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Volumn 20, Issue 4, 2006, Pages 179-188

The impact of donor age and recipient age on clinical course and immune response after organ transplantation

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL PROTOCOL; GERIATRIC PATIENT; GRAFT RECIPIENT; HOSPITAL ADMISSION; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; ORGAN DONOR; ORGAN TRANSPLANTATION; OUTCOME ASSESSMENT; REVIEW;

EID: 33751091728     PISSN: 0955470X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trre.2006.07.005     Document Type: Review
Times cited : (2)

References (98)
  • 1
    • 18644377233 scopus 로고    scopus 로고
    • Impact of the expanded criteria donor allocation system on the use of expanded criteria donor kidneys
    • Sung R.S., Guidinger M.K., Lake C.D., McBride M.A., Greenstein S.M., Delmonico F.L., et al. Impact of the expanded criteria donor allocation system on the use of expanded criteria donor kidneys. Transplantation 79 9 (2005) 1257-1261
    • (2005) Transplantation , vol.79 , Issue.9 , pp. 1257-1261
    • Sung, R.S.1    Guidinger, M.K.2    Lake, C.D.3    McBride, M.A.4    Greenstein, S.M.5    Delmonico, F.L.6
  • 2
    • 0035126261 scopus 로고    scopus 로고
    • Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates
    • Ojo A.O., Hanson J.A., Meier-Kriesche H., Okechukwu C.N., Wolfe R.A., Leichtman A.B., et al. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J Am Soc Nephrol 12 3 (2001) 589-597
    • (2001) J Am Soc Nephrol , vol.12 , Issue.3 , pp. 589-597
    • Ojo, A.O.1    Hanson, J.A.2    Meier-Kriesche, H.3    Okechukwu, C.N.4    Wolfe, R.A.5    Leichtman, A.B.6
  • 3
    • 2342526548 scopus 로고    scopus 로고
    • Similar risk profiles for post-transplant renal dysfunction and long-term graft failure: UNOS/OPTN database analysis
    • Siddiqi N., McBride M.A., and Hariharan S. Similar risk profiles for post-transplant renal dysfunction and long-term graft failure: UNOS/OPTN database analysis. Kidney Int 65 5 (2004) 1906-1913
    • (2004) Kidney Int , vol.65 , Issue.5 , pp. 1906-1913
    • Siddiqi, N.1    McBride, M.A.2    Hariharan, S.3
  • 4
    • 0033609024 scopus 로고    scopus 로고
    • Renal transplantation in recipients over the age of 60: the impact of donor age
    • Basar H., Soran A., Shapiro R., Vivas C., Scantlebury V.P., Jordan M.L., et al. Renal transplantation in recipients over the age of 60: the impact of donor age. Transplantation 67 8 (1999) 1191-1193
    • (1999) Transplantation , vol.67 , Issue.8 , pp. 1191-1193
    • Basar, H.1    Soran, A.2    Shapiro, R.3    Vivas, C.4    Scantlebury, V.P.5    Jordan, M.L.6
  • 7
    • 7444263945 scopus 로고    scopus 로고
    • Modifications of immune regulations with increasing donor & recipient age
    • Pascher A., Pratschke J., Neuhaus P., and Tullius S.G. Modifications of immune regulations with increasing donor & recipient age. Ann Transplant 9 1 (2004) 72-73
    • (2004) Ann Transplant , vol.9 , Issue.1 , pp. 72-73
    • Pascher, A.1    Pratschke, J.2    Neuhaus, P.3    Tullius, S.G.4
  • 8
    • 33751093390 scopus 로고    scopus 로고
    • OPTN/SRTR annual report 2005. http://www.optn.org/data/annual.Report.asp.
  • 9
    • 28844501802 scopus 로고    scopus 로고
    • Deceased-donor characteristics and the survival benefit of kidney transplantation
    • Merion R.M., Ashby V.B., Wolfe R.A., Distant D.A., Hulbert-Shearon T.E., Metzger R.A., et al. Deceased-donor characteristics and the survival benefit of kidney transplantation. JAMA 294 21 (2005) 2726-2733
    • (2005) JAMA , vol.294 , Issue.21 , pp. 2726-2733
    • Merion, R.M.1    Ashby, V.B.2    Wolfe, R.A.3    Distant, D.A.4    Hulbert-Shearon, T.E.5    Metzger, R.A.6
  • 10
    • 30944464626 scopus 로고    scopus 로고
    • The impact of waiting time and comorbid conditions on the survival benefit of kidney transplantation
    • Gill J.S., Tonelli M., Johnson N., Kiberd B., Landsberg D., and Pereira B.J. The impact of waiting time and comorbid conditions on the survival benefit of kidney transplantation. Kidney Int 68 5 (2005) 2345-2351
    • (2005) Kidney Int , vol.68 , Issue.5 , pp. 2345-2351
    • Gill, J.S.1    Tonelli, M.2    Johnson, N.3    Kiberd, B.4    Landsberg, D.5    Pereira, B.J.6
  • 11
    • 10044274372 scopus 로고    scopus 로고
    • How old is old for transplantation?
