Intestinal peptide transporter PepT1 is over-expressed during acute cryptosporidiosis in suckling rats as a result of both malnutrition and experimental parasite infection

Parasitology Research

Volumn 89, Issue 5, 2003, Pages 364-370

  Barbot, L ^a,b   Windsor, E ^a   Rome, S ^c   Tricottet, V ^a,d   Reynes M ^d   Topouchian, A ^a   Huneau, J F ^c   Gobert, J G ^a,b   Tome D ^c   Kapel, N ^a,b  

^a FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c INRA Institut National de la Recherche Agronomique   (France)

^d HÔPITAL PAUL BROUSSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; MESSENGER RNA; PEPTIDE; PEPTIDE TRANSPORTER 1; UNCLASSIFIED DRUG;

AMINO ACID DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DIET THERAPY; FEMALE; GENE OVEREXPRESSION; GROWTH RETARDATION; IMMUNOLOCALIZATION; INTESTINE BRUSH BORDER; INTESTINE CELL; MALNUTRITION; MEMBRANE DAMAGE; NEWBORN; NONHUMAN; NUTRITION; PARASITOSIS; PRIORITY JOURNAL; RAT; SMALL INTESTINE; SUCKLING; TRANSCRIPTION REGULATION;

ANIMALIA; CRYPTOSPORIDIUM; CRYPTOSPORIDIUM PARVUM; PROTOZOA;

EID: 0037350594     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-002-0776-3     Document Type: Article

References (39)

