Abnormal expression of the peptide transporter PepT1 in the colon of massive bowel resection rat: A potential route for colonic mucosa damage by transport of fMLP

Digestive Diseases and Sciences

Volumn 51, Issue 11, 2006, Pages 2087-2093

  Shi, Bin ^a   Song, Desheng ^a   Xue, Hua ^a   Li, JinHai ^a   Li, Ning ^a,b   Li, Jieshou ^a  

^a NANJING UNIVERSITY   (China)

^b JINLING HOSPITAL   (China)

Author keywords

Bowel resection; Colon inflammation; Colonic PepT1; Di tripeptide; fMLP; Rat

Indexed keywords

CEFALEXIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; MYELOPEROXIDASE; PEPTIDE TRANSPORTER 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLITIS; COLON ABSORPTION; COLON ANASTOMOSIS; COLON INJURY; COLON MUCOSA; COLON RESECTION; CONTROLLED STUDY; ENZYME ACTIVITY; INTESTINE PERFUSION; INTESTINE WALL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMALL INTESTINE RESECTION; TRANSPORT KINETICS; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CEPHALEXIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLON; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; SYMPORTERS;

EID: 33751512540     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-9067-z     Document Type: Article

References (33)

1. Adibi SA (2003) Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease. Am J Physiol Gastrointest Liver Physiol 285:G779-G788
2. Rubio-Aliaga I, Daniel H (2002) Mammalian peptide transporters as targets for drug delivery. Trends Pharmacol Sci 23:434-440
3. Xiao-Yan Chu, Gloria P, Anchez-Castano S, Kazutaka Higaki, Doo-Man OH, Cheng-Pang Hsu, Gordon L (2001) Amidon. Correlation between epithelial cell permeability of cephalexin and expression of intestinal oligopeptide transporter. J PET 299:575-582
4. Buyse M, Tsocas A, Walker F, Merlin D, Bado A (2002) PepT1-mediated fMLP transport induces intestinal inflammation in vivo. Am J Physiol Cell Physiol 283:C1795-C1800
5. Chadwick VS, Mellor DM, Myers DB, Seldon AC, Keshavarzian MF, Hobson CH (1988) Production of peptides inducing chemotaxis and lysosomal enzyme release in human neutrophils by intestinal bacteria in vitro and in vivo. Scand J Gastroenterol 23:121-128
6. Painter RG, Sklar LA, Jesaitis AJ, Schmitt M, Cochrane CG (1984) Activation of neutrophils by N-formyl chemotactic peptides. Fed Proc 43:2737-2742
7. Marasco WA, Phan SH, Krutzsch H, Showell HJ, Feltner DE, Nairn R, Becker EL, Ward PA (1984) Purification and identification of formyl-methionyl-leucyl- phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J Biol Chem 259:5430-5439
8. Merlin D, Steel A, Gewirtz AT, Si-Tahar M, Hediger MA, Madara JL (1998) hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions. J Clin Invest 102:2011-2018
9. Merlin D, Si-Tahar M, Sitaraman SV, Eastburn K, Williams I, Liu X, Hediger MA, Madara JL (2001) Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: transport of bacterial peptides influences expression of MHC class 1 molecules. Gastroenterology 120:1666-1679
10. Fei Y-J, Kanai Y, Nussberger S, Ganapathy V, Leibach FH, Romero MF, Singh SK, Boron WF, Hediger MA (1994) Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 368:563-566
11. +/peptide cotransporter. Cloning, functional expression and chromosomal localization. J Biol Chem 270:6456-6463
12. +/peptide cotransporter mediating absorption of β-lactam antibiotics in the intestine and kidney. J Pharmacol Exp Ther 275:1631-1637
13. +/di-tripeptide transporter (PepT1) expression in the rabbit intestine. Eur J Physiol 430:394-400
14. Ford D, Howard A, Hirst BH (2003) Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption. Histochem Cell Biol 119:37-43