    • Oniscu G.C., Brown H., and Forsythe J.L. How old is old for transplantation?. Am J Transplant 4 12 (2004) 2067-2074
    • (2004) Am J Transplant , vol.4 , Issue.12 , pp. 2067-2074
    • Oniscu, G.C.1    Brown, H.2    Forsythe, J.L.3
  • 13
    • 0036054038 scopus 로고    scopus 로고
    • Acute rejection in the elderly recipient: influence of age in the outcome of kidney transplantation
    • Palomar R., Ruiz J.C., Zubimendi J.A., Cotorruelo J.G., de Francisco A.L., Rodrigo E., et al. Acute rejection in the elderly recipient: influence of age in the outcome of kidney transplantation. Int Urol Nephrol 33 1 (2002) 145-148
    • (2002) Int Urol Nephrol , vol.33 , Issue.1 , pp. 145-148
    • Palomar, R.1    Ruiz, J.C.2    Zubimendi, J.A.3    Cotorruelo, J.G.4    de Francisco, A.L.5    Rodrigo, E.6
  • 14
    • 0035679073 scopus 로고    scopus 로고
    • Interaction between acute rejection and recipient age on long-term renal allograft survival
    • Meier-Kriesche H.U., Srinivas T.R., and Kaplan B. Interaction between acute rejection and recipient age on long-term renal allograft survival. Transplant Proc 33 7-8 (2001) 3425-3426
    • (2001) Transplant Proc , vol.33 , Issue.7-8 , pp. 3425-3426
    • Meier-Kriesche, H.U.1    Srinivas, T.R.2    Kaplan, B.3
  • 15
    • 25444503011 scopus 로고    scopus 로고
    • Long-term patient and graft survival in the eurotransplant senior program: a single-center experience
    • Fabrizii V., Kovarik J., Bodingbauer M., Kramar R., Horl W.H., and Winkelmayer W.C. Long-term patient and graft survival in the eurotransplant senior program: a single-center experience. Transplantation 80 5 (2005) 582-589
    • (2005) Transplantation , vol.80 , Issue.5 , pp. 582-589
    • Fabrizii, V.1    Kovarik, J.2    Bodingbauer, M.3    Kramar, R.4    Horl, W.H.5    Winkelmayer, W.C.6
  • 16
    • 33645363571 scopus 로고    scopus 로고
    • Living kidney donors >60 years of age: is it acceptable for the donor and the recipient?
    • Neipp M., Jackobs S., Jaeger M., Schwarz A., Lueck R., Gwinner W., et al. Living kidney donors >60 years of age: is it acceptable for the donor and the recipient?. Transpl Int 19 3 (2006) 213-217
    • (2006) Transpl Int , vol.19 , Issue.3 , pp. 213-217
    • Neipp, M.1    Jackobs, S.2    Jaeger, M.3    Schwarz, A.4    Lueck, R.5    Gwinner, W.6
  • 17
    • 25144455593 scopus 로고    scopus 로고
    • Older living donors provide excellent quality kidneys: a single center experience (older living donors)
    • Johnson S.R., Khwaja K., Pavlakis M., Monaco A.P., and Hanto D.W. Older living donors provide excellent quality kidneys: a single center experience (older living donors). Clin Transplant 19' 5 (2005) 600-606
    • (2005) Clin Transplant , vol.19 , Issue.5 , pp. 600-606
    • Johnson, S.R.1    Khwaja, K.2    Pavlakis, M.3    Monaco, A.P.4    Hanto, D.W.5
  • 18
    • 4644266302 scopus 로고    scopus 로고
    • Factors associated with primary and secondary graft failure following cadaveric kidney transplant
    • Weiss-Salz I., Mandel M., Galai N., Nave I., Boner G., Mor E., et al. Factors associated with primary and secondary graft failure following cadaveric kidney transplant. Clin Transplant 18 5 (2004) 571-575
    • (2004) Clin Transplant , vol.18 , Issue.5 , pp. 571-575
    • Weiss-Salz, I.1    Mandel, M.2    Galai, N.3    Nave, I.4    Boner, G.5    Mor, E.6
  • 19
    • 11144353972 scopus 로고    scopus 로고
    • Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant
    • Stratta R.J., Rohr M.S., Sundberg A.K., Armstrong G., Hairston G., Hartmann E., et al. Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant. Ann Surg 239 5 (2004) 688-695
    • (2004) Ann Surg , vol.239 , Issue.5 , pp. 688-695
    • Stratta, R.J.1    Rohr, M.S.2    Sundberg, A.K.3    Armstrong, G.4    Hairston, G.5    Hartmann, E.6
  • 20
    • 33746206556 scopus 로고    scopus 로고
    • Intermediate-term outcomes with expanded criteria deceased donors in kidney transplantation: a spectrum or specter of quality?
