Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes

European Journal of Pharmacology

Volumn 297, Issue 1-2, 1996, Pages 97-106

  Kang, Jing X ^a   Leaf, Alexander ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acylcarnitine; Antiarrhythmic; Excitability; Fatty acid; Fibrillation; Lysophosphatidylcholine

Indexed keywords

ARACHIDONIC ACID; BOVINE SERUM ALBUMIN; CALCIMYCIN; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM IONOPHORE; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; ICOSATETRAYNOIC ACID; LINOLEIC ACID; LINOLENIC ACID; LYSOPHOSPHATIDYLCHOLINE; OLEIC ACID; PALMITOYLCARNITINE; POLYUNSATURATED FATTY ACID; SODIUM CHANNEL BLOCKING AGENT; STEARIC ACID; TETRODOTOXIN; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROSTIMULATION; EXCITABILITY; HEART ARRHYTHMIA; HEART FIBRILLATION; HEART MUSCLE CELL; MUSCLE CONTRACTILITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RAT; TACHYCARDIA;

EID: 0030029410     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00701-6     Document Type: Article

References (44)

1. Arnsdorf, M.F. and G.J. Sawicki, 1981, The effects of lysophosphatidylcholine, a toxic metabolite of ischemia, on the components of cardiac excitability in sheep purkinje fibers, Circ. Res. 49, 16.
2. + concentrations, J. Mol. Cell. Cardiol. 16, 155.
3. Bergmann, S.R., Jr. Ferguson and B.E. Sobel, 1981, Effects of amphiphiles on erythrocytes, coronary arteries, and perfused hearts, Am. J. Physiol. 240 (Heart Circ. Physiol. 9), H229.
4. Billman, G.E., H. Hallaq and A. Leaf, 1994, Prevention of ischemia-induced ventricular fibrillation by omega-3 fatty acids, Proc. Natl. Acad. Sci. USA. 91, 4427.
5. Burnashev, N.A., A.I. Undrovinas, I.A. Fleidervish, J.C. Makielski and L.V. Rosenshtraukh, 1991, Modulation of cardiac sodium channel gating by lysophosphatidylcholine, J. Mol. Cell. Cardiol. 23 (Suppl. I), 23.
6. Burr, M.L., A.M. Fehily, J.F. Gilbert, S. Rogers, R.M. Holliday, P.M. Sweetnam, P.C. Elwood and N.M. Deadman, 1989, Effects of changes in fat, fish and fiber intakes on death and myocardial reinfartion: diet and reinfartion trial (DART), Lancet 334, 757.
7. Clarkson, C.W. and R.E. Ten Eick, 1983, On the mechanism of lysophosphatidylcholine-induced depolarization of cat ventricular myocardium, Circ. Res. 52, 543.
8. Corr, P.B., 1990, Contribution of lipid metabolites to arrhythmogenesis during early myocardial ischemia, in: Cardiac Electrophysiology: A Textbook, eds, M.R. Rosen, M.J. Janse and A. L. Wit (Futura Publishing Company, Inc., Mount Kisco, NY) p. 719.
9. Corr, P.B., M.E. Cain, F.X. Witkowski, D.A. Price and B.E. Sobel, 1979, Potential arrhythmogenic electrophysiological derangements in canine purkinje fibers induced by lysophosphoglycerides, Circ. Res. 44, 822.
10. Corr, P.B., D.W. Snyder, M.E. Cain, W.A. Crafford, R.W. Gross and B.E. Sobel, 1981, Electrophyysiological effects of amphiphiles on canine purkinje fibers: implications for dysrhythmia secondary to ischemia, Circ. Res. 49, 354.
11. Corr, P.B., D.W. Snyder, B.I. Lee, R.W. Gross, C.R. Keim and B.E. Sobel, 1982, Pathophysiological concentrations of lysophosphatides and the slow response, Am. J. Physiol. 243, H187.
12. Corr, P.B., R.W. Gross and B.E. Sobel, 1984, Amphipathic metabolites and membrane dysfunction in ischemic myocardium, Circ. Res. 55, 135.
13. Corr, P.B., J.E. Saffitz and B.E. Sobel, 1987a, Lysophospholipids, long chain acylcarnitines and membrane dysfunction in the ischaemic heart, Basic Res. Cardiol. 82 (Suppl.), 199.
14. Corr, P.B., K.A. Yamada, M.H. Creer, A.D. Sharma and B.E. Sobel, 1987b, Lysophosphoglycerides and ventricular fibrillation early after onset of ischemia, Mol. Cell. Cardiol. 19 (Suppl. V), 45.
15. Curtis, M.J., M.K. Pugsley and M.J.K. Walker, 1993, Endogenous chemical mediators of ventricular arrhythmias in ischemic heart disease, Cardiovasc. Res. 27, 703.
16. DaTorre, S.D., M.H. Creer, S.M. Pogwizd and P.B. Corr, 1991, Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart, J. Mol. Cell. Cardiol. 23 (Suppl. I), 11.
17. De Logeril, M., S. Renaud, N. Mamelle, P. Salen, J.-L. Martin, I. Monjaud, J. Guidollet P. Touboul and J. Delaye, 1994, Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease, Lancet. 343, 1454.
18. Duan, J. and M.P. Moffat, 1991, Protective effects of D,L-carnitine against arrhythmias induced by lysophosphatidylcholine or reperfusion, Eur. J. Pharmacol. 192, 355.
