Substrate dependence of conformational changes in the RNA-binding domain of tristetraprolin assessed by fluorescence spectroscopy of tryptophan mutants

Biochemistry

Volumn 45, Issue 46, 2006, Pages 13807-13817

  Brewer, Brandy Y ^a   Ballin, Jeff D ^a   Fialcowitz White, Elizabeth J ^a   Blackshear, Perry J ^b   Wilson, Gerald M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; CONFORMATIONS; FLUORESCENCE; RNA; SPECTROSCOPIC ANALYSIS; TITRATION;

CONFORMATIONAL CHANGES; FLUORESCENCE SPECTROSCOPY; RAPID CYTOPLASMIC DEGRADATION;

SUBSTRATES;

ADENINE; LIGAND; MESSENGER RNA; MUTANT PROTEIN; PEPTIDE; RNA BINDING PROTEIN; TRISTETRAPROLIN; TRYPTOPHAN; URACIL; ZINC FINGER PROTEIN; ZINC ION;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; AU RICH MESSENGER RNA DESTABILIZING ELEMENT; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; FLUORESCENCE SPECTROSCOPY; HUMAN; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA DEGRADATION; RNA SEQUENCE; RNA STRUCTURE; STRUCTURE ANALYSIS; THERMODYNAMICS; TRANSCRIPTION REGULATION; ZINC FINGER MOTIF;

AMINO ACID SEQUENCE; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RNA, MESSENGER; RNA-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TRISTETRAPROLIN; TRYPTOPHAN; ZINC FINGERS;

EID: 33751252012     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061320j     Document Type: Article

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