Use of biomonitoring data to evaluate methyl eugenol exposure

Environmental Health Perspectives

Volumn 114, Issue 11, 2006, Pages 1797-1801

  Robison, Steven H ^a   Barr, Dana B ^b  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

Biomonitoring; Exposure assessment; Methyl eugenol; Risk assessment

Indexed keywords

BIOLOGICAL MARKER; METHYLEUGENOL;

ANALYTIC METHOD; ARTICLE; BANANA; BIOLOGICAL MONITORING; BLOOD SAMPLING; ENVIRONMENTAL EXPOSURE; FOOD COMPOSITION; GAS CHROMATOGRAPHY; HERB; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; ISOTOPE LABELING; LIVER CELL CARCINOMA; MASS SPECTROMETRY; NONHUMAN; POPULATION EXPOSURE; POPULATION RISK; PRIORITY JOURNAL; RISK ASSESSMENT; SPICE; TOXICOKINETICS; TOXICOLOGY; TOXIN ANALYSIS; URINARY EXCRETION;

ANIMALS; BIOLOGICAL MARKERS; CARCINOGENS; ENVIRONMENTAL MONITORING; EUGENOL; HUMANS; RISK ASSESSMENT;

ANIMALIA;

EID: 33750851986     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9057     Document Type: Article

References (22)

1. Albertini R, Bird M, Doerrer N, Needham L, Robison S, Sheldon L, et al. 2006. The use of biomonitoring data in exposure and human health risk assessments. Environ Health Perspect 114:1755-1762.
2. Barr DB, Barr JR, Bailey SL, Lapeza CR Jr, Beeson MD, Caudill SP, et al. 2000. Levels of methyl eugenol in a subset of adults in the general U.S. population as determined by high resolution mass spectrometry. Environ Health Perspect 108:323-328.
3. Beroza M, Inscoe MN, Schwartz PH Jr, Keplinger ML, Mastri CW. 1975. Acute toxicity studies with insect attractants. Toxicol Appl Pharmacol 31:421-429.
4. Burkey JL, Sauer JM, McQueen CA, Sipes IG. 2000. Cytotoxicity and genotoxicity of methyleugenol and related congeners - a mechanism of activation for methyleugenol. Mutat Res 453:25-33.
5. CDC. 2004. Third National Report on Human Exposure to Environmental Chemicals. Atlanta:Centers for Disease Control and Prevention. Available: http://www.cdc.gov/exposurereport/pdf/ third_report_chemicals.pdf [accessed 11 August 2004].
6. Chan VS, Caldwell J. 1992. Comparative induction of unscheduled DNA synthesis in cultured rat hepatocytes by allylbenzenes and their 1′-hydroxy metabolites. Food Chem Toxicol 30: 831-836.
7. De Simon BF, Cadahia E, Jalocha J. 2003. Volatile compounds in a Spanish red wine aged in barrels made of Spanish, French, and American oak wood. J Agric Food Chem 51:7671-7678.
8. Di Cesare LF, Forni E, Viscardi D, Nani RC. 2003. Changes in the chemical composition of basil caused by different drying procedures. J Agric Food Chem 51:3575-3581.
9. European Centre for Ecotoxicology and Toxicology of Chemicals. 2005. Guidance for the Interpretation of Biomonitoring Data. Doc no. 44. Appendix B10. Brussels:European Centre for Ecotoxicology and Toxicology of Chemicals, 43-45. Available: http://www.ecetoc.org/content/ Default.asp?PageID=21 [accessed 25 January 2006].
10. Gardner I, Wakazono H, Bergin P, de Waziers I, Beaune P, Kenna JG, et al. 1997. Cytochrome P450 mediated bioactivation of methyleugenol to 1′-hydroxymethyleugenol in Fischer 344 rat and human liver microsomes. Carcinogenesis 18:1775-1783.
11. Howes AJ, Chan VS, Caldwell J. 1990. Structure-specificity of the genotoxicity of some naturally occurring alkenylbenzenes determined by the unscheduled DNA synthesis assay in rat hepatocytes. Food Chem Toxicol 28:537-542.
12. Jeurissen SM, Bogaards JJ, Boersma MG, ter Horst JP, Awad HM, Fiamegos YC, et al. 2006. Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol. Chem Res Toxicol 19:111-116.
13. Jordan MJ, Tandon K, Shaw PE, Goodner KL. 2001. Aromatic profile of aqueous banana essence and banana fruit by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-olfactometry (GC-O). J Agric Food Chem 49: 4813-4817.
14. MacGregor JT, Layton LL, Buttery RG. 1974. California bay oil. II. Biological effects of constituents. J Agric Food Chem 22:777-780.
15. Miele M, Dondero R, Ciarallo G, Mazzei M. 2001. Methyleugenol in Ocimum basilicum L. Cv. genovese gigante. J Agric Food Chem 49:517-521.
16. 1 Mice (Gavage Studies). Technical Report 491. Research Triangle Park, NC:National Toxicology Program, National Institute of Environmental Health Sciences.
17. Rietjens IM, Boersma MG, van der WH, Jeurissen SM, Schutte ME, Alink GM. 2005. Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk. Mutat Res 574:124-138.
18. Schecter A, Lucier GW, Cunningham ML, Abdo KM, Blumenthal G, Silver AG, et al. 2004. Human consumption of methyleugenol and its elimination from serum. Environ Health Perspect 112:678-680.
19. Smith R, Adams T, Doull J, Feron V, Goodman J, Marnett L, et al. 2002. Safety assessment of allylalkoxybenzene derivatives used in flavoring substances - methyl eugenol and estragole. Food Chem Toxicol 40:851-870.
20. Vargas RI, Stark JD, Kido MH, Ketter HM, Whitehand LC. 2000. Methyl eugenol and cue-lure traps for suppression of male oriental fruit flies and melon flies (Diptera: Tephritidae) in Hawaii: effects of lure mixtures and weathering. J Econ Entomol 93:81-87.
21. Waddell WJ. 2002. Thresholds of carcinogenicity of flavors. Toxicol Sci 68:275-279.
22. Waddell WJ, Crooks NH, Carmichael PL. 2004. Correlation of tumors with DNA adducts from methyl eugenol and tamoxifen in rats. Toxicol Sci 79:38-40.