Stability of the first-generation Grubbs metathesis catalyst in a continuous flow reactor

Journal of Organometallic Chemistry

Volumn 691, Issue 24-25, 2006, Pages 5197-5203

  Lysenko, Zenon ^a   Maughon, Bob R ^a   Mokhtar Zadeh, Tezi ^a   Tulchinsky, Michael L ^a  

^a DOW CHEMICAL COMPANY   (United States)

Author keywords

Carbene; Continuous flow; Metathesis; Ruthenium; Stability

Indexed keywords

CHEMICAL BONDS; CHEMICAL REACTORS; CONCENTRATION (PROCESS); MIXTURES; RUTHENIUM COMPOUNDS; STABILITY;

CARBENE; CONTINUOUS FLOW; METATHESIS; REACTION MIXTURES;

CATALYSTS;

EID: 33751234513     PISSN: 0022328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jorganchem.2006.08.031     Document Type: Article

References (14)

1. Grubbs R.H. Tetrahedron 60 (2004) 7117-7140 and references cited therein
2. Trnka T.M., and Grubbs R.H. Acc. Chem. Res. 34 1 (2001) 18-29
3. Hong S.H., and Grubbs R.H. J. Am. Chem. Soc. 128 11 (2006) 3508-3509
4. Funk T.W., Berlin J.M., and Grubbs R.H. J. Am. Chem. Soc. 128 6 (2006) 1840-1846
5. Burdett K.A., Harris L.D., Margl P., Maughon B.R., Mokhtar-Zadeh T., Saucier P.C., and Wasserman E.P. Organometallics 23 9 (2004) 2027-2047
6. Ulman M., and Grubbs R.H. J. Org. Chem. 64 (1999) 7202-7207
7. van Rensburg W.J., Steynberg P.J., Meyer W.H., Kirk M.M., and Forman G.S. J. Am. Chem. Soc. 126 44 (2004) 14332-14333
8. Louie J., and Grubbs R.H. Organometallics 21 (2002) 2153-2164
9. Dinger M.B., and Mol J.C. Organometallics 22 (2003) 1089-1095
10. Sanford M.S., and Love J.A. In: Grubbs R. (Ed). Mechanism of Ruthenium-Catalyzed Olefin Metathesis Reactions. Handbook of Metathesis vol. 1 (2003), Wiley, New York 112-131 and references cited therein
11. For the application of a similar continuous flow reactor in hydroformylation, see this and a subsequent reference:. Selin M.F., Webb P.B., and Cole-Hamilton D.J. Chem. Commun. 8 (2001) 781-782
12. Webb P.B., Sellin M.F., Kunene T.E., Williamson S., Slawin A.M.Z., and Cole-Hamilton D.J. J. Am. Chem. Soc. 125 50 (2003) 15577-15588
13. Pangborn A.B., Giardello M.A., Grubbs R.H., Rosen R.K., and Timmers F.J. Organometallics 15 (1996) 1518-1520
14. Hong S.H., Day M.W., and Grubbs R.H. J. Am. Chem. Soc. 126 24 (2004) 7414-7415