메뉴 건너뛰기




Volumn 6, Issue 12, 2006, Pages 2884-2893

P-glycoprotein functions as a differentiation switch in antigen presenting cell maturation

Author keywords

Antigen presenting cell; CD80; Dendritic cell; Interleukin 12; P glycoprotein; Th1

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CHLORDANE; GAMMA INTERFERON; GLYCOPROTEIN P; INTERLEUKIN 12; INTERLEUKIN 5; VALSPODAR;

EID: 33751160779     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2006.01561.x     Document Type: Article
Times cited : (33)

References (48)
  • 1
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 2
    • 0031045622 scopus 로고    scopus 로고
    • Origin, maturation and antigen presenting function of dendritic cells
    • Cella M, Sallusto F, Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 1997; 9: 10-16.
    • (1997) Curr Opin Immunol , vol.9 , pp. 10-16
    • Cella, M.1    Sallusto, F.2    Lanzavecchia, A.3
  • 3
    • 0034654532 scopus 로고    scopus 로고
    • A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells
    • Blanas E, Davey GM, Carbone FR et al. A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells. J Immunol 2000; 164: 2890-2896.
    • (2000) J Immunol , vol.164 , pp. 2890-2896
    • Blanas, E.1    Davey, G.M.2    Carbone, F.R.3
  • 4
    • 0035159272 scopus 로고    scopus 로고
    • Cutting edge: The related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activation
    • Gonzalo JA, Delaney T, Corcoran J et al. Cutting edge: the related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activation. J Immunol 2001; 166: 1-5.
    • (2001) J Immunol , vol.166 , pp. 1-5
    • Gonzalo, J.A.1    Delaney, T.2    Corcoran, J.3
  • 5
    • 0034571173 scopus 로고    scopus 로고
    • The molecular basis of T helper 1 and T helper 2 cell differentiation
    • O'Garra A, Arai N. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol 2000; 10: 542-550.
    • (2000) Trends Cell Biol , vol.10 , pp. 542-550
    • O'Garra, A.1    Arai, N.2
  • 6
    • 0029014952 scopus 로고
    • Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells
    • Macatonia SE, Hosken NA, Litton M et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 1995; 154: 5071-5079.
    • (1995) J Immunol , vol.154 , pp. 5071-5079
    • Macatonia, S.E.1    Hosken, N.A.2    Litton, M.3
  • 7
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3: 133-146.
    • (2003) Nat Rev Immunol , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 8
    • 0036138624 scopus 로고    scopus 로고
    • Enzyme-linked immunosorbent spot assay analysis of peripheral blood lymphocyte reactivity to donor HLA-DR peptides: Potential novel assay for prediction of outcomes for renal transplant recipients
    • Najafian N, Salama AD, Fedoseyeva EV et al. Enzyme-linked immunosorbent spot assay analysis of peripheral blood lymphocyte reactivity to donor HLA-DR peptides: potential novel assay for prediction of outcomes for renal transplant recipients. J Am Soc Nephrol 2002; 13: 252-259.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 252-259
    • Najafian, N.1    Salama, A.D.2    Fedoseyeva, E.V.3
  • 9
    • 0034008487 scopus 로고    scopus 로고
    • Dendritic cells: Immunological sentinels with a central role in health and disease
    • Stockwin LH, McGonagle D, Martin IG et al. Dendritic cells: immunological sentinels with a central role in health and disease. Immunol Cell Biol 2000; 78: 91-102.
    • (2000) Immunol Cell Biol , vol.78 , pp. 91-102
    • Stockwin, L.H.1    McGonagle, D.2    Martin, I.G.3
  • 10
  • 11
    • 0036431735 scopus 로고    scopus 로고
    • Induction of immune tolerance by dendritic cells: Implications for preventative and therapeutic immunotherapy of autoimmune disease
    • Thompson AG, Thomas R. Induction of immune tolerance by dendritic cells: implications for preventative and therapeutic immunotherapy of autoimmune disease. Immunol Cell Biol 2002; 80: 509-519.