15. Christoph von Ritter, Sekizuka E, Grisham MB, Granger DN (1988) The chemotactic N-formyl-methionyl-leucylphenylalanine peptide increases mucosal permeability in the distal ileum of the rat. Gastroenterology 95:651-656
16. Rome S, Barbot L, Windsor E, Kapel N, Tricottet V, Huneau JF, Reynes M, Gobert JG, Tomé D (2002) The regionalization of PepT1, NBAT and EAAC1 transporters in the small intestine of rats are unchanged from birth to adulthood. J Nutr 132:1009-1011
17. Tanaka H, Miyamoto KI, Morita K, Haga H, Segawa H, Shiraga T, Fujioka A, Kouda T, Taketani Y, Hisano S, Fukui Y, Kitagawa K, Takeda E (1998) Regulation of the PepT1 peptide transporter in the rat small intestine in response to 5-fluorouracil-induced injury. Gastroenterology 114:714-723
18. Akarawut W, Lin C-J, Smith DE (1998) Noncompetitive inhibition of glycylsarcosine transport by quinapril in rabbit renal brush border membrane vesicles: effect on high-affinity peptide transporter. J Pharmacol Exp Ther 287:684-690
19. Hong S, Smith DE, Brosius FC III (2001) Developmental expression of PEPT1 and PEPT2 in rat small intestine, colon, and kidney. Pediatr Res 49:789-795
20. Brosius FC III, Liu Y, Nguyen N, Sun D, Bartlett J, Schwaiger M (1997) Persistent myocardial ischemia increases GLUT1 glucose transporter expression in both ischemic and nonischemic heart regions. J Mol Cell Cardiol 29:1675-1685
21. Hong S, Smith DE, Yang T, Huang YG, Schnermann JB, Brosius FC III (1999) Localization of PEPT1 and PEPT2 proton-coupled oligopeptide transporter mRNA and protein in rat kidney. Am J Physiol 276(Renal Physiol 45):F658-F665
22. +/peptide transporter PepT1 in human intestine: upregulated expression in the colonic mucosa of patients with short-bowel syndrome. Am J Clin Nutr 75:922-930
23. Hu M, Amidon GL (1988) Passive and carrier-mediated intestinal absorption components of captopril. J Pharm Sci 77:1007-1011
24. Gangopadhyay A, Thamotharan M, Adibi SA (2002) Regulation of oligopeptide transporter (Pept-1) in experimental diabetes. Am J Physiol Gastrointest Liver Physiol 283:G133-G138
25. Barbot L, Windsor E, Rome S, Tricottet V, Reynes M, Topouchian A, Huneau JF, Gobert JG, Tome D, Kapel N (2003) Intestinal peptide transporter PepT1 is over-expressed during acute cryptosporidiosis in suckling rats as a result of both malnutrition and experimental parasite infection. Parasitol Res 89:364-370
26. Curtis KJ, Kim JM, Perdomo JM, Silk DB, Whitehead JS (1978) Protein digestion and absorption in the rat. J Physiol 274:409-419
27. Fuller MF, Reeds PJ (1998) Nitrogen cycling in the gut. Annu Rev Nutr 18:385-411
28. Buyse M, Berlioz F, Guilmeau S, Tsocas A, Voisin T, Péranzi G, Merlin D, Laburthe M, Lewin MJM, Rozé C, Bado A (2001) PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine. J Clin Invest 108:1483-1494
29. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75:253-261
30. Matsuda H, Fuijama Y, Andoh A, Ushijama T, Kajinami T, Bamba T (2000) Characterisation of antibody responses against rectal mucosa-associated bacterial flora in patients with ulcerative colitis. J Gastroenterol Hepatol 15:61-68
31. Burke DA, Axon ATR (1987) Ulcerative colitis and Escherichia coli with adhesive properties. J Clin Pathol 40:782-786
32. Karlinger K, Gyorke T, Mako E, Mester A, Tarjan Z (2000) The epidemiology and the pathogenesis of inflammatory bowel disease. Eur J Radiol 35:154-167
33. Brandwein SL, McCabe RP, Cong Y, Waites KB, Ridwan BU, Dean PA, Ohkusa T, Birkenmeier EH, Sundberg JP, Elson CO (1997) Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J Immunol 159:44-52