Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro

Journal of Immunology

Volumn 166, Issue 4, 2001, Pages 2451-2459

  Frank, M H ^a   Denton, M D ^a   Alexander, S I ^a   Khoury, S J ^a   Sayegh, M H ^a   Briscoe, D M ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; GAMMA INTERFERON; GLYCOPROTEIN P; INTERLEUKIN 12; INTERLEUKIN 2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY HYB 241; TAMOXIFEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLOIMMUNITY; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DOSE RESPONSE; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; MULTIDRUG RESISTANCE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN TARGETING; T LYMPHOCYTE ACTIVATION;

EID: 0035865057     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.4.2451     Document Type: Article

References (49)

1. Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport
2. Biochemistry of multidrug resistance mediated by the multidrug transporter
3. Expression of a multidrug-resistance gene in human tumors and tissues
4. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
5. P-glycoprotein functions and substrates: Possible roles of MDR1 gene in the kidney
6. Multidrug-resistance phenotype of a subpopulation of T-lymphocytes without drug selection
7. Multidrug resistance activity in human lymphocytes
8. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
9. Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype
10. Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes
11. Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells
12. + T cells: A role in cytotoxic effector function
13. P-glycoprotein expression and function in circulating blood cells from normal volunteers
14. Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production
15. Expression of MDR1 by normal bone marrow cells and its implication for leukemic hematopoiesis
16. Heterogeneity in P-glycoprotein (multidrug resistance) activity among murine peripheral T cells: Correlation with surface phenotype and effector function
17. Mdr1a-encoded P-glycoprotein is not required for peripheral T cell proliferation, cytokine release, or cytotoxic effector function in mice
18. Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-γ in normal human T lymphocytes
19. Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes
20. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking
21. A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels
22. Multidrug resistance in heart transplant patients: A preliminary communication on a possible mechanism of therapy-resistant rejection
23. Multidrug resistance in lung allograft recipients: Possible correlation with the development of acute and chronic rejection
24. Identification of an inducible endothelial-leukocyte adhesion molecule
25. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy
26. Features of apoptotic cells measured by flow cytometry
27. Differentiation and assessment of cell death
28. Monoclonal antibodies specific for P-glycoprotein
29. Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay
30. P-glycoprotein (MDR 1 gene product) in cells of the immune system: Its possible physiologic role and alteration in aging and human immunodeficiency virus-1 (HIV-1) infection
31. PSC833, cyclosporin A, and dexniguldipine effects on cellular calcein retention and inhibition of the multidrug resistance pump in human leukemic lymphoblasts
32. Recent advances in understanding the molecular mechanisms of tamoxifen action
33. High-dose oral tamoxifen, a potential multidrug-resistance-reversal agent: Phase I trial in combination with vinblastine
34. Reversal of Vinca alkaloid resistance by anti-P-glycoprotein monoclonal antibody HYB-241 in a human tumor xenograft
35. Activation of human peripheral blood T cells does not lead to increased P-glycoprotein expression
36. Mechanisms of allo-recognition: Recognition by in vivo-primed T cells of specific major histocompatibility complex polymorphisms presented as peptides by responder antigen-presenting cells
37. + T cells
38. Genes regulating MHC class I processing of antigen
39. Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein
40. Volume-regulated chloride channels associated with the human multidrug- resistance P-glycoprotein
41. ATP-activated chloride channel inhibited by an antibody to P glycoprotein
42. P-glycoprotein-associated chloride currents revealed by specific block by an anti-P-glycoprotein antibody
43. - current and volume regulation in bovine ciliary epithelial cells
44. Molecular identification of a volume-regulated chloride channel
45. The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease
46. Small-conductance chloride channels in human peripheral T lymphocytes
47. Chloride-channel block inhibits T lymphocyte activation and signalling
48. - currents inhibit endothelial cell proliferation