    • (2002) Immunol Cell Biol , vol.80 , pp. 509-519
    • Thompson, A.G.1    Thomas, R.2
  • 12
    • 0027218689 scopus 로고
    • Biochemistry of multi-drug resistance mediated by the multi-drug transporter
    • Gottesman MM, Pastan I. Biochemistry of multi-drug resistance mediated by the multi-drug transporter. Annu Rev Biochem 1993; 62: 385-427.
    • (1993) Annu Rev Biochem , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 13
    • 0032900953 scopus 로고    scopus 로고
    • Biochemical, cellular and pharmacological aspects of the multi-drug transporter
    • Ambudkar SV, Dey S, Hrycyna CA et al. Biochemical, cellular and pharmacological aspects of the multi-drug transporter. Annu Rev Pharmacol Toxicol 1999; 39: 361-398.
    • (1999) Annu Rev Pharmacol Toxicol , vol.39 , pp. 361-398
    • Ambudkar, S.V.1    Dey, S.2    Hrycyna, C.A.3
  • 14
    • 0026465461 scopus 로고
    • Expression and activity of the multi-drug resistance P-glycoprotein in human peripheral blood lymphocytes
    • Chaudhary PM, Mechetner EB, Roninson IB. Expression and activity of the multi-drug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 1992; 80: 2735-2739.
    • (1992) Blood , vol.80 , pp. 2735-2739
    • Chaudhary, P.M.1    Mechetner, E.B.2    Roninson, I.B.3
  • 15
    • 0026489452 scopus 로고
    • Subpopulations of normal peripheral blood and bone marrow cells express a functional multi-drug resistant phenotype
    • Drach D, Zhao S, Drach J et al. Subpopulations of normal peripheral blood and bone marrow cells express a functional multi-drug resistant phenotype. Blood 1992; 80: 2729-2734.
    • (1992) Blood , vol.80 , pp. 2729-2734
    • Drach, D.1    Zhao, S.2    Drach, J.3
  • 16
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • Borst P, Elferink RO. Mammalian ABC transporters in health and disease. Annu Rev Biochem 2002; 71: 537-592.
    • (2002) Annu Rev Biochem , vol.71 , pp. 537-592
    • Borst, P.1    Elferink, R.O.2
  • 17
    • 0037931318 scopus 로고    scopus 로고
    • P-glycoprotein-a novel therapeutic target for immunomodulation in clinical transplantation and autoimmunity?
    • Pendse S, Sayegh MH, Frank MH. P-glycoprotein-a novel therapeutic target for immunomodulation in clinical transplantation and autoimmunity? Curr Drug Targets 2003; 4: 469-476.
    • (2003) Curr Drug Targets , vol.4 , pp. 469-476
    • Pendse, S.1    Sayegh, M.H.2    Frank, M.H.3
  • 18
    • 0028210704 scopus 로고
    • P-glycoprotein expression and function in circulating blood cells from normal volunteers
    • Klimecki WT, Futscher BW, Grogan TM et al. P-glycoprotein expression and function in circulating blood cells from normal volunteers. Blood 1994; 83: 2451-2458.
    • (1994) Blood , vol.83 , pp. 2451-2458
    • Klimecki, W.T.1    Futscher, B.W.2    Grogan, T.M.3
  • 19
    • 0027275829 scopus 로고
    • P-glycoprotein (MDR 1 gene product) in cells of the immune system: Its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection
    • Gupta S, Gollapudi S. P-glycoprotein (MDR 1 gene product) in cells of the immune system: its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection. J Clin Immunol 1993; 13: 289-301.
    • (1993) J Clin Immunol , vol.13 , pp. 289-301
    • Gupta, S.1    Gollapudi, S.2
  • 20
    • 0035865057 scopus 로고    scopus 로고
    • Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro
    • Frank MH, Denton MD, Alexander SI et al. Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro. J Immunol 2001; 166: 2451-2459.
