Serotonin potentiates sympathetic responses evoked by spinal NMDA

Journal of Physiology

Volumn 577, Issue 2, 2006, Pages 525-537

  Madden, Christopher J ^a   Morrison, Shaun F ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXCITATORY AMINO ACID RECEPTOR; METHYSERGIDE; N METHYL DEXTRO ASPARTIC ACID; SEROTONIN; SEROTONIN RECEPTOR; EXCITATORY AMINO ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; HEART RATE; LATENT PERIOD; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SYMPATHETIC TONE; THERMOGENESIS; THORACIC SPINE; ADRENERGIC TRANSMISSION; ANIMAL CELL; EVOKED RESPONSE; MICROINJECTION; SPINAL CORD; SPINAL CORD NERVE CELL; SPINAL INTERMEDIOLATERAL NUCLEUS; SYMPATHETIC NERVE;

ACTION POTENTIALS; ADIPOSE TISSUE, BROWN; ANIMALS; BLOOD PRESSURE; BODY TEMPERATURE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EXCITATORY AMINO ACID AGONISTS; HEART RATE; INJECTIONS, SPINAL; MALE; METHYSERGIDE; MICROINJECTIONS; N-METHYLASPARTATE; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SEROTONIN; RESPIRATION; SEROTONIN; SEROTONIN ANTAGONISTS; SPINAL CORD; SYMPATHETIC NERVOUS SYSTEM; THERMOGENESIS;

EID: 33751313602     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.116574     Document Type: Article

References (46)

