Is hepcidin a link between anemia, inflammation and liver function in hemodialyzed patients?

American Journal of Nephrology

Volumn 25, Issue 6, 2005, Pages 586-590

  Małyszko, Jolanta ^a   Małyszko, Jacek S ^a   Hryszko, Tomasz ^a   Pawlak, Krystyna ^a   Mysliwiec, Michał ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Anemia; Erythropoietin; Hemodialysis; Hepcidin; Iron metabolism

Indexed keywords

ALBUMIN; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CHOLESTEROL; CREATININE; ERYTHROPOIETIN; FERRITIN; HEPCIDIN; IRON; LIPID; TRIACYLGLYCEROL;

ADULT; AGED; ANEMIA; ARTICLE; BLOOD CELL COUNT; CONTROLLED STUDY; CORRELATION ANALYSIS; ERYTHROCYTE COUNT; FEMALE; HEMODIALYSIS; HUMAN; INFLAMMATION; IRON DEFICIENCY; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PRIORITY JOURNAL; THROMBOCYTE COUNT;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA; ANTIMICROBIAL CATIONIC PEPTIDES; CROSS-SECTIONAL STUDIES; ERYTHROPOIETIN; FEMALE; HUMANS; INFLAMMATION; IRON; KIDNEY; KIDNEY FAILURE, CHRONIC; LIVER; MALE; MIDDLE AGED; REGRESSION ANALYSIS;

EID: 29144435254     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000089266     Document Type: Article

References (14)

1. Park CH, Valore EV, Waring AJ, Ganz T: Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-7810.
2. Krause A, Neitz S, Magert HJ, Schyltz A, Forssmann WG, Schulz-Knappe P, Adermann L: LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity. FEBS Lett 2000;480:147-150.
3. Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S: The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-1044.
4. Sunder-Plassmann G, Horl WH: Erythropoietin and iron. Clin Nephrol 1997;47:141-157.
5. Gauldie J, Richards C, Harnish D, Lansdorp P, Baumann H: Interferon β2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci USA 1987;4:7251-7255.
6. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T: Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-2463.
7. Kulaksiz H, Gehrke SG, Janetzko A, Rost D, Bruckner T, Kallinowski B, Stremmel W: Prohepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 2004;53:735-743.
8. Taes YE, Wuyts B, Boelaert JR, De Vriese AS, Delanghe JR: Prohepcidin accumulates in renal insufficiency. Clin Chem Lab Med 2004; 42:387-389.
9. Eschbach JW, Cook JD, Scribner BH, Finch CA: Iron balance in hemodialysis patients. Ann Intern Med 1977;87:710.
10. Roy CN, Andrews NC: Anemia of inflammation: the hepcidin link. Curr Opin Hematol 2005;12:107-111.
11. Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, Loukopoulos D, Camaschella C: Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Gen 2003;33:21-22.
12. Kulaksiz H, Theilig F, Bachmann S, Gehrke SG, Rost D, Janetzko A, Cetin Y, Stremmel W: The iron-regulatory peptide hormone hepcidin: expression and cellular localisation in the mammalian kidney. J Endocrinol 2005;184:361-370.
13. Detivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, Ropert M, Jacquelinet S, Courselaud B, Ganz T, Brissot P, Loreal O: Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels and hepatic function. Blood 2005;106:746-748.
14. Aoki CA, Rossaro L, Ramsamooj RR, Brandhagen D, Burritt MF, Bowlus CL: Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C. J Clin Gastroenterol 2005;39:71-74.