    • Stratta R.J., Rohr M.S., Sundberg A.K., Farney A.C., Hartmann E.L., Moore P.S., et al. Intermediate-term outcomes with expanded criteria deceased donors in kidney transplantation: a spectrum or specter of quality?. Ann Surg 243 5 (2006) 594-603
    • (2006) Ann Surg , vol.243 , Issue.5 , pp. 594-603
    • Stratta, R.J.1    Rohr, M.S.2    Sundberg, A.K.3    Farney, A.C.4    Hartmann, E.L.5    Moore, P.S.6
  • 21
    • 0034653643 scopus 로고    scopus 로고
    • Increased immunosuppressive vulnerability in elderly renal transplant recipients
    • Meier-Kriesche H.U., Ojo A., Hanson J., Cibrik D., Lake K., Agodoa L.Y., et al. Increased immunosuppressive vulnerability in elderly renal transplant recipients. Transplantation 69 5 (2000) 885-889
    • (2000) Transplantation , vol.69 , Issue.5 , pp. 885-889
    • Meier-Kriesche, H.U.1    Ojo, A.2    Hanson, J.3    Cibrik, D.4    Lake, K.5    Agodoa, L.Y.6
  • 22
    • 0033610699 scopus 로고    scopus 로고
    • Infectious complications in geriatric renal transplant patients: comparison of two immunosuppressive protocols
    • Meier-Kriesche H.U., Friedman G., Jacobs M., Mulgaonkar S., Vaghela M., and Kaplan B. Infectious complications in geriatric renal transplant patients: comparison of two immunosuppressive protocols. Transplantation 68 10 (1999) 1496-1502
    • (1999) Transplantation , vol.68 , Issue.10 , pp. 1496-1502
    • Meier-Kriesche, H.U.1    Friedman, G.2    Jacobs, M.3    Mulgaonkar, S.4    Vaghela, M.5    Kaplan, B.6
  • 23
    • 0037090852 scopus 로고    scopus 로고
    • Is mycophenolate mofetil less safe than azathioprine in elderly renal transplant recipients?
    • Johnson D.W., Nicol D.L., Purdie D.M., Preston J.M., Brown A.M., Hawley C.M., et al. Is mycophenolate mofetil less safe than azathioprine in elderly renal transplant recipients?. Transplantation 73 7 (2002) 1158-1163
    • (2002) Transplantation , vol.73 , Issue.7 , pp. 1158-1163
    • Johnson, D.W.1    Nicol, D.L.2    Purdie, D.M.3    Preston, J.M.4    Brown, A.M.5    Hawley, C.M.6
  • 25
    • 21044443129 scopus 로고    scopus 로고
    • A calcineurin antagonist-free induction/maintenance strategy for immunosuppression in elderly recipients of renal allografts from elderly cadaver donors: long-term results from a prospective single centre trial
    • Arbogast H., Huckelheim H., Schneeberger H., Illner W.D., Tarabichi A., Fertmann J., et al. A calcineurin antagonist-free induction/maintenance strategy for immunosuppression in elderly recipients of renal allografts from elderly cadaver donors: long-term results from a prospective single centre trial. Clin Transplant 19 3 (2005) 309-315
    • (2005) Clin Transplant , vol.19 , Issue.3 , pp. 309-315
    • Arbogast, H.1    Huckelheim, H.2    Schneeberger, H.3    Illner, W.D.4    Tarabichi, A.5    Fertmann, J.6
  • 27
    • 27644528849 scopus 로고    scopus 로고
    • Preferential allocation of marginal kidney allografts to elderly recipients combined with modified immunosuppression gives good results
    • Segoloni G.P., Messina M., Squiccimarro G., Mazzucco G., Torta E., Leonardi G., et al. Preferential allocation of marginal kidney allografts to elderly recipients combined with modified immunosuppression gives good results. Transplantation 80 7 (2005) 953-958
    • (2005) Transplantation , vol.80 , Issue.7 , pp. 953-958
    • Segoloni, G.P.1    Messina, M.2    Squiccimarro, G.3    Mazzucco, G.4    Torta, E.5    Leonardi, G.6
  • 28
    • 0028063518 scopus 로고
    • Cyclosporine monotherapy versus OKT3 and cyclosporine versus prednisone and cyclosporine as induction therapy in older renal transplant patients: a multicenter randomized study. Spanish Monotherapy Study Group
    • Spanish Monotherapy Study Group
    • Spanish Monotherapy Study Group. Cyclosporine monotherapy versus OKT3 and cyclosporine versus prednisone and cyclosporine as induction therapy in older renal transplant patients: a multicenter randomized study. Spanish Monotherapy Study Group. Transplant Proc 26 5 (1994) 2522-2524
    • (1994) Transplant Proc , vol.26 , Issue.5 , pp. 2522-2524
  • 29
    • 0028072241 scopus 로고
    • Renal transplantation for patients 60 years or older. A single-institution experience
    • Benedetti E., Matas A.J., Hakim N., Fasola C., Gillingham K., McHugh L., et al. Renal transplantation for patients 60 years or older. A single-institution experience. Ann Surg 220 4 (1994) 445-458
    • (1994) Ann Surg , vol.220 , Issue.4 , pp. 445-458
    • Benedetti, E.1    Matas, A.J.2    Hakim, N.3    Fasola, C.4    Gillingham, K.5    McHugh, L.6
  • 30
