Hepcidin, an Acute-Phase Protein and a Marker of Inflammation in Kidney Transplant Recipients With and Without Coronary Artery Disease

Transplantation Proceedings

Volumn 38, Issue 9, 2006, Pages 2895-2898

  Malyszko, J ^a   Malyszko, J S ^a   Pawlak, K ^a   Mysliwiec, M ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; CHOLESTEROL; CREATININE; FERRITIN; HEPCIDIN; INTERLEUKIN 6; IRON; LIPID; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD CELL COUNT; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CREATININE BLOOD LEVEL; DISEASE MARKER; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; INFLAMMATION; IRON BLOOD LEVEL; KIDNEY GRAFT; LABORATORY TEST; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; NEUTROPHIL COUNT; PRIORITY JOURNAL;

ADULT; AGED; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL MARKERS; BLOOD CELL COUNT; BLOOD CHEMICAL ANALYSIS; CORONARY DISEASE; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INFLAMMATION; IRON; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES;

EID: 33750956893     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2006.08.137     Document Type: Article

References (18)

1. Kasiske B.L., Chakkera H.A., and Roel J. Explained and unexplained ischemic heart disease in renal transplant recipients. J Am Soc Nephrol 11 (2000) 1735
2. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 340 (1999) 115
3. Shah S.V., and Alam M.G. Role of iron in atherosclerosis. Am J Kidney Dis 41 suppl1 (2003) S80
4. Park C.H., Valore E.V., Waring A.J., et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276 (2001) 7806
5. Nicolas G., Chauvet C., Viatte L., et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110 (2002) 1037
6. Nemeth E., Rivera S., Gabayan V., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of iron regulatory hormone hepcidin. J Clin Invest 113 (2004) 1271
7. Nemeth E., Valore E.V., Territo M., et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101 (2003) 2461
8. Malyszko J., Malyszko J.S., Hryszko T., et al. Is hepcidin a link between anemia, inflammation and liver function in hemodialyzed patients?. Am J Nephrol 25 (2005) 586
9. Blake G.J., and Ridker P.M. Novel clinical markers of vascular wall inflammation. Clin Res 89 (2001) 763
10. Torti F.M., and Torti S.V. Regulation of ferritin genes and protein. Blood 99 (2002) 3505
11. Dallalio G., Fleury T., and Means R.T. Serum hepcidin in clinical specimens. Br J Haematol 122 (2003) 996
12. Kulaksiz H., Gehrke S.G., Janetzko A., et al. Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 53 (2004) 735
13. Detivaud L., Nemeth E., Boudjema K., et al. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels and hepatic function. Blood 106 (2005) 746
14. Aoki C.A., Rossaro L., Ramsamooj R.R., et al. Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C. J Clin Gastroenterol 39 (2005) 71
15. Bemelmans M.H., Gouma D.J., and Buurman W.A. Influence of nephrectomy on tumor necrosis factor clearance in a murine model. J Immunol 150 (1993) 2007
16. Taes Y.E., Wuyts B., Boelaert J.R., et al. Prohepcidin accumulates in renal insufficiency. Clin Chem Lab Med 42 (2004) 387
17. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102 (2003) 783
18. Weinstein D.A., Roy C.N., Fleming M.D., et al. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100 (2002) 3776