    • (2001) J Immunol , vol.166 , pp. 2451-2459
    • Frank, M.H.1    Denton, M.D.2    Alexander, S.I.3
  • 21
    • 0037083639 scopus 로고    scopus 로고
    • Up-regulation of drug resistance-related vaults during dendritic cell development
    • Schroeijers AB, Reurs AW, Scheffer GL et al. Up-regulation of drug resistance-related vaults during dendritic cell development. J Immunol 2002; 168: 1572-1578.
    • (2002) J Immunol , vol.168 , pp. 1572-1578
    • Schroeijers, A.B.1    Reurs, A.W.2    Scheffer, G.L.3
  • 22
    • 0032499681 scopus 로고    scopus 로고
    • A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
    • Randolph GJ, Beaulieu S, Pope M et al. A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels. Proc Natl Acad Sci U S A 1998; 95: 6924-6929.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6924-6929
    • Randolph, G.J.1    Beaulieu, S.2    Pope, M.3
  • 23
    • 0034235459 scopus 로고    scopus 로고
    • IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells
    • Nagayama H, Sato K, Kawasaki H et al. IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells. J Immunol 2000; 165: 59-66.
    • (2000) J Immunol , vol.165 , pp. 59-66
    • Nagayama, H.1    Sato, K.2    Kawasaki, H.3
  • 24
    • 0030717709 scopus 로고    scopus 로고
    • Dendritic cells, interleukin 12 and CD4+ lymphocytes in the initiation of class I-restricted reactivity to a tumor/self peptide
    • Grohmann U, Fioretti MC, Bianchi R et al. Dendritic cells, interleukin 12 and CD4+ lymphocytes in the initiation of class I-restricted reactivity to a tumor/self peptide. Crit Rev Immunol 1998; 18: 87-98.
    • (1998) Crit Rev Immunol , vol.18 , pp. 87-98
    • Grohmann, U.1    Fioretti, M.C.2    Bianchi, R.3
  • 25
    • 0031775746 scopus 로고    scopus 로고
    • Dendritic cell survival and maturation are regulated by different signaling pathways
    • Rescigno M, Martino M, Sutherland CL et al. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998; 188: 2175-2180.
    • (1998) J Exp Med , vol.188 , pp. 2175-2180
    • Rescigno, M.1    Martino, M.2    Sutherland, C.L.3
  • 26
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down regulated by tumor necrosis factor alpha
    • Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down regulated by tumor necrosis factor alpha. J Exp Med 1994; 179: 1109-1118.
    • (1994) J Exp Med , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 27
    • 0032969112 scopus 로고    scopus 로고
    • Expression of surface antigens during the differentiation of human dendritic cells versus macrophages from blood monocytes in vitro
    • Santin AD, Hermonat PL, Ravaggi A et al. Expression of surface antigens during the differentiation of human dendritic cells versus macrophages from blood monocytes in vitro. Immunobiology 1999; 200: 187-204.
    • (1999) Immunobiology , vol.200 , pp. 187-204
    • Santin, A.D.1    Hermonat, P.L.2    Ravaggi, A.3
  • 28
    • 0344076299 scopus 로고    scopus 로고
    • Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application
    • Thurner B, Roder C, Dieckmann D et al. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J Immunol Methods 1999; 223: 1-15.
    • (1999) J Immunol Methods , vol.223 , pp. 1-15
    • Thurner, B.1    Roder, C.2    Dieckmann, D.3
  • 29
    • 0034767717 scopus 로고    scopus 로고
    • Standardized generation of fully mature p70 IL-12 secreting monocyte- derived dendritic cells for clinical use
    • Spisek R, Bretaudeau L, Barbieux I et al. Standardized generation of fully mature p70 IL-12 secreting monocyte- derived dendritic cells for clinical use. Cancer Immunol Immunother 2001; 50: 417-427.
