17α-Methyltestosterone: 28-Day oral toxicity study in the rat based on the "Enhanced OECD Test Guideline 407" to detect endocrine effects

Toxicology

Volumn 192, Issue 2-3, 2003, Pages 119-137

  Wason, Sheila ^a   Pohlmeyer Esch, Gabriele ^a   Pallen, Catherine ^a   Palazzi, Xavier ^a   Espuña, Gemma ^a   Bars, Remi ^a  

^a BAYER AG   (Germany)

Author keywords

17 Methyltestosterone; Androgen agonist; Apoptosis; Endocrine disruptors; Enhanced OECD Test Guideline 407; Rat

Indexed keywords

ESTRADIOL; LUTEINIZING HORMONE; METHYLTESTOSTERONE; TESTOSTERONE; ANDROGEN RECEPTOR; THYROTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENDOCRINE DISEASE; ESTRADIOL BLOOD LEVEL; FEMALE; GERM CELL; HISTOPATHOLOGY; HORMONE ACTION; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SPERMATOGENESIS; TESTOSTERONE BLOOD LEVEL; TOXICITY TESTING; VALIDATION PROCESS; ANIMAL; BLOOD; BODY WEIGHT; DRUG POTENTIATION; ESTRUS CYCLE; GENITAL SYSTEM; METHODOLOGY; ORAL DRUG ADMINISTRATION; ORGAN SIZE; PATHOLOGY; SPERMATOZOON COUNT; WISTAR RAT;

RATTUS NORVEGICUS;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROUS CYCLE; FEMALE; GENITALIA; MALE; METHYLTESTOSTERONE; ORGAN SIZE; RATS; RATS, WISTAR; RECEPTORS, ANDROGEN; SPERM COUNT; THYROTROPIN; TOXICITY TESTS, CHRONIC;

EID: 0142157495     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(03)00265-8     Document Type: Article

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