Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids

Fundamental and Clinical Pharmacology

Volumn 20, Issue 6, 2006, Pages 525-538

  Leaf, Alexander ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cardiac arrhythmias; Fish oil; Fish oil fatty acids; Prevention of cardiac deaths; Sudden cardiac death

Indexed keywords

DILTIAZEM; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; OLIVE OIL; OMEGA 3 FATTY ACID; PLACEBO;

CALCIUM CELL LEVEL; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; DEFIBRILLATOR; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; HEART ARRHYTHMIA; HEART DISEASE; HEART ELECTROPHYSIOLOGY; HEART INFARCTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HIGH RISK PATIENT; HUMAN; ISCHEMIC HEART DISEASE; NONHUMAN; PREVENTIVE MEDICINE; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SUDDEN DEATH; SUPRAVENTRICULAR TACHYCARDIA; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CLINICAL TRIALS; DEATH, SUDDEN, CARDIAC; DOGS; ELECTROCARDIOGRAPHY; FATTY ACIDS, OMEGA-3; FATTY ACIDS, UNSATURATED; FISH OILS; HUMANS; MODELS, BIOLOGICAL;

EID: 33751043565     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2006.00438.x     Document Type: Review

References (34)

1. Kromhout D. Fish consumption, n-3 fatty acids and coronary heart disease, in: Marmot M., Elliott P. (Eds), Coronary heart disease epidemiology: from aetiology to public health, Oxford University, Oxford, UK, 2005, pp. 264-274.
2. Albert C.M., Hennekens C.H., O'Donnell C.J. et al. Fish consumption and risk of sudden death. JAMA (1998) 279 23-28.
3. Siscovick D.S., Raghunathan T.E., King I. et al. Dietary intake and cell membrane levels of long chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. JAMA (1995) 274 1363-1367.
4. Albert C.M., Campos H., Stampfer M.J. et al. Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N. Engl. J. Med. (2002) 346 1113-1118.
5. Burr M., Fehily A.M., Gilbert J.F. et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet (1989) 334 757-761.
6. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet (1999) 354 447-455.
7. Leaf A., Albert C.A., Josephson M. et al. Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake. Circulation (2005) 112 2762-2768.
8. Tremoli E., Maderna P., Marangoni F. et al. Prolonged inhibition of platelet aggregation after n-3 fatty acid ethyl ester ingestion by healthy volunteers. Am. J. Clin. Nutr. (1995) 61 607-613.
9. Kalblusch J.D., Prentice R.L. The statistical analysis of failure time data, Wiley, New York, 1980.
10. McLennan P.L., Abeywardena M.Y., Charnock J.S. Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion. Am. Heart J. (1988) 116 709-717.
11. McLennan P.L. Relative effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on cardiac arrhythmias in rats. Am. J. Clin. Nutr. (1993) 57 207-212.
12. McLennan P.L., Bridle T.M., Abeywardena M.Y., Charnock J.S. Dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey. Am. Heart J. (1992) 123 1555-1561.
13. Billman G.E., Hallaq H., Leaf A. Prevention of ischemia-induced arrhythmias by n-3 fatty acids. Proc. Natl. Acad. Sci. U.S.A. (1994) 91 4427-4430.
14. Billman G.E., Kang J.X., Leaf A. Prevention of ischemia-induced cardiac sudden death by n-3 polyunsaturated fatty acids. Lipids (1997) 32 1161-1168.
15. Billman G.E., Kang J.X., Leaf A. Prevention of ischemia-induced cardiac sudden death by pure n-3 polyunsaturated fatty acids. Circulation (1999) 99 2452-2457.
16. Kang J.X., Leaf A. Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. Proc. Natl. Acad. Sci. U.S.A. (1994) 9 9886-9890.
17. Kang J.X., Leaf A. Prevention and termination of arrhythmias induced by lysophosphatidylcholine and acylcarnitine in neonatal rat cardiomyocytes by free n-3 polyunsaturated fatty acids. Eur. J. Pharmacol. (1996) 297 97-106.
18. Kang J.X., Leaf A. Prevention and termination of β-adrenergic agonist-induced arrhythmias by free polyunsaturated fatty acids in neonatal rat cardiac myocytes. Biochem. Biophys. Res. Commun. (1995) 208 629-636.
19. Li Y., Kang J.X., Leaf A. Differential effects of various eicosanoids on the production or prevention on arrhythmias in neonatal rat cardiac myocytes. Prostaglandins (1997) 54 511-530.
20. + channels of neonatal rat ventricular myocytes. Proc. Natl. Acad. Sci. U.S.A. (1995) 92 11000-11004.
21. + channels. Am. J. Physiol. (2000) 279 H35-H46.
22. Leaf A., Xiao Y-F., Kang J.X., Billman G.E. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. Pharmacol. Ther. (2003) 98 355-377.
23. Kang J.X., Xiao Y-F., Leaf A. Free long-chain polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. Proc. Natl. Acad. Sci. U.S.A. (1995) 92 3997-4001.
24. Leaf A., Kang J.X., Xiao Y-F., Billman G.E. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation (2003) 107 2646-2652.
25. 2+ currents by polyunsaturated fatty acids in adult and neonatal rat cardiac myocytes. Proc. Natl. Acad. Sci. U.S.A. (1997) 94 4182-4187.
26. Hille B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. (1977) 69 497-515.
27. Leaf A., Weber P.C. A new era for science in nutrition. Am. J. Clin. Nutr. (1987) 45 1048-1053.
28. Kang J.X., Li Y., Leaf A. Regulation of sodium channel gene expression by class 1 antiarrhythmic drugs and n-3 polyunsaturated fatty acids in cultured neonatal rat cardiac myocytes. Proc. Natl. Acad. Sci. U.S.A. (1997) 94 2724-2728.
29. Force T., Milani R., Hibberd P. et al. Aspirin-induced decline in prostacyclin production in patients with coronary heart disease is due to endoperoxide shift. Circulation (1991) 84 2286-2293.
30. + in adult ferret cardiomyocytes. Sheng Li Hsueh Pao (2002) 54 271-281.
31. Burr M.L., Ashfield-Watt P.A., Dunstan F.D. et al. Lack of benefit of dietary advice to men with angina: controlled trial. Eur. J. Clin. Nutr. (2003) 57 193-200.
32. Boden W.E., Krone R.J., Kleiger R.E. et al. Electrocardiographic subset analysis of diltiazem administration on the long-term outcome after acute myocardial infarction. Am. J. Cardiol. (1991) 67 335-342.
33. Raitt M.H., Connor W.E., Morris C. et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators. JAMA (2005) 293 2884-2891.
34. Brouwer I.A., Zock P.L., Camm A.J. et al. Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trial. JAMA (2006) 295 2613-2619.