    • 6844236357 scopus 로고    scopus 로고
    • Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. Daclizumab Triple Therapy Study Group
    • Vincenti F., Kirkman R., Light S., Bumgardner G., Pescovitz M., Halloran P., et al. Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. Daclizumab Triple Therapy Study Group. N Engl J Med 338 3 (1998) 161-165
    • (1998) N Engl J Med , vol.338 , Issue.3 , pp. 161-165
    • Vincenti, F.1    Kirkman, R.2    Light, S.3    Bumgardner, G.4    Pescovitz, M.5    Halloran, P.6
  • 31
    • 0026903840 scopus 로고
    • In renal transplantation, one size may not fit all
    • Brenner B.M., Cohen R.A., and Milford E.L. In renal transplantation, one size may not fit all. J Am Soc Nephrol 3 2 (1992) 162-169
    • (1992) J Am Soc Nephrol , vol.3 , Issue.2 , pp. 162-169
    • Brenner, B.M.1    Cohen, R.A.2    Milford, E.L.3
  • 32
    • 0032946290 scopus 로고    scopus 로고
    • Rethinking chronic allograft nephropathy: the concept of accelerated senescence
    • Halloran P.F., Melk A., and Barth C. Rethinking chronic allograft nephropathy: the concept of accelerated senescence. J Am Soc Nephrol 10 1 (1999) 167-181
    • (1999) J Am Soc Nephrol , vol.10 , Issue.1 , pp. 167-181
    • Halloran, P.F.1    Melk, A.2    Barth, C.3
  • 33
    • 20544432681 scopus 로고    scopus 로고
    • Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney
    • Melk A., Schmidt B.M., Vongwiwatana A., Rayner D.C., and Halloran P.F. Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney. Am J Transplant 5 6 (2005) 1375-1382
    • (2005) Am J Transplant , vol.5 , Issue.6 , pp. 1375-1382
    • Melk, A.1    Schmidt, B.M.2    Vongwiwatana, A.3    Rayner, D.C.4    Halloran, P.F.5
  • 34
    • 1642561702 scopus 로고    scopus 로고
    • Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney
    • Melk A., Schmidt B.M., Takeuchi O., Sawitzki B., Rayner D.C., and Halloran P.F. Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney. Kidney Int 65 2 (2004) 510-520
    • (2004) Kidney Int , vol.65 , Issue.2 , pp. 510-520
    • Melk, A.1    Schmidt, B.M.2    Takeuchi, O.3    Sawitzki, B.4    Rayner, D.C.5    Halloran, P.F.6
  • 36
    • 0030321746 scopus 로고    scopus 로고
    • A multi-factor analysis of kidney graft outcomes at one and five years posttransplantation: 1996 UNOS update
    • Gjertson D.W. A multi-factor analysis of kidney graft outcomes at one and five years posttransplantation: 1996 UNOS update. Clin Transpl (1996) 343-360
    • (1996) Clin Transpl , pp. 343-360
    • Gjertson, D.W.1
  • 38
    • 0036140604 scopus 로고    scopus 로고
    • Interaction between donor and recipient age in determining the risk of chronic renal allograft failure
    • Meier-Kriesche H.U., Cibrik D.M., Ojo A.O., Hanson J.A., Magee J.C., Rudich S.M., et al. Interaction between donor and recipient age in determining the risk of chronic renal allograft failure. J Am Geriatr Soc 50 1 (2002) 14-17
    • (2002) J Am Geriatr Soc , vol.50 , Issue.1 , pp. 14-17
    • Meier-Kriesche, H.U.1    Cibrik, D.M.2    Ojo, A.O.3    Hanson, J.A.4    Magee, J.C.5    Rudich, S.M.6
  • 40
    • 0025176643 scopus 로고
    • Increased major histocompatibility complex antigen expression in unilateral ischemic acute tubular necrosis in the mouse
    • Shoskes D.A., Parfrey N.A., and Halloran P.F. Increased major histocompatibility complex antigen expression in unilateral ischemic acute tubular necrosis in the mouse. Transplantation 49 1 (1990) 201-207
    • (1990) Transplantation , vol.49 , Issue.1 , pp. 201-207
    • Shoskes, D.A.1    Parfrey, N.A.2    Halloran, P.F.3
  • 41
    • 0031965469 scopus 로고    scopus 로고
    • A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism
    • Khoruts A., Mondino A., Pape K.A., Reiner S.L., and Jenkins M.K. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J Exp Med 187 2 (1998) 225-236
    • (1998) J Exp Med , vol.187 , Issue.2 , pp. 225-236
    • Khoruts, A.1    Mondino, A.2    Pape, K.A.3    Reiner, S.L.4    Jenkins, M.K.5
  • 45
    • 0028828999 scopus 로고
    • Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma
    • Goes N.., Sims T., Urmson J., Vincent D., Ramassar V., and Halloran P.F. Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma. J Immunol 155 (1995) 4559-4566
    • (1995) J Immunol , vol.155 , pp. 4559-4566
    • Goes, N..1    Sims, T.2    Urmson, J.3    Vincent, D.4    Ramassar, V.5    Halloran, P.F.6
  • 46
    • 0033951305 scopus 로고    scopus 로고
    • Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells
    • Lung T.L., Saurwein-Teissl M., Parson W., Schönitzer D., and Grubeck-Loebenstein B. Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cells. Vaccine 18 16 (2000) 1606-1612