1. Adibi SA, Kim YS (1981) Peptide absorption and hydrolysis. In: Johnson LR (ed) Physiology of the gastrointestinal tract, vol 2. Raven, New York, pp 1073-1095
2. Adibi SA, Fogel MR, Agarwal RM (1974) Comparison of free amino acid and dipeptide absorption in the jejunum of sprue patients. Gastroenterology 67:586-591
3. Agnew DG, Lima AAM, Newman RD, Wuhib T, Moore RD, Guerrant RL, Sears CL (1998) Cryptosporidiosis in northeastern Brazilian children: association with increased diarrhea morbidity. J Infect Dis 177:754-760
4. + absorption in enteric cryptosporidiosis of pigs. Gastroenterology 98:1129-1140
5. Buyse M, Berlioz F, Guilmeau S, Tsocas A, Voisin T, Péranzi G, Merlin D, Laburthe M, Lewin MJM, Rozé C, Bado A (2001) PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine. J Clin Invest 108:1483-1494
6. Capet C, Kapel N, Huneau JF, Magne D, Laikuen R, Tricottet V, Benhamou Y, Tomé D, Gobert JG (1999) Cryptosporidium parvum infection in suckling rats: impairment of mucosal permeability and Na+-glucose cotransport. Exp Parasitol 91:119-125
7. Checkley W, Gilman RH, Epstein LD, Suarez M, Diaz JF, Cabrera L, Black RE, Sterling CR (1997) Asymptomatic and symptomatic cryptosporidiosis: their acute effect in weight gain in Peruvian children. Am J Epidemiol 45:156-163
8. Checkley W, Epstein LD, Gilman RH, Black RE, Cabrera L, Sterling CR (1998) Effects of Cryptosporidium parvum infection in Peruvian children: growth faltering and subsequent catch-up growth. Am J Epidemiol 148:497-506
9. Cheeseman CI (1986) Expression of amino acid and peptide transport systems in rat small intestine. Am J Physiol 251:G636-G641
10. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
11. Clark DP (1999) New insights into human cryptosporidiosis. Clin Microbiol Rev 12:554-563
12. Cruz JR, Cano F, Caceres P, Chew F, Pareja G (1988) Infection and diarrhea caused by Cryptosporidium sp. among Guatemalan infants. J Clin Microbiol 26:88-91
13. Elliott DA, Clark DP (2000) Cryptosporidium parvum induces host cell actin accumulation at the host-parasite interface. Infect Immun 68:2315-2322
14. Elliot DA, Coleman DJ, Lane MA, May RC, Machesky LM, Clark DP (2001) Cryptosporidium parvum infection requires host cell actin polymerization. Infect Immun 69:5940-5942
15. Farthing MJG (2000) Clinical aspects of human cryptosporidiosis. Contrib Microbiol 6:50-74
16. Guandalini S, Rubino A (1982) Development of dipeptide transport in the intestinal mucosa of rabbits. Pediatr Res 16:99-103
17. Guerrant DI, Moore SR, Lima AA, Patrick PD, Schorling JB, Guerrant RL (1999) Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four-seven years later in a poor urban community in northeast Brazil. Am J Trop Med Hyg 61:707-713
18. Henriksen SA, Pohlenz JF (1981) Staining of cryptosporidia by a modified Ziehl-Neelsen technique. Acta Vet Scand 22:594-596
19. Himukai M, Konno T, Hoshi T (1980) Age-dependent change in intestinal absorption of dipeptides and their constituent amino acids in the guinea pig. Pediatr Res 14:1272-1275
20. Ihara T, Tsujikawa T, Fujiyama Y, Bamba T (2000) Regulation of PepT1 peptide transporter expression in the rat small intestine under malnourished conditions. Digestion 61:59-67
21. Lee VHL (2000) Membrane transporters. Eur J Pharmaceut Sci 11 [Suppl 2]:S41-S50
22. MacFarlane DE, Horner-Bryce J (1987) Cryptosporidiosis in well nourished and malnourished children. Acta Paediatr Scand 76:474-477
23. Marcial MA, Madara JL (1986) Cryptosporidium: cellular localization, structural analysis of absorptive cell-parasite membrane-membrane interactions in guinea pigs, and suggestion of protozoan transport by M cells. Gastroenterology 90:583-594
24. Miyamoto KI, Shiraga T, Morita K, Yamamoto H, Haga H, Taketani Y, Tamai I, Sai Y, Tsuji A, Takeda E (1996) Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter. Biochim Biophys Acta 1305:34-38
25. Molbak K, Andersen M, Aaby P, Hojlyng N, Jakobsen M, Sodemann M, Da Silva AP (1997) Crystosporidium infection in infancy as a cause of malnutrition: a community study from Guinea-Bissau, West Africa. Am J Clin Nutr 65:149-152
26. Moore R, Tzipori S, Griffiths JK, Johnson K, De Montigny L, Lomakina I (1995) Temporal changes in permeability and structure of piglet ileum after site-specific infection by Cryptosporidium parvum. Gastroenterology 108:1030-1039
27. Nutzenadel W, Fahr K, Lutz P (1981) Absorption of free and peptide-linked glycine and phenylalanlne in children with active coeliac disease. Pediatr Res 15:309-312
28. O'Donoghue PJ (1995) Cryptosporidium and cryptosporidiosis in man and animals. Int J Parasitol 25:139-195
29. Ogihara H, Suzuki T, Nagamachi Y, Inui KI, Takata K (1999) Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acids. Histochem J 31:169-174
30. Rome S, Barbot L, Windsor E, Kapel N, Tricottet V, Huneau JF, Reynes M, Gobert JG, Tomé D (2002) The regionalization of PepT1, NBAT and EAAC1 transporters in the small intestine of rats are unchanged from birth to adulthood. J Nutr 132:1009-1011
31. Sallon S, Deckelbaum RJ, Schmid II, Harlap S, Baras M, Spira DT (1988) Cryptosporidium, malnutrition, and chronic diarrhea in children. Am J Dis Child 142:312-315
32. Scrimshaw NS, SanGiovanni JP (1997) Synergism of nutrition, infection, and immunity: an overview. Am J Clin Nutr 66:464S-477S
33. +/peptide transporter PepT1. Gastroenterology 116:354-362
34. Silk DB, Kumar PJ, Perrett D, Clark ML, Dawson AM (1974) Amino acid and peptide absorption in patients with coeliac disease and dermatitis herpetiformis. Gut 15:1-8
35. Tanaka H, Miyamoto KI, Morita K, Haga H, Segawa H, Shiraga T, Fujioka A, Kouda T, Taketani Y, Hisano S, Fukui Y, Kitagawa K, Takeda E (1998) Regulation of the PepT1 peptide transporter in the rat small intestine in response to 5-fluorouracil-induced injury. Gastroenterology 114:714-723
36. Thamotharan M, Bawani SZ, Zhou X, Adibi SA (1999a) Functional and molecular expression of intestinal oligopeptide transporter (PepT-1) after a brief fast. Metabolism 48:681-684
37. Thamotharan M, Bawani SZ, Zhou X, Adibi SA (1999b) Hormonal regulation of oligopeptide transporter PepT-1 in a human intestinal cell line. Am J Physiol Cell Physiol 276:C821-C826
38. Topouchian A, Kapel N, Huneau JF, Barbot L, Magne D, Tomé D, Gobert JG (2001) Impairment of amino-acid absorption in suckling rats infected with Cryptosporidium parvum. Parasitol Res 87:891-896
39. Walker D, Thwaites DT, Simmons NL, Gilbert H J, Hirst BH (1998) Substrate up-regulation of the human small intestinal peptide transporter, hPepT1. J Physiol (Lond) 507:697-706