Adenosine does not bind to the growth hormone secretagogue receptor type-1a (GHS-R1a)

Journal of Endocrinology

Volumn 191, Issue 1, 2006, Pages 147-157

  Carreira, Marcos C ^b   Camiña, Jesus P ^b   Díaz Rodríguez, Esther ^b   Alvear Perez, Rodrigo ^a   Llorens Cortes, Catherine ^a   Casanueva, Felipe F ^b  

^a INSERM   (France)

^b HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE B2 RECEPTOR; ADENOSINE B3 RECEPTOR; ADENOSINE RECEPTOR; CALCIUM; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; GROWTH HORMONE SECRETAGOGUE RECEPTOR 1A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM CELL LEVEL; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOCYTOSIS; GENE OVEREXPRESSION; HORMONE BINDING; HORMONE RELEASE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADENOSINE; ANIMALS; ARVICOLINAE; BLOTTING, WESTERN; CALCIUM; CELL LINE; CHO CELLS; CRICETINAE; HUMANS; KIDNEY; MICROSCOPY, CONFOCAL; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A2B; RECEPTOR, ADENOSINE A3; RECEPTORS, G-PROTEIN-COUPLED; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 33751055314     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.06714     Document Type: Article

References (31)

1. Bondensgard K, Ankersen M, Thogersen H, Hansen BS, Wuff BS & Bywater RP 2004 Recognition of privileged structures by G-protein coupled receptors. Journal of Medical Chemistry 47 888-899.
2. Camina JP, Carreira MC, El Messari S, Llorens-Cortes C, Smith RG & Casanueva FF 2004 Desensitization and endocytosis mechanisms of ghlrelin-activated growth hormone secretagogue receptor 1a, Endocrinology 145 930-940.
3. Carreira MC, Camina JP, Smith RG & Casanueva FF 2004 Agonist-specific coupling of growth hormone secretagogue receptor type 1 a to different intracellular signaling systems. Role of adenosine. Neuroendocrinology 79 13-25.
4. Cooper J, Hill SJ & Alexander SP 1997 An endogenous A2B adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells. British Journal of Pharmacology 122 546-550.
5. Deghenghi R, Papotti M, Ghigo E & Muccioh G 2001 Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. Journal of Endocrinological Investigation 24 RC1-RC3.
6. Devi LA 2001 Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trends in Pharmacological Sciences 22 532-537.
7. Feighner SD, Howard AD, Prendergast K, Palyha OC, Hreniuk DL, Nargund R, Underwood D, Tata JR, Dean DC, Tan CP et al. 1998 Structural requirements for the activation of the human growth hormone secretagogue receptor by pepticle and nonpeptide secretagogues. Molecular Endocrinology 12 137-145.
8. Feokdstov I & Biaggioni I 1997 Adenosine A2B receptors. Pharmacological Reviews 49 381-402.
9. Ferre S, Torvinen M, Antoniou K, Irenius E, Civelli O, Arenas E, Fredholm BB & Fuxe K 1998 Adenosine A1 receptor-mediated modulation of dopamine D1 receptors in stably cotransfected fibroblast cells. Journal of Biological Chemistry 273 4718-4724.
10. Gao Z, Chen T, Weber MJ & Linden J 1999 A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. Cross-talk between cyclic AMP and protein kinase c pathways. Journal of Biological Chemistry 274 5972-5980.
11. George SR, Fan T, Xie Z, Tse R, Tam V, Varghese G & O'Dowd BF 2000 Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. Journal of Biological Chemistry 275 26128-26135.
12. Halem HA, Taylor JE, Dong JZ, Shen Y, Datta R, Abizaid A, Diano S, Horvath T, Zizzari P Bluet-Pajot MT et al. 2004 Novel analogs of ghrelin: physiological and clinical implications. European Journal of Endocrinology 151 S71-S75.
13. Holst B, Cygankievicz A, Jensen TH, Ankersen M & Schwartz TW 2003 High constitutive signaling of the receptor-identification of a potent inverse agonist. Molecular Endocrinology 17 2201-2210.
14. Holst B, Holliday ND, Bach A, Elling CE, Cox HM & Schwartz TW 2004 Common structural basis for constitutive activity of the receptor family. Journal of Biological Chemistry 279 53806-53817.
15. Johansson S, Fredholm BB, Hjort C, Morein T, Kull B & Hu. PS 2005 Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor. Biochemical Pharmacology 70 598-605.
16. Jordan BA & Devi LA 1999 G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399 697-700.
17. Korbonits M, Goldstone AP, Gueorguiev M & Grossman AB 2004 Ghrelin, a hormone with multiple functions. Frontiers in Neuroendocrinology 25 27-68.
18. Lall S, Balthasar N, Carmignac D, Magoulas C, Sesay A, Houston P, Mathers K & Robinson I 2004 Physiological studies of transgenic mice overexpressing growth hormone (GH) secretagogue receptor 1A in GH-releasing hormone neurons. Endocrinology 145 1602-1611.
19. Linden J, Thai T, Figler H, Jin X & Robeva AS 1999 Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells. Molecular Pharmacology 56 705-713.
20. Maudsley S, Martin B & Luttrell LM 2005 The origins of diversity and specificity in G-protein-coupled receptor signaling. Journal of Pharmacology and Experimental Therapeutics 314 485-494.
21. Mittal RA, Tan CH & Khoo HE 1999 Evidence for A1 and A2B adenosine receptors in baby hamster kidney (BHK) cells. Biofactors 10 25-33.
22. Peters DM, Gies EK, Gelb CR & Peterfreund RA 1998 Agonist-induced desensitization of A2b adenosine receptors. Biochemical Pharmacology 55 873-882.
23. Ralevic V & Burnstock G 1998 Receptors for purines and pyrimidines. Pharmacological Reviews 50 413-492.
24. Rios CD, Jordan BA, Gomes I & Devi LA 2001 G-protein-coupled receptor dimerization: modulation ofreceptor function. Pharmacology & Therapeutics 92 71-87.
25. Shuto Y, Shibasaki T, Otagiri A, Kuriyama H, Ohata H, Tamura H, Kamegai J, Sugihara H, Oikawa S & Wakabayashi I 2002 Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. Journal of Clinical Investigation 109 1429-1436.
26. Smith RG, Griffin PR, Xu Y, Smith AG, Liu K, Calacay J, Feighner SD, Pong C, Leong D, Pomes A et al. 2000 Adenosine: a partial agonist of the growth hormone secretagogue receptor. Biochemical and Biophysical Research Communications 276 1306-1313.
27. Sun Y, Wang P, Zheng H & Smith RG 2004 Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. PNAS 101 4679-4684.
28. Terrillon S & Bouvier M 2004 Roles of G-protein-coupled receptors climerization. EMBO Reports 5 30-34.
29. Tullin S, Hansen BS, Ankersen M, Moller J, Von Cappelen KA & Thim L 2000 Adenosine is an agonist of the growth hormone secretagogue receptor. Endocrinology 141 3397-3402.
30. van der Lely A, Tschop M, Heiman ML & Ghigo E 2004 Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocrine Reviews 25 426-457.
31. Wettschureck N, Moers A, Willenwein B, Parlow AF, Maser-Gluth C & Offermanns S 2005 Loss of Gq/11 family G proteins in the nervous system causes pituitary somatotroph hypoplasia and dwarfism in mice. Molecular and Cellular Biology 25 1942-1948.