    • (2000) Vaccine , vol.18 , Issue.16 , pp. 1606-1612
    • Lung, T.L.1    Saurwein-Teissl, M.2    Parson, W.3    Schönitzer, D.4    Grubeck-Loebenstein, B.5
  • 47
    • 0036246614 scopus 로고    scopus 로고
    • Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease
    • Ordemann R., Hutchinson R., Friedman J., Burakoff S.J., Reddy P., Duffner U., et al. Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease. J Clin Invest 109 9 (2002) 1249-1256
    • (2002) J Clin Invest , vol.109 , Issue.9 , pp. 1249-1256
    • Ordemann, R.1    Hutchinson, R.2    Friedman, J.3    Burakoff, S.J.4    Reddy, P.5    Duffner, U.6
  • 48
    • 0033106240 scopus 로고    scopus 로고
    • Antigen presenting cell function is enhanced in healthy elderly
    • Castle S.C., Uyemura K., Crawford W., Wong W., and Makinodan T. Antigen presenting cell function is enhanced in healthy elderly. Mech Ageing Dev 107 2 (1999) 137-145
    • (1999) Mech Ageing Dev , vol.107 , Issue.2 , pp. 137-145
    • Castle, S.C.1    Uyemura, K.2    Crawford, W.3    Wong, W.4    Makinodan, T.5
  • 49
    • 0030987990 scopus 로고    scopus 로고
    • The "injury response": a concept linking nonspecific injury, acute rejection, and long-term transplant outcomes
    • Halloran P.F., Homik J., Goes N., Lui S.L., Urmson J., Ramassar V., et al. The "injury response": a concept linking nonspecific injury, acute rejection, and long-term transplant outcomes. Transplant Proc 29 1-2 (1997) 79-81
    • (1997) Transplant Proc , vol.29 , Issue.1-2 , pp. 79-81
    • Halloran, P.F.1    Homik, J.2    Goes, N.3    Lui, S.L.4    Urmson, J.5    Ramassar, V.6
  • 50
    • 20144389665 scopus 로고    scopus 로고
    • Grafts from elderly donors elicit a stronger immune response in the early period posttransplantation: a study in a rat model
    • Reutzel-Selke A., Filatenkov A., Jurisch A., Denecke C., Martins P.N.A., Pascher A., et al. Grafts from elderly donors elicit a stronger immune response in the early period posttransplantation: a study in a rat model. Transplant Proc 37 (2005) 382-383
    • (2005) Transplant Proc , vol.37 , pp. 382-383
    • Reutzel-Selke, A.1    Filatenkov, A.2    Jurisch, A.3    Denecke, C.4    Martins, P.N.A.5    Pascher, A.6
  • 52
    • 0033951533 scopus 로고    scopus 로고
    • NK and NK/T cells in human senescence
    • Solana R., and Mariani E. NK and NK/T cells in human senescence. Vaccine 18 16 (2000) 1613-1620
    • (2000) Vaccine , vol.18 , Issue.16 , pp. 1613-1620
    • Solana, R.1    Mariani, E.2
  • 53
    • 20344399856 scopus 로고    scopus 로고
    • Impaired apoptosis and immune senescence-cause or effect?
    • Hsu H.C., Scott D.K., and Mountz J.D. Impaired apoptosis and immune senescence-cause or effect?. Immunol Rev 205 (2005) 130-146
    • (2005) Immunol Rev , vol.205 , pp. 130-146
    • Hsu, H.C.1    Scott, D.K.2    Mountz, J.D.3
  • 54
    • 1642568184 scopus 로고    scopus 로고
    • Significant presence of terminally differentiated T cells and altered NF-kappaB and I-kappaBalpha interactions in healthy ageing
    • Ivory K., Martin R., and Hughes D.A. Significant presence of terminally differentiated T cells and altered NF-kappaB and I-kappaBalpha interactions in healthy ageing. Exp Gerontol 39 4 (2004) 567-576
    • (2004) Exp Gerontol , vol.39 , Issue.4 , pp. 567-576
    • Ivory, K.1    Martin, R.2    Hughes, D.A.3
  • 55
    • 0037198061 scopus 로고    scopus 로고
    • Cell signaling in aging and apoptosis
    • Suh Y. Cell signaling in aging and apoptosis. Mech Ageing Dev 123 8 (2002) 881-890
    • (2002) Mech Ageing Dev , vol.123 , Issue.8 , pp. 881-890
    • Suh, Y.1
  • 56
    • 0032519426 scopus 로고    scopus 로고
    • Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax
    • Aggarwal S., and Gupta S. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. Immunol 160 4 (1998) 1627-1637
    • (1998) Immunol , vol.160 , Issue.4 , pp. 1627-1637
    • Aggarwal, S.1    Gupta, S.2
  • 57
    • 1642421839 scopus 로고    scopus 로고
    • Decreased proliferative capability of CD4(+) cells of elderly people is associated with faster loss of activation-related antigens and accumulation of regulatory T cells
    • Bryl E., and Witkowski J.M. Decreased proliferative capability of CD4(+) cells of elderly people is associated with faster loss of activation-related antigens and accumulation of regulatory T cells. Exp Gerontol 39 4 (2004) 587-595
    • (2004) Exp Gerontol , vol.39 , Issue.4 , pp. 587-595
    • Bryl, E.1    Witkowski, J.M.2
  • 60
    • 24044463890 scopus 로고    scopus 로고