1. Baker-Herman TL, Fuller DD, Bavis RW, Zabka AG, Golder FJ, Doperalski NJ, Johnson RA, Watters JJ & Mitchell GS (2004). BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Nat Neurosci 7, 48-55.
2. Baker-Herman TL & Mitchell GS (2002). Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesis. J Neurosci 22, 6239-6246.
3. Breisch ST, Zemlan FP & Hoebel BG (1976). Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine. Science 192, 382-385.
4. Cannon B & Nedergaard J (2004). Brown adipose tissue: Function and physiological significance. Physiol Rev 84, 277-359.
5. Cano G, Passerin AM, Schiltz JC, Card JP, Morrison SF & Sved AF (2003). Anatomical substrates for the central control of sympathetic outflow to interscapular adipose tissue during cold exposure. J Comp Neurol 460, 303-326.
6. Cao WH, Fan W & Morrison SF (2004). Medullary pathways mediating specific sympathetic responses to activation of dorsomedial hypothalamus. Neuroscience 126, 229-240.
7. Cerri M & Morrison SF (2005). Activation of lateral hypothalamic neurons stimulates brown adipose tissue thermogenesis. Neuroscience 135, 627-638.
8. Coote JH, Macleod VH, Fleetwood-Walker S & Gilbey MP (1981). The response of individual sympathetic preganglionic neurones to microelectrophoretically applied endogenous monoamines. Brain Res 215, 135-145.
9. Cornea-Hebert V, Riad M, Wu C, Singh SK & Descarries L (1999). Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat. J Comp Neurol 409, 187-209.
10. De Groat WC & Ryall RW (1967). An excitatory action of 5-hydroxytryptamine on sympathetic preganglionic neurons. Exp Brain Res 3, 299-305.
11. Fuller DD, Bach KB, Baker TL, Kinkead R & Mitchell GS (2000). Long term facilitation of phrenic motor output. Respir Physiol 121, 135-146.
12. Fuller NJ, Stirling DM, Dunnett S, Reynolds GP & Ashwell M (1987). Decreased brown adipose tissue thermogenic activity following a reduction in brain serotonin by intraventricular p-chlorophenylalanine. Biosci Rep 7, 121-127.
13. Gelderd JB & Chopin SF (1977). The vertebral level of origin of spinal nerves in the rat. Anat Rec 188, 45-47.
14. Gilbey MP & Stein RD (1991). Characteristics of sympathetic preganglionic neurones in the lumbar spinal cord of the cat. J Physiol 432, 427-443.
15. Gudelsky GA, Koenig JI & Meltzer HY (1986). Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptors. Neuropharmacology 25, 1307-1313.
16. Hamann A, Flier JS & Lowell BB (1996). Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 137, 21-29.
17. Jacobs BL, Martin-Cora FJ & Fornal CA (2002). Activity of medullary serotonergic neurons in freely moving animals. Brain Res Brain Res Rev 40, 45-52.
18. Levitsky DA & Troiano R (1992). Metabolic consequences of fenfluramine for the control of body weight. Am J Clin Nutr 55, 167S-172S.
19. Lewis DI & Coote JH (1990). The influence of 5-hydroxytryptamine agonists and antagonists on identified sympathetic preganglionic neurones in the rat, in vivo. Br J Pharmacol 99, 667-672.
20. Madden CJ & Morrison SF (2003). Excitatory amino acid receptor activation in the raphe pallidus area mediates prostaglandin-evoked thermogenesis. Neuroscience 122, 5-15.
21. Madden CJ & Morrison SF (2004). Excitatory amino acid receptors in the dorsomedial hypothalamus mediate prostaglandin-evoked thermogenesis in brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 286, R320-R325.
22. Madden CJ & Morrison SF (2005). Hypoxic activation of arterial chemoreceptors inhibits sympathetic outflow to brown adipose tissue in rats. J Physiol 566, 559-573.
23. Maeshima T, Ito R, Hamada S, Senzaki K, Hamaguchi-Hamada K, Shutoh F & Okado N (1998). The cellular localization of 5-HT2A receptors in the spinal cord and spinal ganglia of the adult rat. Brain Res 797, 118-124.
24. Marina N, Taheri M & Gilbey MP (2006). Generation of a physiological sympathetic motor rhythm in the rat following spinal application of 5-HT. J Physiol 571, 441-450.
25. Marlier L, Teilhac JR, Cerruti C & Privat A (1991). Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord. Brain Res 550, 15-23.
26. Martin-Cora FJ, Fornal CA, Metzler CW & Jacobs BL (2000). Single-unit responses of serotonergic medullary and pontine raphe neurons to environmental cooling in freely moving cats. Neuroscience 98, 301-309.
27. McCall RB & Aghajanian GK (1979). Serotonergic facilitation of facial motoneuron excitation. Brain Res 169, 11-27.
28. Morrison SF (2004). Central pathways controlling brown adipose tissue thermogenesis. News Physiol Sci 19, 67-74.
29. Morrison SF, Sved AF & Passerin AM (1999). GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 276, R290-R297.
30. Myslinski NR & Anderson EG (1978). The effect of serotonin precursors on alpha- and gamma-motoneuron activity. J Pharmacol Exp Ther 204, 19-26.
31. Nakamura K, Matsumura K, Hubschle T, Nakamura Y, Hioki H, Fujiyama F, Boldogkoi Z, Konig M, Thiel HJ, Gerstberger R, Kobayashi S & Kaneko T (2004). Identification of sympathetic premotor neurons in medullary raphe regions mediating fever and other thermoregulatory functions. J Neurosci 24, 5370-5380.
32. Oberkofler H, Dallinger G, Liu YM, Hell E, Krempler F & Patsch W (1997). Uncoupling protein gene: Quantification of expression levels in adipose tissues of obese and non-obese humans. J Lipid Res 38, 2125-2133.
33. Ootsuka Y & Blessing WW (2005). Activation of slowly conducting medullary raphe-spinal neurons, including serotonergic neurons, increases cutaneous sympathetic vasomotor discharge in rabbit. Am J Physiol Regul Integr Comp Physiol 288, R909-R918.
34. Ootsuka Y & Blessing WW (2006). Thermogenesis in brown adipose tissue: Increase by 5-HT2A receptor activation and decrease by 5-HT1A receptor activation in conscious rats. Neurosci Lett 395, 170-174.
35. Passerin AM, Bellush LL & Henley WN (1999). Activation of bulbospinal serotonergic neurons during cold exposure. Can J Physiol Pharmacol 77, 250-258.
36. Passerin AM & Henley WN (1994). Activation of spinal cord serotonergic neurons accompanies cold-induced sympathoexcitation. Can J Physiol Pharmacol 72, 884-892.
37. Pickering AE, Spanswick D & Logan SD (1994). 5-Hydoxytryptamine evokes depolarizations and membrane potential oscillations in rat sympathetic preganglionic neurones. J Physiol 480, 109-121.
38. Rathner JA & Morrison SF (2006). Rostral ventromedial periaqueductal gray: A source of inhibition of the sympathetic outflow to brown adipose tissue. Brain Res 1077, 99-107.
39. Stornetta RL, Rosin DL, Simmons JR, McQuiston TJ, Vujovic N, Weston MC & Guyenet PG (2005). Coexpression of vesicular glutamate transporter-3 and γ-aminobutyric acidergic markers in rat rostral medullary raphe and intermediolateral cell column. J Comp Neurol 492, 477-494.
40. Sundaram K, Murugaian J & Sapru H (1989). Cardiac responses to the microinjections of excitatory amino acids into the intermediolateral cell column of the rat spinal cord. Brain Res 482, 12-22.
41. Tanaka M, Owens NC, Nagashima K, Kanosue K & McAllen RM (2006). Reflex activation of rat fusimotor neurons by body surface cooling, and its dependence on the medullary raphe. J Physiol 572, 569-583.
42. Thor KB, Nickolaus S & Helke CJ (1993). Autoradiographic localization of 5-hydroxytryptamine 1A, 5-hydroxytryptamine 1B and 5-hydroxytryptamine 1C/2 binding sites in the rat spinal cord. Neuroscience 55, 235-252.
43. White SR & Neuman RS (1980). Facilitation of spinal motoneurone excitability by 5-hydroxytryptamine and noradrenaline. Brain Res 188, 119-127.
44. Yuen EY, Jiang Q, Chen P, Gu Z, Feng J & Yan Z (2005). Serotonin 5-HT 1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism. J Neurosci 25, 5488-5501.
45. Zaretskaia MV, Zaretsky DV & DiMicco JA (2003). Role of the dorsomedial hypothalamus in thermogenesis and tachycardia caused by microinjection of prostaglandin E2 into the preoptic area in anesthetized rats. Neurosci Lett 340, 1-4.
46. Zaretskaia MV, Zaretsky DV, Shekhar A & DiMicco JA (2002). Chemical stimulation of the dorsomedial hypothalamus evokes non-shivering thermogenesis in anesthetized rats. Brain Res 928, 113-125.