Ethinylestradiol; Modified enhanced OECD Test Guideline no. 407; Subacute rodent toxicity study
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Indexed keywords
ESTRADIOL DERIVATIVE;
ETHINYLESTRADIOL;
THYROID HORMONE;
ALKALINE PHOSPHATASE;
CYTOCHROME P450 2C11;
ESTROGEN DERIVATIVE;
LIOTHYRONINE;
LIVER ENZYME;
THYROTROPIN;
THYROXINE;
TRIACYLGLYCEROL;
ANIMAL;
ARTICLE;
BLOOD;
COMPARATIVE STUDY;
DRUG EFFECT;
DRUG SURVEILLANCE PROGRAM;
ENDOCRINE SYSTEM;
ENZYMOLOGY;
ESTRUS CYCLE;
FEMALE;
LIVER;
MALE;
MAXIMUM TOLERATED DOSE;
METABOLISM;
ORGAN SIZE;
PATHOLOGY;
RAT;
SEMINAL VESICLE;
SPERMATOZOON;
WISTAR RAT;
ADRENAL CELL;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANIMAL TISSUE;
ATROPHY;
AUTOPSY;
BEHAVIOR;
BLOOD CLOTTING TIME;
CELL COUNT;
CELL VACUOLE;
CONTROLLED STUDY;
DIESTRUS;
DOSE RESPONSE;
DRUG MEGADOSE;
ENDOCRINE DISEASE;
ENZYME ACTIVITY;
ESTROGEN ACTIVITY;
GENITAL SYSTEM;
HISTOPATHOLOGY;
HORMONE DETERMINATION;
LEYDIG CELL;
MORTALITY;
NONHUMAN;
ORGAN WEIGHT;
PRACTICE GUIDELINE;
PRIORITY JOURNAL;
SEMEN ANALYSIS;
SPERMATOZOON COUNT;
TESTIS ATROPHY;
TOXICITY;
TRIACYLGLYCEROL BLOOD LEVEL;
WEIGHT GAIN;
ZONA FASCICULATA;
ANIMALS;
ENDOCRINE SYSTEM;
ESTRADIOL CONGENERS;
ESTROUS CYCLE;
ETHINYL ESTRADIOL;
FEMALE;
LIVER;
MALE;
MAXIMUM TOLERATED DOSE;
NO-OBSERVED-ADVERSE-EFFECT LEVEL;
ORGAN SIZE;
RATS;
RATS, WISTAR;
SEMINAL VESICLES;
SPERMATOZOA;
THYROID HORMONES;
ANIMAL;
COMPARATIVE STUDY;
ESTROGENS, SYNTHETIC;
ORGAN WEIGHT;
SUPPORT, NON-U.S. GOV'T;
ANIMALIA;
RATTUS NORVEGICUS;
RODENTIA;
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EID: 0035987060
PISSN: 03405761
EISSN: None
Source Type: Journal
DOI: 10.1007/s00204-002-0337-7 Document Type: Article |
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Times cited : (52)
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References (32)
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