    • Dysregulation of T-cell function in the elderly: scientific basis and clinical implications
    • Fulop T., Larbi A., Wikby A., Mocchegiani E., Hirokawa K., and Pawelec G. Dysregulation of T-cell function in the elderly: scientific basis and clinical implications. Drugs Aging 22 7 (2005) 589-603
    • (2005) Drugs Aging , vol.22 , Issue.7 , pp. 589-603
    • Fulop, T.1    Larbi, A.2    Wikby, A.3    Mocchegiani, E.4    Hirokawa, K.5    Pawelec, G.6
  • 61
    • 0029826636 scopus 로고    scopus 로고
    • Antigen-independent changes in naive CD4 T cells with aging
    • Linton P.J., Haynes L., Klinman N.R., and Swain S.L. Antigen-independent changes in naive CD4 T cells with aging. J Exp Med 184 5 (1996) 1891-1900
    • (1996) J Exp Med , vol.184 , Issue.5 , pp. 1891-1900
    • Linton, P.J.1    Haynes, L.2    Klinman, N.R.3    Swain, S.L.4
  • 62
    • 0344304396 scopus 로고    scopus 로고
    • CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly
    • Haynes L., Eaton S.M., Burns E.M., Randall T.D., and Swain S.L. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci U S A 100 25 (2003) 15053-15058
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.25 , pp. 15053-15058
    • Haynes, L.1    Eaton, S.M.2    Burns, E.M.3    Randall, T.D.4    Swain, S.L.5
  • 63
    • 0034194058 scopus 로고    scopus 로고
    • Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging
    • Fagnoni F.F., Vescovini R., Passeri G., Bologna G., Pedrazzoni M., Lavagetto G., et al. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. Blood 95 9 (2000) 2860-2868
    • (2000) Blood , vol.95 , Issue.9 , pp. 2860-2868
    • Fagnoni, F.F.1    Vescovini, R.2    Passeri, G.3    Bologna, G.4    Pedrazzoni, M.5    Lavagetto, G.6
  • 64
    • 0037097656 scopus 로고    scopus 로고
    • Early antigen-specific response by naive CD8 T cells is not altered with aging
    • Li S.P., Cai Z., Shi W., Brunmark A., Jackson M., and Linton P.J. Early antigen-specific response by naive CD8 T cells is not altered with aging. J Immunol 168 12 (2002) 6120-6127
    • (2002) J Immunol , vol.168 , Issue.12 , pp. 6120-6127
    • Li, S.P.1    Cai, Z.2    Shi, W.3    Brunmark, A.4    Jackson, M.5    Linton, P.J.6
  • 66
    • 20344374699 scopus 로고    scopus 로고
    • Intrinsic versus environmental influences on T-cell responses in aging
    • Linton P.J., Li S.P., Zhang Y., Bautista B., Huynh Q., and Trinh T. Intrinsic versus environmental influences on T-cell responses in aging. Immunol Rev 205 (2005) 207-219
    • (2005) Immunol Rev , vol.205 , pp. 207-219
    • Linton, P.J.1    Li, S.P.2    Zhang, Y.3    Bautista, B.4    Huynh, Q.5    Trinh, T.6
  • 67
    • 0033061933 scopus 로고    scopus 로고
    • + T cells as determined by four-color flow cytometry analysis
    • + T cells as determined by four-color flow cytometry analysis. J Gerontol A Biol Sci Med Sci 54 3 (1999) B116-B123
    • (1999) J Gerontol A Biol Sci Med Sci , vol.54 , Issue.3
    • Mu, X.Y.1    Thoman, M.L.2
  • 68
    • 9244265523 scopus 로고    scopus 로고
    • Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense
    • Messaoudi I., Lemaoult J., Guevara-Patino J.A., Metzner B.M., and Nikolich-Zugich J. Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J Exp Med 200 10 (2004) 1347-1358
    • (2004) J Exp Med , vol.200 , Issue.10 , pp. 1347-1358
    • Messaoudi, I.1    Lemaoult, J.2    Guevara-Patino, J.A.3    Metzner, B.M.4    Nikolich-Zugich, J.5
  • 69
    • 0035915757 scopus 로고    scopus 로고
    • Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish Longitudinal OCTO Immune Study
    • Olsson J., Wikby A., Johansson B., Lofgren S., Nilsson B.O., and Ferguson F.G. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish Longitudinal OCTO Immune Study. Mech Ageing Dev 121 1-3 (2000) 187-201
    • (2000) Mech Ageing Dev , vol.121 , Issue.1-3 , pp. 187-201
    • Olsson, J.1    Wikby, A.2    Johansson, B.3    Lofgren, S.4    Nilsson, B.O.5    Ferguson, F.G.6
  • 73
    • 0037442121 scopus 로고    scopus 로고
    • - T cells in aged mice are hyporesponsive and exhibit suppressive activity
    • - T cells in aged mice are hyporesponsive and exhibit suppressive activity. J Immunol 170 4 (2003) 1675-1682
    • (2003) J Immunol , vol.170 , Issue.4 , pp. 1675-1682
    • Shimizu, J.1    Moriizumi, E.2
  • 75
    • 0031309026 scopus 로고    scopus 로고
    • Transplantation in the elderly: a review
    • Jassal S.V., Opelz G., and Cole E. Transplantation in the elderly: a review. Geriatr Nephrol Urol 7 3 (1997) 157-165
    • (1997) Geriatr Nephrol Urol , vol.7 , Issue.3 , pp. 157-165
    • Jassal, S.V.1    Opelz, G.2    Cole, E.3