    • (2001) Cancer Immunol Immunother , vol.50 , pp. 417-427
    • Spisek, R.1    Bretaudeau, L.2    Barbieux, I.3
  • 30
    • 0034192259 scopus 로고    scopus 로고
    • Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells
    • Komi J, Lassila O. Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells. Blood 2000; 95: 2875-2882.
    • (2000) Blood , vol.95 , pp. 2875-2882
    • Komi, J.1    Lassila, O.2
  • 31
    • 0030613634 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833
    • van Asperen J, van Tellingen O, Sparreboom A et al. Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. Br J Cancer 1997; 76: 1181-1183.
    • (1997) Br J Cancer , vol.76 , pp. 1181-1183
    • Van Asperen, J.1    Van Tellingen, O.2    Sparreboom, A.3
  • 32
    • 0032619473 scopus 로고    scopus 로고
    • Treatment of poor prognosis AML patients using PSC833 (valspodar) plus mitoxantrone, etoposide and cytarabine (PSC-MEC)
    • Advani R, Visani G, Milligan D et al. Treatment of poor prognosis AML patients using PSC833 (valspodar) plus mitoxantrone, etoposide and cytarabine (PSC-MEC). Adv Exp Med Biol 1999; 457: 47-56.
    • (1999) Adv Exp Med Biol , vol.457 , pp. 47-56
    • Advani, R.1    Visani, G.2    Milligan, D.3
  • 33
    • 0026701132 scopus 로고
    • Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells
    • D'Andrea A, Rengaraju M, Valiante NM et al. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 1992; 176: 1387-1398.
    • (1992) J Exp Med , vol.176 , pp. 1387-1398
    • D'Andrea, A.1    Rengaraju, M.2    Valiante, N.M.3
  • 34
    • 0344012471 scopus 로고    scopus 로고
    • Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter
    • Frank NY, Pendse SS, Lapchak PH et al. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem 2003; 278: 47156-47165.
    • (2003) J Biol Chem , vol.278 , pp. 47156-47165
    • Frank, N.Y.1    Pendse, S.S.2    Lapchak, P.H.3
  • 35
    • 20144364789 scopus 로고    scopus 로고
    • ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma
    • Frank NY, Margaryan A, Huang Y et al. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res 2005; 65: 4320-4333.
    • (2005) Cancer Res , vol.65 , pp. 4320-4333
    • Frank, N.Y.1    Margaryan, A.2    Huang, Y.3
  • 36
    • 0027474061 scopus 로고
    • Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins
    • Mar 15
    • Holness CL, Simmons DL. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood Mar 15 1993; 81: 1607-1613.
    • (1993) Blood , vol.81 , pp. 1607-1613
    • Holness, C.L.1    Simmons, D.L.2
  • 37
    • 0027272822 scopus 로고
    • A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily
    • Sep
    • Law SK, Micklem KJ, Shaw JM et al. A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur J Immunol Sep 1993; 23: 2320-2325.
    • (1993) Eur J Immunol , vol.23 , pp. 2320-2325
    • Law, S.K.1    Micklem, K.J.2    Shaw, J.M.3
  • 38
    • 17644385178 scopus 로고    scopus 로고
    • A basis for distinguishing cultured dendritic cells and macrophages in cytospins and fixed sections
    • Vakkila J, Lotze MT, Riga C et al. A basis for distinguishing cultured dendritic cells and macrophages in cytospins and fixed sections. Pediatr Dev Pathol 2005; 8: 43-51.
    • (2005) Pediatr Dev Pathol , vol.8 , pp. 43-51
    • Vakkila, J.1    Lotze, M.T.2    Riga, C.3
  • 39
    • 0032167420 scopus 로고    scopus 로고
    • A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment
    • de Saint-Vis B, Vincent J, Vandenabeele S et al. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity 1998; 9: 325-336.
