BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility

BMC Cancer

Volumn 6, Issue , 2006, Pages

  Zheng, Xiaomin ^a   Güller, Saskia ^a   Beissert, Tim ^a   Puccetti, Elena ^a   Ruthardt, Martin ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; GUANOSINE TRIPHOSPHATASE; PROTEIN CDC42; RAC PROTEIN; RHO FACTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; CHEMOTAXIS; CHROMOSOME 22; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM CELL; ENZYME ACTIVATION; IMMUNOFLUORESCENCE; LEUKEMIA; MUTANT; NONHUMAN; PLASMID; RECIPROCAL CHROMOSOME TRANSLOCATION; REGULATORY MECHANISM; SHEAR STRESS; SPHEROID CELL; STROMA; WESTERN BLOTTING; WILD TYPE;

CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; CYTOSKELETON; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PROTO-ONCOGENE PROTEINS C-BCR; RAC GTP-BINDING PROTEINS; RHO GTP-BINDING PROTEINS; TUMOR CELLS, CULTURED;

EID: 33751165072     PISSN: 14712407     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-6-262     Document Type: Article

References (27)

1. Faderl S, Talpaz M, Estrov Z, S OB, Kurzrock R, Kantarjian HM: The biology of chronic myeloid leukemia. N Engl J Med 1999, 341:164-172.
2. Gokbuget N, Hoelzer D, Arnold R, Bohme A, Bartram CR, Freund M, Ganser A, Kneba M, Langer W, Lipp T, Ludwig WD, Maschmeyer G, Rieder H, Thiel E, Weiss A, Messerer D: Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL). Hematol Oncol Clin North Am 2000, 14:1307-25, ix..
3. Deininger M, Buchdunger E, Druker BJ: The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood 2005, 105:2640-2653.
4. Kantarjian H, Giles F, Wunderle L, Bhalla K, O'Brien S, Wassmann B, Tanaka C, Manley P, Rae P, Mietlowski W, Bochinski K, Hochhaus A, Griffin JD, Hoelzer D, Albitar M, Dugan M, Cortes J, Alland L, Ottmann OG: Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006, 354:2542-2551.
5. Tokarski JS, Newitt JA, Chang CY, Cheng JD, Wittekind M, Kiefer SE, Kish K, Lee FY, Borzillerri R, Lombardo LJ, Xie D, Zhang Y, Klei HE: The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. Cancer Res 2006, 66:5790-5797.
6. Melo JV, Gordon DE, Cross NC, Goldman JM: The ABL-BCR fusion gene is expressed in chronic myeloid leukemia. Blood 1993, 81:158-165.
7. Melo JV, Gordon DE, Tuszynski A, Dhut S, Young BD, Goldman JM: Expression of the ABL-BCR fusion gene in Philadelphia-positive acute lymphoblastic leukemia. Blood 1993, 81:2488-2491.
8. Maru Y, Witte ON: The BCR gene encodes a novel serine/threonine kinase activity within a single exon. Cell 1991, 67:459-468.
9. Mahon GM, Wang Y, Korus M, Kostenko E, Cheng L, Sun T, Arlinghaus RB, Whitehead IP: The c-Myc Oncoprotein Interacts with Bcr. Curr Biol 2003, 13:437-441.
10. Boguski MS, McCormick F: Proteins regulating Ras and its relatives. Nature 1993, 366:643-654.
11. Van Aelst L, C DSS: Rho GTPases and signaling networks. Genes Dev 1997, 11:2295-2322.
12. Lu W, Mayer BJ: Mechanism of activation of Pak1 kinase by membrane localization. Oncogene 1999, 18:797-806.
13. Scita G, Tenca P, Frittoli E, Tocchetti A, Innocenti M, Giardina G, Di Fiore PP: Signaling from Ras to Rac and beyond: not just a matter of GEFs. Embo J 2000, 19:2393-2398.
14. Radziwill G, Erdmann RA, Margelisch U, Moelling K: The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain. Mol Cell Biol 2003, 23:4663-4672.
15. Whitehead IP, Campbell S, Rossman KL, Der CJ: Dbl family proteins. Biochim Biophys Acta 1997, 1332:F1-23.
16. Alberts AS, Treisman R: Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1. Embo J 1998, 17:4075-4085.
17. Grignani F, Kinsella T, Mencarelli A, Valtieri M, Riganelli D, Grignani F, Lanfrancone L, Peschle C, Nolan GP, Pelicci PG: High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein. Cancer Res 1998, 58:14-19.
18. Maru Y, Witte ON, Shibuya M: BCR-ABL induces neurite-like structures and BCR lacking the SH2-binding domain induces cell rounding in PC12 cells. Exp Cell Res 1996, 229:438-445.
19. Bug G, Rossmanith T, Henschler R, Kunz-Schughart LA, Schroder B, Kampfmann M, Kreutz M, Hoelzer D, Ottmann OG: Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells. J Leukoc Biol 2002, 72:837-45. 2: Harder F et al. Human hematopoiesis in murine...[PMID: 11781263]Related Articles, Links.
20. van Buul JD, Hordijk PL: Signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol 2004, 24:824-833.
21. Pfeifer H, Wassmann B, Hofmann WK, Komor M, Scheuring U, Bruck P, Binckebanck A, Schleyer E, Gokbuget N, Wolff T, Lubbert M, Leimer L, Gschaidmeier H, Hoelzer D, Ottmann OG: Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate. Clin Cancer Res 2003, 9:4674-81. 2: Wassmann B et al. Early prediction of response ...[PMID: 14576058]Related Articles, Links.
22. Mohle R, Moore MA, Nachman RL, Rafii S: Transendothelial migration of CD34+ and mature hematopoietic cells: an in vitro study using a human bone marrow endothelial cell line. Blood 1997, 89:72-80.
23. Chuang TH, Xu X, Kaartinen V, Heisterkamp N, Groffen J, Bokoch GM: Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci U S A 1995, 92:10282-10286.
24. Harnois T, Constantin B, Rioux A, Grenioux E, Kitzis A, Bourmeyster N: Differential interaction and activation of Rho family GTPases by p210bcr-abl and p190bcr-abl. Oncogene 2003, 22:6445-6454.
25. Salesse S, Verfaillie CM: Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML. Oncogene 2002, 21:8605-8611.
26. Unwin RD, Sternberg DW, Lu Y, Pierce A, Gilliland DG, Whetton AD: Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ ABL. J Biol Chem 2005, 280:6316-6326.
27. Pelletier SD, Hong DS, Hu Y, Liu Y, Li S: Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice. Blood 2004, 104:2163-2171.