19. 2+ indicators with greatly improved fluorescence properties, J. Biol. Chem. 260, 3440.
20. Kang, J.X. and A. Leaf, 1994, Effects of long-chain, polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes, Proc. Natl. Acad. Sci. USA 91, 9886.
21. Kang, J.X. and A. Leaf, 1995, Prevention and termination of betaadrenergic agonist-induced arrhythmias by free polyunsaturated fatty acids in neonatal rat cardiac myocytes, Biochem. Biophys. Res. Commun. 208, 629.
22. Kang, J.X., Y.F. Xiao and A. Leaf, 1995, Free long-chain polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes, Proc. Natl. Acad. Sci. USA 92, 3997.
23. + stimulated ATPase activity of rabbit and dog heart sarcolemma by lysophosphatidylcholine, Life. Sci. 24, 1869.
24. Katz, A.M. and P.C. Messineo, 1981, Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium, Circ. Res. 48, 1.
25. Kinnaird, A.A.A., P.C. Choy and R.Y.K. Man, 1988, Lysophosphatidycholine accumulation in the ischemic canine heart, Lipids 23, 32.
26. Langer, G.A., A. J. Brady, S.T. Tan and S.E. Serena, 1975, Correlation of the glycoside response, the force staircase, and the action potential configuration in the neonatal rat heart, Circ. Res. 36, 744.
27. Liu, E., J.I. Goldhaber and J.N. Weiss, 1991, Effects of lysophosphatidylcholine on electrophysiological properties and excitation-contraction coupling in isolated guinea pig ventricular myocytes, J. Clin. Invest. 88, 1819.
28. Man, R.Y.K., T.L. Slater, M.P.J. Pellertier and P.C. Choy, 1983, Alterations of phospholipids in ischemic canine myocardium during acute arrhythmia, Lipids 18, 677.
29. Man, R.Y.K., A.A. Kinnairda, I. Bihler and P.C. Choy, 1990, The association of lysophosphatidylcholine with isolated cardiac myocytes, Lipids 25, 450.
30. McLennan, P.L., M.Y. Abeywardena and J.S. Charnock, 1985, Influence of dietary lipids on arryhthmias and infarction after coronary artery ligation in rats, Can. J. Physiol. Pharmacol. 63, 1411.
31. McLennan, P.L., M.Y. Abeywardena and J.S. Charnock, 1988, Dietary fish oil prevents ventricular fibrillation following coronary artery occlusion and reperfusion, Am. Heart. J. 16, 709.
32. McLennan, P.L., T.M. Bridle, M.Y. Abeywardena and J.S. Charnock, 1992, Dietary lipid modulation of ventricular fibrillation threshod in the marmoset monkey, Am. Heart J. 123, 1555.
33. Nakaya, H., S. Kimura and M. Kanno, 1984a, Suppression of lysophosphatidylcholine-induced abnormal automaticity by verapamil in canine Purkinje fibers, Jpn. J. Pharmacol. 36, 371.
34. Nakaya, H., S. Ozaki, S. Kimura, Y. Gotoh and M. Kanno, 1984b, Effects of verapamil on electrophysiologic disturbances induced by lysophosphatidylcholine in isolated rabbit hearts, Arch. Pharmacodyn. Ther. 270, 88.
35. Pogwizd, S.M., J.R. Onufer, B. Kramer, B.E. Sobel and P.B. Corr, 1986, Induction of delayed afterdepolarizations and triggered activity in canine purkinje fibers by lysophosphoglycerides, Circ. Res. 59, 416.
36. 2+ accumulation in rat cardiac myocytes, Am. J. Physiol. 244 (Heart Circ. Physiol. 13), H32.
37. Shaikh, N.A. and E. Downar, 1981, Time course of changes in porcine myocardial phospholipid levels during ischemia, Circ. Res. 49, 316.
38. Sobel, B.E., P.B. Corr, A.K. Robinson, R.A. Goldstein, F.X. Witkowski and M.S. Klein, 1978, Accumulation of lysophosphoglycerides with arrhythmogenic properties in ischemic myocardium, J. Clin. Invest. 62, 546.
39. Stafford, R.E., T. Fanni and E.A. Dennis, 1989, Interfacial properties and critical micelle concentration of lysophospholipids, Biochemistry 28, 5113.
40. Thandroyen, F.T., A. C. Morris, B. Hagler, B. Ziman, L. Pai, J.T. Willerson and L.M. Buja, 1991, Intracellular calcium transients and arrhythmia in isolated heart cells, Circ. Res. 69, 810.
41. Torasson, M.L., G. Mary, M. Breitenstein, J.A. Knieger and R.E. Biagini, 1989, Comparative toxicity of allylamine and acrolein in cultured myocytes and fibroblasts from neonatal rat heart, Toxicology 56, 107.
42. Undrovinas, A.I., I.A. Fleidervish and J.C. Makielski, 1992, Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine, Circ. Res. 71, 1231.
43. Woodley, S.L., H. Ikenouchi and W. H. Barry, 1991, Lysophosphatidylcholine increases cytosolic calcium in ventricular myocytes by direct action on the sarcolemma, J. Mol. Cell. Cardiol. 23, 671.
44. Xiao, Y.F., J.X. Kang, J.P. Morgan and A. Leaf, 1995, Suppression of voltage-dependent Na + current by eicosapentaenoic acid in neonatal rat cardiac myocytes, Proc. Natl. Acad. Sci. USA. 92, 11000.