    • (1998) Immunity , vol.9 , pp. 325-336
    • De Saint-Vis, B.1    Vincent, J.2    Vandenabeele, S.3
  • 40
    • 0032168336 scopus 로고    scopus 로고
    • IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production
    • Grohmann U, Belladonna ML, Bianchi R et al. IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production. Immunity 1998; 9: 315-323.
    • (1998) Immunity , vol.9 , pp. 315-323
    • Grohmann, U.1    Belladonna, M.L.2    Bianchi, R.3
  • 41
    • 0029073090 scopus 로고
    • Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?
    • Thompson CB. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell 1995; 81: 979-982.
    • (1995) Cell , vol.81 , pp. 979-982
    • Thompson, C.B.1
  • 42
    • 0028949152 scopus 로고
    • B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
    • Kuchroo VK, Das MP, Brown JA et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995; 80: 707-718.
    • (1995) Cell , vol.80 , pp. 707-718
    • Kuchroo, V.K.1    Das, M.P.2    Brown, J.A.3
  • 43
    • 0031881038 scopus 로고    scopus 로고
    • Recent advances in understanding the molecular mechanisms of tamoxifen action
    • Friedman ZY. Recent advances in understanding the molecular mechanisms of tamoxifen action. Cancer Invest 1998; 16: 391-396.
    • (1998) Cancer Invest , vol.16 , pp. 391-396
    • Friedman, Z.Y.1
  • 44
    • 0035469855 scopus 로고    scopus 로고
    • The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells
    • Ohishi K, Varnum-Finney B, Serda RE et al. The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells. Blood 2001; 98: 1402-1407.
    • (2001) Blood , vol.98 , pp. 1402-1407
    • Ohishi, K.1    Varnum-Finney, B.2    Serda, R.E.3
  • 45
    • 2342496710 scopus 로고    scopus 로고
    • Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
    • Amsen D, Blander JM, Lee GR et al. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 2004; 117: 515-526.
    • (2004) Cell , vol.117 , pp. 515-526
    • Amsen, D.1    Blander, J.M.2    Lee, G.R.3
  • 46
    • 33751163818 scopus 로고    scopus 로고
    • MDRI specific pharmacologic P-glycoprotein blockade prolongs murine cardiac allograft survival
    • Izawa A, Frank NY, Pendse S, Sayegh MH, Frank MH. MDRI specific pharmacologic P-glycoprotein blockade prolongs murine cardiac allograft survival. Am J Transplant 2003; 3 (5 Suppl): 447..
    • (2003) Am J Transplant , vol.3 , Issue.5 SUPPL. , pp. 447
    • Izawa, A.1    Frank, N.Y.2    Pendse, S.3    Sayegh, M.H.4    Frank, M.H.5
  • 47
    • 0025843705 scopus 로고
    • Multi-drug resistance in heart transplant patients: A preliminary communication on a possible mechanism of therapy-resistant rejection
    • Kemnitz J, Uysal A, Haverich A et al. Multi-drug resistance in heart transplant patients: a preliminary communication on a possible mechanism of therapy-resistant rejection. J Heart Lung Transplant 1991; 10: 201-210.
    • (1991) J Heart Lung Transplant , vol.10 , pp. 201-210
    • Kemnitz, J.1    Uysal, A.2    Haverich, A.3
  • 48
    • 0027480161 scopus 로고
    • Multi-drug resistance in lung allograft recipients: Possible correlation with the development of acute and chronic rejection
    • Yousem SA, Sartori D, Sonmez-Alpan E. Multi-drug resistance in lung allograft recipients: possible correlation with the development of acute and chronic rejection. J Heart Lung Transplant 1993; 12: 20-26.
    • (1993) J Heart Lung Transplant , vol.12 , pp. 20-26
    • Yousem, S.A.1    Sartori, D.2    Sonmez-Alpan, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.