  • 76
    • 0034654334 scopus 로고    scopus 로고
    • Renal transplantation in older adults: is graft survival affected by age? A case control study
    • Lufft V., Kliem V., Tusch G., Dannenberg B., and Brunkhorst R. Renal transplantation in older adults: is graft survival affected by age? A case control study. Transplantation 69 5 (2000) 790-794
    • (2000) Transplantation , vol.69 , Issue.5 , pp. 790-794
    • Lufft, V.1    Kliem, V.2    Tusch, G.3    Dannenberg, B.4    Brunkhorst, R.5
  • 77
    • 0142090729 scopus 로고    scopus 로고
    • Old-for-old kidney allocation allows successful expansion of the donor and recipient pool
    • Fritsche L., Horstrup J., Budde K., Reinke P., Giessing M., Tullius S., et al. Old-for-old kidney allocation allows successful expansion of the donor and recipient pool. Am J Transplant 3 11 (2003) 1434-1439
    • (2003) Am J Transplant , vol.3 , Issue.11 , pp. 1434-1439
    • Fritsche, L.1    Horstrup, J.2    Budde, K.3    Reinke, P.4    Giessing, M.5    Tullius, S.6
  • 78
    • 0035678963 scopus 로고    scopus 로고
    • Influence of recipient and donor age on long-term renal allograft function in an experimental model
    • Tullius S.G., Reutzel-Selke A., Bachmann U., Jurisch A., Nieminen-Kelha M., Pratschke J., et al. Influence of recipient and donor age on long-term renal allograft function in an experimental model. Transplant Proc 33 7-8 (2001) 3345-3346
    • (2001) Transplant Proc , vol.33 , Issue.7-8 , pp. 3345-3346
    • Tullius, S.G.1    Reutzel-Selke, A.2    Bachmann, U.3    Jurisch, A.4    Nieminen-Kelha, M.5    Pratschke, J.6
  • 79
    • 10744232130 scopus 로고    scopus 로고
    • Alterations of the immune response with increasing recipient age are associated with reduced long-term organ graft function of rat kidney allografts
    • Pascher A., Reutzel-Selke A., Jurisch A., Bachmann U., Heidenhain C., Nickel P., et al. Alterations of the immune response with increasing recipient age are associated with reduced long-term organ graft function of rat kidney allografts. Transplantation 76 11 (2003) 1560-1568
    • (2003) Transplantation , vol.76 , Issue.11 , pp. 1560-1568
    • Pascher, A.1    Reutzel-Selke, A.2    Jurisch, A.3    Bachmann, U.4    Heidenhain, C.5    Nickel, P.6
  • 80
    • 0030454155 scopus 로고    scopus 로고
    • Inhibition of transplant coronary arteriosclerosis in rabbits by chronic estradiol treatment is associated with abolition of MHC class II antigen expression
    • Lou H., Kodama T., Zhao Y.J., Maurice P., Wang Y.N., Katz N., et al. Inhibition of transplant coronary arteriosclerosis in rabbits by chronic estradiol treatment is associated with abolition of MHC class II antigen expression. Circulation 94 12 (1996) 3355-3361
    • (1996) Circulation , vol.94 , Issue.12 , pp. 3355-3361
    • Lou, H.1    Kodama, T.2    Zhao, Y.J.3    Maurice, P.4    Wang, Y.N.5    Katz, N.6
  • 81
    • 0033566737 scopus 로고    scopus 로고
    • Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes
    • Heeger P.S., Greenspan N.S., Kuhlenschmidt S., Dejelo C., Hricik D.E., Schulak J.A., et al. Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes. J Immunol 163 4 (1999) 2267-2275
    • (1999) J Immunol , vol.163 , Issue.4 , pp. 2267-2275
    • Heeger, P.S.1    Greenspan, N.S.2    Kuhlenschmidt, S.3    Dejelo, C.4    Hricik, D.E.5    Schulak, J.A.6
  • 83
    • 0345476290 scopus 로고    scopus 로고
    • Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
    • Wells A.D., Li X.C., Li Y., Walsh M.C., Zheng X.X., Wu Z., et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 5 11 (1999) 1303-1307
    • (1999) Nat Med , vol.5 , Issue.11 , pp. 1303-1307
    • Wells, A.D.1    Li, X.C.2    Li, Y.3    Walsh, M.C.4    Zheng, X.X.5    Wu, Z.6
  • 85
    • 10744228165 scopus 로고    scopus 로고
    • Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance
    • Zheng X.X., Sanchez-Fueyo A., Sho M., Domenig C., Sayegh M.H., and Strom T.B. Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity 19 4 (2003) 503-514
    • (2003) Immunity , vol.19 , Issue.4 , pp. 503-514
    • Zheng, X.X.1    Sanchez-Fueyo, A.2    Sho, M.3    Domenig, C.4    Sayegh, M.H.5    Strom, T.B.6
  • 87
    • 0028349005 scopus 로고
    • An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease
    • Burrows S.R., Khanna R., Burrows J.M., and Moss D.J. An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease. J Exp Med 179 4 (1994) 1155-1161
    • (1994) J Exp Med , vol.179 , Issue.4 , pp. 1155-1161
    • Burrows, S.R.1    Khanna, R.2    Burrows, J.M.3    Moss, D.J.4
  • 89
    • 0033961897 scopus 로고    scopus 로고
    • Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody
    • Welsh R.M., Markees T.G., Woda B.A., Daniels K.A., Brehm M.A., Mordes J.P., et al. Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. J Virol 74 (2000) 2210-2218
    • (2000) J Virol , vol.74 , pp. 2210-2218
    • Welsh, R.M.1    Markees, T.G.2    Woda, B.A.3    Daniels, K.A.4    Brehm, M.A.5    Mordes, J.P.6
  • 90
    • 0042320414 scopus 로고    scopus 로고
    • Memory T cells: a hurdle to immunologic tolerance
    • Lakkis F.G., and Sayegh M.H. Memory T cells: a hurdle to immunologic tolerance. J Am Soc Nephrol 14 9 (2003) 2402-2410
    • (2003) J Am Soc Nephrol , vol.14 , Issue.9 , pp. 2402-2410
    • Lakkis, F.G.1    Sayegh, M.H.2
  • 91
    • 18644381515 scopus 로고    scopus 로고
    • Testicular immune privilege promotes transplantation tolerance by altering the balance between memory and regulatory T cells
    • Nasr I.W., Wang Y., Gao G., Deng S., Diggs L., Rothstein D.M., et al. Testicular immune privilege promotes transplantation tolerance by altering the balance between memory and regulatory T cells. J Immunol 174 10 (2005) 6161-6168
    • (2005) J Immunol , vol.174 , Issue.10 , pp. 6161-6168
    • Nasr, I.W.1    Wang, Y.2    Gao, G.3    Deng, S.4    Diggs, L.5    Rothstein, D.M.6
  • 92
    • 0036664218 scopus 로고    scopus 로고
    • Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice
    • Valujskikh A., Pantenburg B., and Heeger P.S. Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice. Am J Transplant 2 6 (2002) 501-509
    • (2002) Am J Transplant , vol.2 , Issue.6 , pp. 501-509
    • Valujskikh, A.1    Pantenburg, B.2    Heeger, P.S.3
  • 93
  • 94
    • 0033557297 scopus 로고    scopus 로고
    • Role of the thymus in transplantation tolerance in miniature swine: II. Effect of steroids and age on the induction of tolerance to class I mismatched renal allografts
    • Yamada K., Gianello P.R., Ierino F.L., Fishbein J., Lorf T., Shimizu A., et al. Role of the thymus in transplantation tolerance in miniature swine: II. Effect of steroids and age on the induction of tolerance to class I mismatched renal allografts. Transplantation 67 3 (1999) 458-467
    • (1999) Transplantation , vol.67 , Issue.3 , pp. 458-467
    • Yamada, K.1    Gianello, P.R.2    Ierino, F.L.3    Fishbein, J.4    Lorf, T.5    Shimizu, A.6
  • 95
    • 1942451817 scopus 로고    scopus 로고
    • Role of the thymus in transplantation tolerance in miniature swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance
    • Vagefi P.A., Ierino F.L., Gianello P.R., Shimizu A., Kamano C., Sachs D.H., et al. Role of the thymus in transplantation tolerance in miniature swine: IV. The thymus is required during the induction phase, but not the maintenance phase, of renal allograft tolerance. Transplantation 77 7 (2004) 979-985
    • (2004) Transplantation , vol.77 , Issue.7 , pp. 979-985
    • Vagefi, P.A.1    Ierino, F.L.2    Gianello, P.R.3    Shimizu, A.4    Kamano, C.5    Sachs, D.H.6
  • 96
    • 1642350860 scopus 로고    scopus 로고
    • Vascularized thymic lobe transplantation in miniature swine: thymopoiesis and tolerance induction across fully MHC-mismatched barriers
    • Kamano C., Vagefi P.A., Kumagai N., Yamamoto S., Barth R.N., LaMattina J.C., et al. Vascularized thymic lobe transplantation in miniature swine: thymopoiesis and tolerance induction across fully MHC-mismatched barriers. Proc Natl Acad Sci U S A 101 11 (2004) 3827-3832
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.11 , pp. 3827-3832
    • Kamano, C.1    Vagefi, P.A.2    Kumagai, N.3    Yamamoto, S.4    Barth, R.N.5    LaMattina, J.C.6
  • 97
    • 33751084928 scopus 로고    scopus 로고
    • Tullius SG, Lehmann M, Filatenkov A, Schmidt H, Reutzel-Selke A, Schröder G, et al. The allograft by itself induces regulatory T cells-immunosuppression needs to spare this mechanism to induce tolerance [submitted for publication].
  • 98
    • 33751090507 scopus 로고    scopus 로고
    • Rat-cytomegalovirus infection interferes with anti-CD4-mAb (RIB 5/2)-induced tolerance and induces chronic allograft dysfunction
    • Pascher A., Prösch S., Filatenkow A., Reutzel-Selke A., Lehmann M., Pratschke J., et al. Rat-cytomegalovirus infection interferes with anti-CD4-mAb (RIB 5/2)-induced tolerance and induces chronic allograft dysfunction. Am J Transplant 5 Suppl 11 (2005) 365
    • (2005) Am J Transplant , vol.5 , Issue.SUPPL. 11 , pp. 365
    • Pascher, A.1    Prösch, S.2    Filatenkow, A.3    Reutzel-Selke, A.4    Lehmann, M.5    Pratschke, J.6


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